Long Noncoding RNAs in the Pathogenesis of Insulin Resistance DOI Open Access
Weili Yang,

Yixiang Lyu,

Rui Xiang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16054 - 16054

Published: Dec. 16, 2022

Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level insulin, plays crucial roles in development and progression diabetes, nonalcoholic fatty liver disease (NAFLD) other diseases. So far, distinct mechanism(s) IR still needs further exploration. Long non-coding RNA (lncRNA) is a class non-protein coding molecules with length greater than 200 nucleotides. LncRNAs are widely involved many biological processes including cell differentiation, proliferation, apoptosis metabolism. More recently, there has been increasing evidence that lncRNAs participated pathogenesis IR, dysregulated lncRNA profile played important metabolic diseases obesity, diabetes NAFLD. For example, MEG3, H19, MALAT1, GAS5, lncSHGL several have shown regulate signaling glucose/lipid metabolism various tissues. In this review, we briefly introduced general features methods for research, then summarized discussed recent advances on mechanisms particularly focused liver, skeletal muscle adipose

Language: Английский

Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research DOI Open Access
Benchi Ma, Shihao Wang, Wenzheng Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114672 - 114672

Published: April 13, 2023

In recent years, breakthroughs in bioinformatics have been made with the discovery of many functionally significant non-coding RNAs (ncRNAs). The these ncRNAs has further demonstrated multi-level characteristics intracellular gene expression regulation, which plays an important role assisting diagnosis, guiding clinical drug use and determining prognosis treatment process various diseases. microRNAs (miRNAs), long (lncRNAs), circular (circRNAs) are three major types that interact each other. Studies shown lncRNAs circRNAs can sponge miRNAs, thereby influencing normal physiological processes regulating mRNA and, thus, state cells. This paper summarizes mechanism action research progress ncRNA seven modalities. summary is intended to provide new ideas for diagnosing treating diseases researching developing drugs.

Language: Английский

Citations

117
Unveiling the connection: Long-chain non-coding RNAs and critical signaling pathways in breast cancer DOI
Riya Thapa, Obaid Afzal, Gaurav Gupta

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154736 - 154736

Published: Aug. 3, 2023

Language: Английский

Citations

93
MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting DOI
Asif Ahmad Bhat, Obaid Afzal, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154991 - 154991

Published: Nov. 30, 2023

Language: Английский

Citations

74
From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression DOI
Riya Thapa, Obaid Afzal, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154959 - 154959

Published: Nov. 19, 2023

Language: Английский

Citations

62
The complex role of MEG3: An emerging long non-coding RNA in breast cancer DOI Open Access
Md Sadique Hussain,

Abdullah A. Majami,

Ali Haider

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154850 - 154850

Published: Oct. 5, 2023

Language: Английский

Citations

47
Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies DOI Open Access
Subhasree Kumar, Edward A. Gonzalez, Pranela Rameshwar

et al.

Cancers, Journal Year: 2020, Volume and Issue: 12(12), P. 3657 - 3657

Published: Dec. 5, 2020

Non-coding RNAs (ncRNAs) are untranslated RNA molecules that regulate gene expressions. NcRNAs include small nuclear (snRNAs), nucleolar (snoRNAs), ribosomal (rRNAs), transfer (tRNAs), circular (cRNAs) and piwi-interacting (piRNAs). This review focuses on two types of ncRNAs: microRNAs (miRNAs) or short interfering (siRNAs) long non-coding (lncRNAs). We highlight the mechanisms by which miRNAs lncRNAs impact epigenome in context cancer. Both have ability to interact with numerous epigenetic modifiers transcription factors influence expression. The aberrant expression these ncRNAs is associated development progression tumors. primary reason for their deregulated can be attributed alterations. Epigenetic alterations cause misregulation ncRNAs. experimental evidence indicated most abnormally expressed cellular proliferation apoptotic pathways, such changes cancer-dependent. In vitro vivo experiments show that, depending cancer type, either upregulation downregulation prevent Therefore, a better understanding how tumorigenesis could serve develop new therapeutic treatments. Here, we involvement epigenetics use clinical therapy.

