Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(7), P. 2364 - 2364

Published: March 29, 2020

Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, anti-angiogenic purposes. We conducted a literature review to summarize studies investigating relationship between curcumin colorectal cancer (CRC). In vitro studies, performed on human colon lines, showed that inhibited cellular growth cycle arrest at G2/M G1 phases, well stimulated apoptosis by interacting with multiple molecular targets. vivo have in inflammatory genetic CRC animal models chemopreventive effect. To improve bioavailability, associated small particles increase absorption when orally administered excellent results both inflammation carcinogenesis. used, moreover, component of dietetic formulations chemoprevention. These combinations anticarcinogenetic properties inflammation-related CRC. A synergic effect was suggested using individual constituent dosage, which lower than experimentally used “in vivo” single components. conclusion, falls within category plant origin substances able prevent animals. This property offers promising expectations humans.

Language: Английский

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Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1532 - 1532

Published: Jan. 28, 2022

Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, oxaliplatin, have been widely used to treat a multitude of human cancers. However, considerable proportion patients often relapse due drug resistance and/or toxicity multiple organs including the liver, kidneys, gastrointestinal tract, cardiovascular, hematologic, nervous systems. In this study, we sought provide comprehensive review current state science highlighting use cisplatin in cancer therapy, with special emphasis on its molecular mechanisms action, treatment modalities combination therapy natural products. Hence, searched literature using various scientific databases., MEDLINE, PubMed, Google Scholar, relevant sources, collect publications cisplatin, products, uses treatment, modes therapeutic strategies. Our search results revealed that new strategic approaches for evaluated some degree success. Scientific evidence from both vitro vivo studies demonstrates many medicinal plants contain bioactive compounds are promising candidates diseases, therefore represent an excellent source discovery. preclinical studies, it has demonstrated products not only enhance activity but also attenuate chemotherapy-induced toxicity. Many experimental reported exert their action by triggering apoptosis through modulation mitogen-activated protein kinase (MAPK) p53 signal transduction pathways enhancement chemosensitivity. Furthermore, protect against cisplatin-induced organ modulating several gene transcription factors inducing cell death necrosis. addition, formulations polymeric, lipid, inorganic, carbon-based nano-drug delivery systems found delay release, prolong half-life, reduce systemic while formulations, nanocapsules, nanogels, hydrogels, penetration, target cells, inhibit tumor progression.

Language: Английский

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Anticancer Properties of Curcumin Against Colorectal Cancer: A Review

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: April 22, 2022

Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well world's second largest cause mortality. Despite existing preventative, diagnostic, treatment methods, such chemotherapy, number instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, curcumin, have shown significant anti-colorectal characteristics among that can used treat These chemicals are phenolic compounds belong curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro vivo via variety mechanisms, including suppression intrinsic extrinsic apoptotic signaling pathways, stoppage cycle, activation autophagy. also has anti-angiogenesis properties. Thus, this review aimed at emphasizing biological effect mode action curcumin on Furthermore, critical role these substances chemoprevention was emphasized.

Language: Английский

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Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success

Advances in Cancer Biology - Metastasis, Journal Year: 2024, Volume and Issue: 10, P. 100114 - 100114

Published: Jan. 17, 2024

A significant obstacle to treating cancer is multidrug resistance (MDR), which the capacity of cancerous cells develop both traditional and cutting-edge chemotherapeutic treatments. Following initial discovery that cellular pumps reliant on ATP were root chemotherapy resistance, more research has revealed involvement additional mechanisms, including increased drug metabolism, reduced entry, compromised apoptotic pathways. Numerous projects have focused MDR, innumerable been conducted better understand MDR methods mitigate its consequences. Multidrug (MDR) a key challenge in cancer. 90% cancer-related fatalities are brought by tumor metastasis recurrence, possible with MDR. Drug influenced diverse internal extrinsic variables, genetic epigenetic changes, efflux systems, DNA repair apoptosis, autophagy. In this review paper, we list potential hazards associated therapy general, primarily developing theory for colorectal particular. We discussed unique instance malignancies generally 5-fluorouracil, curcumin, lipids as viable options condition. The use nanotechnology (mainly nanoparticles) facilitated vitro well vivo efficacy during preclinical phases, summarized below, allowing thorough investigation cancers pancreatic carcinomas their translation following clinical trials.

Language: Английский

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Inflammation in cancer: therapeutic opportunities from new insights

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 24, 2025

As one part of the innate immune response to external stimuli, chronic inflammation increases risk various cancers, and tumor-promoting is considered enabling characteristics cancer development. Recently, there has been growing evidence on role anti-inflammation therapy in prevention treatment. And researchers have already achieved several noteworthy outcomes. In review, we explored underlying mechanisms by which affects occurrence development cancer. The pro- or anti-tumor effects these inflammatory factors such as interleukin, interferon, chemokine, inflammasome, extracellular matrix are discussed. Since FDA-approved drugs like aspirin show obvious effects, unique advantages due their relatively fewer side with long-term use compared chemotherapy drugs. make them promising candidates for chemoprevention. Overall, this review discusses molecules carcinogenesis new molecules-directed therapeutic opportunities, ranging from cytokine inhibitors/agonists, inflammasome inhibitors, some inhibitors that expected be applied clinical practice, well recent discoveries effect non-steroidal anti-inflammatory steroidal disadvantages application chemoprevention also

