Frontiers in Aging Neuroscience,
Journal Year:
2022,
Volume and Issue:
14
Published: Oct. 17, 2022
Alzheimer’s
disease
(AD)
is
the
most
prevalent
neurodegenerative
disease,
affecting
more
than
55
million
individuals
worldwide
in
2021.
In
addition
to
“amyloid
hypothesis,”
an
increasing
number
of
studies
have
demonstrated
that
phosphorylated
tau
plays
important
role
AD
pathogenesis.
Both
soluble
oligomers
and
insoluble
aggregates
brain
can
induce
structural
functional
neuronal
damage
through
multiple
pathways,
eventually
leading
memory
deficits
neurodegeneration.
Autophagy
cellular
response
various
stress
stimuli
generally
be
categorized
into
non-selective
selective
autophagy.
Recent
indicated
both
types
autophagy
are
involved
pathology.
Among
several
subtypes
autophagy,
mitophagy,
which
mediates
removal
mitochondria,
has
attracted
attention
because
dysfunctional
mitochondria
been
suggested
contribute
tauopathies.
this
review,
we
summarize
latest
findings
on
bidirectional
association
between
abnormal
proteins
defective
as
well
might
constitute
a
vicious
cycle
induction
Neuroinflammation,
another
feature
pathogenesis
progression
AD,
shown
crosstalk
with
mitophagy.
Additionally,
comprehensively
discuss
relationship
neuroinflammation,
By
elucidating
underlying
molecular
mechanisms
governing
these
pathologies,
highlight
novel
therapeutic
strategies
targeting
mitophagy
such
those
using
rapamycin,
urolithin,
spermidine,
curcumin,
nicotinamide,
actinonin,
for
prevention
treatment
AD.
Pharmaceuticals,
Journal Year:
2020,
Volume and Issue:
13(7), P. 153 - 153
Published: July 16, 2020
Curcumin,
a
principal
bioactive
substance
of
turmeric
(Curcuma
longa
L.),
is
reported
as
strong
antioxidant,
anti-inflammatory,
antibacterial,
antifungal,
and
antiviral
agent.
However,
its
antimicrobial
properties
require
further
detailed
investigations
into
clinical
multidrug-resistant
(MDR)
isolates.
In
this
work,
we
tested
curcumin's
efficacy
against
over
100
strains
pathogens
belonging
to
19
species.
This
activity
was
determined
by
the
broth
microdilution
method
calculating
minimum
inhibitory
concentration
(MIC).
Our
findings
confirmed
much
greater
sensitivity
Gram-positive
than
Gram-negative
bacteria.
study
exhibited
significantly
larger
variation
in
curcumin
previous
works
suggested
that
numerous
widespread
have
poor
curcumin.
Similarly,
MICs
MDR
types
Staphylococcus
aureus,
S.
haemolyticus,
Escherichia
coli,
Proteus
mirabilis
were
high
(≥2000
µg/mL).
effective
some
species
strains:
Streptococcus
pyogenes
(median
MIC
=
31.25
µg/mL),
methicillin-sensitive
aureus
(250
Acinetobacter
lwoffii
individual
Enterococcus
faecalis
Pseudomonas
aeruginosa
(62.5
The
not
associated
with
affiliation
genus,
it
could
differ
lot
(e.g.,
pyogenes,
agalactiae
A.
lwoffii,
baumannii).
Hence,
can
be
considered
promising
antibacterial
agent,
but
very
selective
activity.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1117 - 1117
Published: May 24, 2022
Alzheimer’s
disease
(AD)
is
the
most
common
cause
of
dementia.
The
pathophysiology
this
characterized
by
accumulation
amyloid-β,
leading
to
formation
senile
plaques,
and
intracellular
presence
neurofibrillary
tangles
based
on
hyperphosphorylated
tau
protein.