Language: Английский

Citations

94
Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases DOI Creative Commons
Miaomiao Chen, Xingning Lai, Xifeng Wang

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2021, Volume and Issue: 14

Published: Oct. 5, 2021

Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia have pro-inflammatory phenotype anti-inflammatory phenotype. Activated activated can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) circular (circRNAs), two groups of (ncRNAs), function as competing endogenous (ceRNAs) impair microRNA (miRNA) inhibition on targeted messenger (mRNAs). LncRNAs circRNAs are involved various disorders. In this review, we summarized that lncRNAs participate dysfunction, astrocyte neuron damage, inflammation. Thereby, positively or negatively regulate diseases, including spinal cord injury (SCI), traumatic brain (TBI), ischemia-reperfusion (IRI), stroke, neuropathic pain, epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), Alzheimer’s (AD). Besides, also found a lncRNA/circRNA-miRNA-mRNA regulatory network mediated Through hope cast light mechanisms diseases provide new insights for treatment.

Language: Английский

Citations

81
NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential DOI Creative Commons
Kun Li,

Tongyue Yao,

Yu Zhang

et al.

International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(13), P. 3428 - 3440

Published: Jan. 1, 2021

The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that upregulated in variety of human cancer types.Increasing evidence has shown the elevation NEAT1 cells promotes cell growth, migration, and invasion inhibits apoptosis.It also known lncRNAs act as competing endogenous (ceRNA) by sponging microRNAs (miRNAs) to alter expression levels their target genes development cancers.Therefore, it important understand molecular mechanisms underlying this observation.In review, specific emphasis was placed on NEAT1's role tumor development.We summarize discuss feedback roles NEAT1/miRNA/target network progression various cancers.As our understanding during tumorigenesis improves, its therapeutic potential biomarker and/or for becomes clearer.

Language: Английский

Citations

69
A novel cuproptosis-related prognostic lncRNA signature and lncRNA MIR31HG/miR-193a-3p/TNFRSF21 regulatory axis in lung adenocarcinoma DOI Creative Commons

Xiaocong Mo,

Di Hu,

Pingshan Yang

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: July 22, 2022

Lung adenocarcinoma (LUAD) remains the most common subtype of lung malignancy. Cuproptosis is a newly identified cell death which could regulate tumor proliferation and progression. Long non-coding RNAs (lncRNAs) are key molecules potential biomarkers for diagnosing treating various diseases. However, effects cuproptosis-related lncRNAs on LUAD still unclear. In our study, 7 were selected to establish prognostic model using univariate Cox regression analysis, LASSO algorithm, multivariate analysis. Furthermore, we evaluated AC008764.2, AL022323.1, ELN-AS1, LINC00578, as protective lncRNAs, while AL031667.3, AL606489.1, MIR31HG risk lncRNAs. The score calculated by proved be an effective independent factor compared with other clinical features analyses [univariate analysis: hazard ratio (HR) = 1.065, 95% confidence interval (CI) 1.043-1.087, P < 0.001; HR 1.067, CI 1.044-1.091, 0.001]. addition, both (ROC nomogram) used corroborate accuracy reliability this signature. correlation between immune microenvironment was elucidated, where cells 8 immune-correlated pathways found differentially expressed two groups. results also verified ceRNA lncRNA MIR31HG/miR-193a-3p/TNFRSF21 regulatory axis bioinformatics tools. highly in specimens some lines. Inhibition clearly reduced proliferation, migration, invasion cells. showed oncogenic via sponging miR-193a-3p tended positively TNFRSF21 expression. word, acts oncogene targeting modulate TNFRSF21, may beneficial gene therapy LUAD.

Language: Английский

Citations

52
Functions of Circular RNA in Human Diseases and Illnesses DOI Creative Commons

Alison Gu,

Dabbu Kumar Jaijyan, Shaomin Yang

et al.

Non-Coding RNA, Journal Year: 2023, Volume and Issue: 9(4), P. 38 - 38

Published: July 4, 2023

Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3′ and 5′ ends provide them more stability than linear RNA, which has free ends. Emerging evidence indicates circRNAs perform essential functions in many DNA viruses, including coronaviruses, Epstein–Barr cytomegalovirus, Kaposi sarcoma viruses. Recent studies have confirmed are present play various important such as evading host immune response, disease pathogenesis, protein translation, miRNA sponges, regulating cell proliferation, virus replication. Studies can be biological signatures or pathological markers for autoimmune diseases, neurological cancers. However, our understanding of viruses is still limited, functional evaluation viral to completely understand their functions. In the review, we describe metabolism cellular roles circRNA, its diseases circRNA found interact with proteins, DNA, thus modulate processes, transcription, splicing, other interfere signaling pathways take part vital biological, physiological, cellular, pathophysiological processes. We also summarize recent demonstrating circRNA’s this growing field research.

Language: Английский

Citations

33