Health Promoting Properties of Bee Royal Jelly: Food of the Queens

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 543 - 543

Published: Feb. 7, 2021

Royal jelly (RJ) demand is growing every year and so the market for functional foods in general. RJ formed by different substances, mainly carbohydrates, proteins, lipids, but also vitamins, minerals, phenolic or volatile compounds lower proportion. Major royal proteins (MRJP) are, together with 10-hydroxy-2-decenoic acid (10-HDA), key substances of due to their biological properties. In particular, 10-HDA a unique substance this product. has been historically employed as health enhancer still very relevant China traditional medicine apitherapy. Nowadays, it consumed food found supplements other formulations its health-beneficial Within these properites, anti-lipidemic, antioxidant, antiproliferative, antimicrobial, neuroprotective, anti-inflammatory, immunomodulatory, antiaging, estrogenic activities have reported specific components. This manuscript aimed at reviewing current knowledge on components, assessment terms authenticity, activities, related applications.

Language: Английский

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Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

Antibiotics, Journal Year: 2021, Volume and Issue: 10(7), P. 822 - 822

Published: July 6, 2021

Bee products have long been used in traditional healing practices to treat many types of disorders, including cancer and microbial-related diseases. Indeed, several chemical compounds found bee demonstrated display anticancer, antibacterial, antiviral, antiparasitic properties. With the improvement research tools view recent advances related products, this review aims provide broad yet detailed insight into pharmaceutical prospects such as honey, propolis, pollen, royal jelly, bread, beeswax, venom, domain infectious disease management. Available literature confirms efficacy these alleviation progression, inhibition bacterial viral proliferation, mitigation parasitic-related symptoms. potentials, bioactive components isolated from can be an alternative approach long-run effort improve humans’ health at a personal community level.

Language: Английский

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The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

Biology, Journal Year: 2022, Volume and Issue: 11(2), P. 233 - 233

Published: Feb. 1, 2022

The concept of ecosystem services is widely understood as the and benefits thatecosystems provide to humans, they have been categorised into provisioning, regulating, supporting, cultural services. This article aims an updated overview that honey bee Apis mellifera provides humans well ecosystems. We revised role bees pollinators in natural ecosystems preserve restore local biodiversity wild plants; agro-ecosystems, this species used enhance crop yield quality, meeting increasing food demand. Beekeeping activity not only with high-quality but also substances raw materials pharmaceuticals, polluted areas, convey valuable information on environmental presence pollutants their impact human health. Finally, symbolic tradition, mysticism, values habitats are presented. Overall, we suggest value most important played by insect species, it may help revitalise strengthen intimate reciprocal relationship between world, avoiding inaccuracy considering mere providers humans.

Language: Английский

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Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 8

Published: Jan. 3, 2022

Graphical Abstract The anti-inflammatory and immunomodulatory possible mechanisms of action bee products suggested by preclinical clinical studies.

Language: Английский

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Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1510 - 1510

Published: Feb. 3, 2023

Royal jelly (RJ) has been one of the most widely used natural products in alternative medicine for centuries. Being produced by both hypopharyngeal and mandibular glands, RJ exhibits an extraordinary complexity terms its composition, including proteins, lipids, carbohydrates, polyphenols, vitamins, hormones. Due to heterogeneous structure, displays various functional roles honeybees, being involved nutrition, learning, memory, social behavior. Furthermore, a wide range studies reported therapeutic properties, anticancer, anti-inflammatory, antioxidant activities, name few. In this direction, there is health-related problems which medical area specialists researchers are continuously trying find cure, such as cancer, atherosclerosis, or infertility. For mentioned diseases more, it proven that key player finding valuable treatment. review, great impact agent highlighted, with focus on activities. Moreover, we link apitherapeutic potential discussing composition. Herein, discuss novel present latest research work.

Language: Английский

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Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

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Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Foods, Journal Year: 2020, Volume and Issue: 9(10), P. 1362 - 1362

