Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Stem Cell Research & Therapy, Journal Year: 2019, Volume and Issue: 10(1)

Published: March 29, 2019

Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, various cells. Any failure in these phases may lead wounds to become chronic have abnormal scar formation. Chronic affect patients' quality of life, since they require repetitive treatments incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for treatment. Stem-cell-based strategies proposed treat wounds. They shown potential improving the rate regenerating skin. However, there are many challenges using stem cells skin regeneration. In this review, we present some sets data published embryonic cells, induced pluripotent adult Additionally, will discuss different angles whereby can contribute their unique features show current drawbacks.

Language: Английский

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Athletes and Supplements: Prevalence and Perspectives

International Journal of Sport Nutrition and Exercise Metabolism, Journal Year: 2018, Volume and Issue: 28(2), P. 126 - 138

Published: March 1, 2018

In elite sport, where opponents are evenly matched, small factors can determine the outcome of sporting contests. Not all athletes know value making wise nutrition choices, but anything that might give a competitive edge, including dietary supplements, seem attractive. Between 40% and 100% typically use depending on type level competition, definition supplements. However, unless athlete has nutrient deficiency, supplementation may not improve performance have detrimental effect both health. Dietary supplements classified as subcategory food, so manufacturers required to provide evidence product safety efficacy, nor obtain approval from regulatory bodies before marketing This creates potential for health risks, serious adverse effects been reported some Athletes who compete in sports under an anti-doping code must also realize supplement exposes them risk ingesting banned substances or precursors prohibited substances. Government systems regulations do include specific laboratory testing according WADA list, separate framework evaluate their provoking failed doping test is needed. high-performance culture typical regardless possible risks. A discussion around medical, physiological, cultural, ethical questions be warranted ensure information needed make informed choice.

Language: Английский

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Preparation and Incorporation of Functional Ingredients in Edible Films and Coatings

Food and Bioprocess Technology, Journal Year: 2020, Volume and Issue: 14(2), P. 209 - 231

Published: Sept. 18, 2020

Language: Английский

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The ovarian stroma as a new frontier

Reproduction, Journal Year: 2020, Volume and Issue: 160(3), P. R25 - R39

Published: June 23, 2020

Historically, research in ovarian biology has focused on folliculogenesis, but recently the stroma become an exciting new frontier for research, holding critical keys to understanding complex dynamics. Ovarian follicles, which are functional units of ovary, comprise parenchyma, while thus refers inverse or components ovary that not follicles. The includes more general such as immune cells, blood vessels, nerves, and lymphatic well ovary-specific including surface epithelium, tunica albuginea, intraovarian rete ovarii, hilar stem a majority incompletely characterized stromal cells fibroblast-like, spindle-shaped, interstitial cells. also extracellular matrix components. This review combines foundational emerging scholarship regarding structures roles different normal physiology. is followed by discussion key areas further stroma, elucidating theca cell origins, hormone production responsiveness, investigating pathological conditions polycystic syndrome (PCOS), developing artificial technology, using technological advances delineate multiple types.

Language: Английский

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The gut microbiome: a core regulator of metabolism

Journal of Endocrinology, Journal Year: 2022, Volume and Issue: 256(3)

Published: Dec. 2, 2022

The human body is inhabited by numerous bacteria, fungi, and viruses, each part has a unique microbial community structure. gastrointestinal tract harbors approximately 100 trillion strains comprising more than 1000 bacterial species that maintain symbiotic relationships with the host. gut microbiota consists mainly of phyla Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria. Of these, Firmicutes Bacteroidetes constitute 70-90% total abundance. Gut utilize nutrients ingested host, interact other species, help healthy homeostasis in In recent years, it become increasingly clear breakdown structure its functions, known as dysbiosis, associated development allergies, autoimmune diseases, cancers, arteriosclerosis, among others. Metabolic such obesity diabetes, also have causal relationship dysbiosis. present review provides brief overview general roles their metabolic disorders.

Language: Английский

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Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(22), P. 5890 - 5910

Published: Jan. 12, 2022

Inflammatory bowel disease (IBD) is a chronic, multifactorial and inflammatory occurring in the colon tract. Bioactive polysaccharides from natural resources have attracted extensive attention due to their safety, accessibility good bioactivities. In recent years, variety of bioactive been proven possess anti-inflammatory effects on treating acute colitis. The objective this review was give an up-to-date mechanisms colitis concerning clinical symptoms amelioration, tissue repairment, anti-oxidative stress alleviation, anti-inflammation, immune regulation, gut microbiota modulation were comprehensively summarized. addition, inducible murine models for assessing also concluded. This will offer comprehensive understanding colitis, render theoretical basis development application drug functional food.