In
therapeutic
approach
AD,
we
can
identify
three
important
fronts:
approved
drugs
currently
available
for
treatment
disease,
which
include
aducanumab,
donepezil,
galantamine,
rivastigmine,
memantine,
a
combination
memantine
donepezil;
therapies
under
investigation
that
work
mainly
Aβ
pathology
pathology,
γ-secretase
inhibitors,
β-secretase
α-secretase
modulators,
aggregation
metal
interfering
drugs,
enhance
clearance,
inhibitors
protein
hyperphosphorylation,
promote
clearance
tau,
finally,
other
alternative
designed
improve
lifestyle,
thus
contributing
prevention
disease.
Therefore,
aim
review
was
analyze
describe
current
treatments
possible
future
alternatives
in
AD.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(23), P. 7109 - 7109
Published: Nov. 24, 2021
Curcumin
is
the
primary
polyphenol
in
turmeric's
curcuminoid
class.
It
has
a
wide
range
of
therapeutic
applications,
such
as
anti-inflammatory,
antioxidant,
antidiabetic,
hepatoprotective,
antibacterial,
and
anticancer
effects
against
various
cancers,
but
poor
solubility
low
bioavailability.
Objective:
To
improve
curcumin's
bioavailability,
plasma
concentration,
cellular
permeability
processes.
The
nanocurcumin
approach
over
curcumin
been
proven
appropriate
for
encapsulating
or
loading
(nanocurcumin)
to
increase
its
potential.
Conclusion:
Though
incorporating
into
form
may
be
viable
method
overcoming
intrinsic
limitations,
there
are
reasonable
concerns
regarding
toxicological
safety
once
it
enters
biological
pathways.
This
review
article
mainly
highlights
benefits
curcumin.
Seminars in Immunology,
Journal Year:
2023,
Volume and Issue:
69, P. 101802 - 101802
Published: July 7, 2023
The
multifaceted
microbiota
characterizing
our
gut
plays
a
crucial
role
in
maintaining
immune,
metabolic
and
tissue
homeostasis
of
the
intestine
as
well
distal
organs,
including
central
nervous
system.
Microbial
dysbiosis
is
reported
several
inflammatory
intestinal
diseases
characterized
by
impairment
epithelial
vascular
barriers,
defined
leaky
gut,
it
potential
danger
condition
associated
with
development
metabolic,
neurodegenerative
diseases.
Recently,
we
pointed
out
strict
connection
between
brain
via
novel
axis.
Here
want
to
deepen
knowledge
on
gut-brain
axis,
particular
emphasis
microbial
dysbiosis,
cerebral
firm
association
axis
will
be
summarized
context
protection,
amelioration
or
boosting
Alzheimer,
Parkinson,
Major
depressive
Anxiety
disorders.
Understanding
relationship
disease
pathophysiology,
mucosal
barrier
function
host-microbe
interaction
foster
use
microbiome
biomarker
for
health
target
therapeutic
nutritional
advances.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 3169 - 3189
Published: April 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
22(1), P. 196 - 196
Published: Dec. 27, 2020
Curcumin
is
a
polyphenolic
natural
compound
with
diverse
and
attractive
biological
properties,
which
may
prevent
or
ameliorate
pathological
processes
underlying
age-related
cognitive
decline,
Alzheimer’s
disease
(AD),
dementia,
mode
disorders.
AD
chronic
neurodegenerative
disorder
that
known
as
one
of
the
rapidly
growing
diseases,
especially
in
elderly
population.
Moreover,
being
eminent
cause
posing
problems
for
families,
societies
well
severe
burden
on
economy.
There
are
no
effective
drugs
to
cure
AD.
Although
curcumin
its
derivatives
have
shown
properties
can
be
considered
useful
inhibiting
hallmarks
AD,
however,
they
low
bioavailability.
Furthermore,
combat
diagnostic
therapeutic
limitations,
various
nanoformulations
also
been
recognized
theranostic
agents
enhance
pharmacokinetic
other
bioactive
compounds.
Nanocarriers
beneficial
deliver
nutritional
compounds
against
blood-brain
barrier
efficiently
distribute
them
brain.
This
review
spotlights
role
effectiveness
Besides,
gut
metabolism
effects
nanoparticles
their
possible
activity
discussed.