Published: Sept. 25, 2020

The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in up to 50% older adults is increasing worldwide due the expansion aging populations. It now striking young midlife as well because sedentary lifestyle increased intake unhealthy food (e.g., western diet). lockdown measures economic turndown associated with current outbreak Coronavirus Disease 2019 (COVID-19) are likely increase prevalence sarcopenia by promoting sedentarism patterns eating. Sarcopenia has multiple detrimental effects including falls, hospitalization, disability, institutionalization. Although a few pharmacological agents bimagrumab, sarconeos, exercise mimetics) being explored different stages trials, not single drug been approved for treatment. Hence, research focused on testing effect nutraceuticals, such bee products, safe treatments prevent and/or treat sarcopenia. Royal jelly, propolis, pollen common products that rich highly potent antioxidants flavonoids, phenols, amino acids. These order, stimulate larval development into queen bees, promote defenses hive against microbial environmental threats, royal jelly production nurse bees. Thanks their versatile activities anti-aging, anti-inflammatory, anticarcinogenic, antimicrobial, etc.), these have used chronic conditions predispose wasting hypertension, diabetes mellitus, cardiovascular disorder, cancer, name few. They were also some evolving studies laboratory animals and, limited degree, humans. However, collective understanding mechanism action well-developed. Therefore, this review examines literature possible pollen, propolis aged experimental models, cell cultures, Collectively, data from reviewed denote varying levels positive mass, strength, function. underlying mechanisms include amelioration inflammation oxidative damages, promotion metabolic regulation, enhancement satellite stem responsiveness, improvement muscular blood supply, inhibition catabolic genes, peripheral neuronal regeneration. This offers suggestions other be provides guidance future trials investigating among people

Language: Английский

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Active components and biological functions of royal jelly

Journal of Functional Foods, Journal Year: 2021, Volume and Issue: 82, P. 104514 - 104514

Published: May 11, 2021

Royal jelly (RJ) is a kind of bee product widely used in cosmetics, medicine and other fields. Not only can RJ regulate the physiological function population, but also play specific biological role many diseases. This paper overviews main active ingredients functional food RJ, including major royal protein, fatty acids, phenols, flavonoids, etc, summarizes maintenance human health, such as regulation immunity, lifespan, memory, digestive system, blood glucose, obesity, antibacterial anti-cancer effect, among which memory be treatment Alzheimer's disease. These findings will benefit for comprehensive understanding use hence making it more effective maintaining health.

Language: Английский

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Alternative therapies for dry eye disease

Current Opinion in Ophthalmology, Journal Year: 2021, Volume and Issue: 32(4), P. 348 - 361

Published: May 18, 2021

Purpose of review Dry eye disease (DED) is a multifactorial affecting approximately 5–50% individuals in various populations. Contributors to DED include, but are not limited to, lacrimal gland hypofunction, meibomian dysfunction (MGD), ocular surface inflammation, and corneal nerve dysfunction. Current treatments target some facets the disease, such as all experience adequate symptom relief. As such, this focuses on alternative adjunct approaches that being explored underlying contributors DED. Recent findings Neuromodulation, stem cell treatments, oral royal jelly have been studied with promising results. In MGD, devices provide eyelid warming or intense pulsed light therapy may reduce symptoms signs, topical Manuka honey. For those naturally derived anti-inflammatory agents be helpful, compound trehalose farthest along process investigation. Nerve growth factor, blood-derived products, neurotization, lesser degree, fatty acids neurotrophic keratitis (i.e. hyposensitivity). Various adjuvant therapies investigated neuropathic pain hypersensitivity) including blocks, neurostimulation, botulinum toxin, acupuncture, although study numbers design generally weaker than for other sub-types. Summary Several alternatives aspects disease. many, more robust studies required assess their sustainability applicability.

Language: Английский

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Structural characterization and antibacterial activity of silver nanoparticles synthesized using a low-molecular-weight Royal Jelly extract

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Aug. 18, 2022

Abstract In recent years silver nanoparticles (Ag NPs) gained increased and widespread applications in various fields of industry, technology, medicine. This study describes the green synthesis applying a low-molecular-weight fraction (LMF) Royal Jelly, nanoparticle characterization, particularly their antibacterial activity. The optical properties NPs, characterized by UV–Vis absorption spectroscopy, showed peak at ~ 430 nm. hydrodynamic radius concentration were determined complementary dynamic light scattering (DLS) tracking analysis (NTA). particle morphology was investigated using transmission electron microscopy (TEM), crystallinity confirmed X-ray diffraction (XRD). activities evaluated utilizing Gram-negative Gram-positive bacteria colony counting assays. growth inhibition curve method applied to obtain information about corresponding minimum inhibitory concentrations (MIC) bactericidal (MBC) required. Obtained results that (i) sizes Ag NPs are increasing within increase ion precursor concentration, (ii) DLS, agreement with NTA, most particles have dimensions range 50–100 nm; (iii) E. coli more susceptible all NP samples compared B. subtilis .

Language: Английский

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