Language: Английский

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Mechanistic Understanding of Curcumin’s Therapeutic Effects in Lung Cancer

Nutrients, Journal Year: 2019, Volume and Issue: 11(12), P. 2989 - 2989

Published: Dec. 6, 2019

Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite significant advances in diagnostic and therapeutic approaches, lung prognoses survival rates remain poor due to late diagnosis, drug resistance, adverse effects. Therefore, new intervention therapies, such as use of natural compounds decreased toxicities, have been considered therapy. Curcumin, occurring polyphenol derived from turmeric (Curcuma longa) has studied extensively recent years for its It shown that curcumin demonstrates anti-cancer effects through various mechanisms, including inhibition cell proliferation, invasion, metastasis, induction apoptosis, epigenetic alterations, regulation microRNA expression. Several vitro vivo studies these mechanisms are modulated by multiple molecular targets STAT3, EGFR, FOXO3a, TGF-β, eIF2α, COX-2, Bcl-2, PI3KAkt/mTOR, ROS, Fas/FasL, Cdc42, E-cadherin, MMPs, adiponectin. In addition, limitations, strategies overcome bioavailability, potential side well clinical trials were also reviewed.

Language: Английский

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Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

Biomolecules, Journal Year: 2020, Volume and Issue: 10(1), P. 105 - 105

Published: Jan. 8, 2020

Gastrointestinal (GI) cancer is a prevailing global health disease with high incidence rate which varies by region. It huge economic burden on care providers. GI affects different organs in the body such as gastric organs, colon, esophagus, intestine, and pancreas. Internal external factors like smoking, obesity, urbanization, genetic mutations, prevalence of Helicobacter pylori Hepatitis B C viral infections could increase risk cancer. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found fruits, grains, vegetables. Consumption phytochemicals may protect against chronic diseases cardiovascular disease, neurodegenerative Multiple studies have assessed chemoprotective effect selected cancer, offering support to their potential towards reducing pathogenesis disease. The aim this review was summarize current knowledge addressing anti-cancerous effects dietary molecular activities mechanisms, i.e., nuclear factor kappa-light-chain-enhancer activated cells (NF-κB), detoxification enzymes, adenosine monophosphate protein kinase (AMPK), wingless-related integration site/β-catenin (wingless-related site (Wnt) β-catenin, cell apoptosis, phosphoinositide 3-kinases (PI3K)/ AKT/ mammalian target rapamycin (mTOR), mitogen-activated (MAPK). In were classified into four main categories: (i) carotenoids, including lutein, lycopene, β-carotene; (ii) proanthocyanidins, quercetin ellagic acid; (iii) organosulfur compounds, allicin, allyl propyl disulphide, asparagusic acid, sulforaphane; (iv) other pectin, curcumins, p-coumaric acid ferulic acid. Overall, improve prognosis through downregulation β-catenin phosphorylation, therefore enhancing upregulation AMPK pathway, supports cellular homeostasis. Nevertheless, more needed provide better understanding mechanism treatment using possible side associated approach.

Language: Английский

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Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

Molecules, Journal Year: 2020, Volume and Issue: 25(22), P. 5319 - 5319

Published: Nov. 14, 2020

Cancer is one of the main causes death globally and considered as a major challenge for public health system. The high toxicity lack selectivity conventional anticancer therapies make search alternative treatments priority. In this review, we describe plant-derived natural products used agents. Natural sources, extraction methods, mechanisms, clinical studies, pharmaceutical formulation are discussed in review. Studies covered by review should provide solid foundation researchers physicians to enhance basic research on developing therapies.

Language: Английский

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A functionalized graphene oxide with improved cytocompatibility for stimuli-responsive co-delivery of curcumin and doxorubicin in cancer treatment

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Feb. 4, 2022

Abstract Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts attention many researchers treatment cancers. Graphene oxide (GO) is one novel delivery systems which used broadly owing to its unique features. In this survey, doxorubicin (DOX) was accompanied by natural medicine, curcumin (CUR), diminish side effects and enhance efficiency. Cytotoxicity assay human gastric cancer (AGS), prostate (PC3), ovarian (A2780), evaluated. Also, uptake DOX CUR into cells, assessed using a fluorescence microscope. Moreover, real-time PCR applied for evaluation expression RB1 CDK2 genes, were involved cell cycle. both separate simultaneous forms, loaded with high efficiency release behavior drugs pH-sensitive. The higher rate attained at pH 5.5 42 °C (80.23%) (13.06), respectively. intensity free form drugs, than form. same concentration, more toxic all lines. showed impact on genes. Co-delivery mentioned lines, effective due lower toxicity normal cells.

Language: Английский

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Plants as a Source of Anticancer Agents: From Bench to Bedside

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4818 - 4818

Published: July 27, 2022

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack selectivity and serious side effects. hallmarks biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple a promising strategy to treat cancer. The diversity in chemical structure relatively low toxicity make plant-derived natural products source for development new more effective that have capacity target In this review, we discussed activities ten extracted from plants. majority these inhibit targeting hallmarks, many chemicals reached clinical applications. Studies review provide solid ground researchers physicians design combination using products.

Language: Английский

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