Language: Английский

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Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

Briefings in Bioinformatics, Journal Year: 2022, Volume and Issue: 23(6)

Published: Sept. 12, 2022

Abstract MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex diseases such as cancers, and thus serve potential diagnostic markers therapeutic targets. The prerequisite for designing effective miRNA therapies is accurate discovery miRNA-disease associations (MDAs), which has attracted substantial research interests during last 15 years, reflected by more than 55 000 related entries available on PubMed. Abundant experimental data gathered from wealth literature could effectively support development computational models predicting novel associations. In 2017, Chen et al. published first-ever comprehensive review MDA prediction, presenting various relevant databases, 20 representative models, suggestions building powerful ones. current review, continuation previous study, we revisit biogenesis, detection techniques functions; summarize recent findings to common miRNA-associated diseases; introduce updates miRNA-relevant databases database releases since present mainstream webservers new webserver 2017 finally elaborate how fusion diverse sources contributed prediction.

Language: Английский

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Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen

Journal of Endocrinology, Journal Year: 2023, Volume and Issue: 259(1)

Published: July 31, 2023

Estrogens (estradiol, estriol, and estrone) are important hormones that directly indirectly regulate the metabolism function of bone skeletal muscle via estrogen receptors. Menopause causes a dramatic reduction in concentration body. This contributes to decline function, thereby resulting osteoporosis sarcopenia. Menopausal women often experience wasting, clinicians recognize as playing an role these conditions, particularly women. Bone closely related endocrine tissues synthesize produce various cytokines. These bone- muscle-derived cytokines, including interleukin-6, irisin, β-aminoisobutyric acid, osteocalcin, fibroblast growth factor-23, sclerostin, both local distant tissues, they mediate crosstalk between muscle. review examines metabolic effects on describes cytokine-mediated bone–muscle conditions deficiency.

Language: Английский

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Hormonal changes in PCOS

Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 261(1)

Published: Jan. 29, 2024

Polycystic ovary syndrome (PCOS) is a common endocrinopathy occurring in reproductive-age women. Hyperandrogenism, polycystic ovaries, chronic anovulation, and metabolic aberrations are the features PCOS. Hormonal changes causing pathological symptoms women with The various hormone alterations PCOS have been demonstrated. Hormones, such as insulin, growth hormones (GH), ghrelin, LEAP-2, gonadotropin-releasing (GnRH), luteinizing hormone/follicle-stimulating (LH/FSH) ratio, androgens, estrogens, all abnormal These related to disorders, diabetes insulin resistance, overweight obesity, infertility, disturbed menstrual cycle patients. of these hormones, increased reduced GH, leptin result an prevalence obesity A LEAP-2 levels, high LH basal, LH/FSH low estrogen demonstrated linked infertility. This narrative review aims clarify profiles, LH, FSH, estrogen, progesterone, asprosin, subfatin, PCOS, which may reveal novel targets for better diagnosis treatment

Language: Английский

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iAMPCN: a deep-learning approach for identifying antimicrobial peptides and their functional activities

Briefings in Bioinformatics, Journal Year: 2023, Volume and Issue: 24(4)

Published: June 27, 2023

Antimicrobial peptides (AMPs) are short that play crucial roles in diverse biological processes and have various functional activities against target organisms. Due to the abuse of chemical antibiotics microbial pathogens' increasing resistance antibiotics, AMPs potential be alternatives antibiotics. As such, identification has become a widely discussed topic. A variety computational approaches been developed identify based on machine learning algorithms. However, most them not capable predicting AMPs, those predictors can specify only focus few them. In this study, we first surveyed 10 their terms features they employed algorithms utilized. Then, constructed comprehensive AMP datasets proposed new deep learning-based framework, iAMPCN (identification CNNs), related 22 activities. Our experiments demonstrate significantly improved prediction performance corresponding four types sequence features. Benchmarking independent test showed outperformed number state-of-the-art for Furthermore, analyzed amino acid preferences different evaluated model varying redundancy thresholds. To facilitate community-wide types, made source codes publicly available at https://github.com/joy50706/iAMPCN/tree/master. We anticipate explored as valuable tool identifying with specific further experimental validation.

Language: Английский

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