Co-AMPpred for in silico-aided predictions of antimicrobial peptides by integrating composition-based features DOI Creative Commons
Onkar Singh, Wen−Lian Hsu, Emily Chia‐Yu Su

et al.

BMC Bioinformatics, Journal Year: 2021, Volume and Issue: 22(1)

Published: July 30, 2021

Abstract Background Antimicrobial peptides (AMPs) are oligopeptides that act as crucial components of innate immunity, naturally occur in all multicellular organisms, and involved the first line defense function. Recent studies showed AMPs perpetuate great potential is not limited to antimicrobial activity. They also regulators host immune responses can modulate a wide range activities, such regulation, wound healing, apoptosis. However, microorganism's ability adapt resist existing antibiotics triggered scientific community develop alternatives conventional antibiotics. Therefore, address this issue, we proposed Co-AMPpred, an silico-aided AMP prediction method based on compositional features amino acid residues classify non-AMPs. Results In our study, developed incorporates composition-based sequence physicochemical into various machine-learning algorithms. Then, boruta feature-selection algorithm was used identify discriminative biological features. Furthermore, only model. Additionally, performed stratified tenfold cross-validation technique validate predictive performance model evaluated independent holdout test dataset. A benchmark dataset collected from previous evaluate Conclusions Experimental results show combining outperformed methods both training reduced Finally, achieved 80.8% accuracies 0.871 area under receiver operating characteristic curve by evaluating set. Our code datasets available at https://github.com/onkarS23/CoAMPpred .

Language: Английский

Antimicrobial peptides: mechanism of action, activity and clinical potential DOI Creative Commons
Qiyu Zhang,

Zhibin Yan,

Yueming Meng

et al.

Military Medical Research, Journal Year: 2021, Volume and Issue: 8(1)

Published: Sept. 9, 2021

Abstract The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution antibiotic resistant bacteria. As an excellent candidate overcome resistance, antimicrobial peptides (AMPs) that are produced from synthetic and natural sources demonstrate broad-spectrum activity with high specificity low toxicity. These possess distinctive structures functions by employing sophisticated mechanisms action. This comprehensive review provides broad overview AMPs origin, structural characteristics, action, biological activities applications. We finally discuss strategies optimize develop AMP-based treatment as potential anticancer therapeutics.

Language: Английский

Citations

745
Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields DOI Creative Commons
Antonio Moretta, Carmen Scieuzo,

Anna Maria Petrone

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: June 14, 2021

Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use contributes the development and spread of drug-resistant microorganisms. Antibiotic resistance is a serious challenge has led need for new alternative molecules less prone bacterial resistance. Antimicrobial peptides (AMPs) have aroused great interest as potential next-generation antibiotics, since they bioactive small proteins, naturally produced by all living organisms, representing first line defense against fungi, viruses bacteria. AMPs commonly classified according sources, which represented microorganisms, plants animals, well secondary structure, biosynthesis mechanism action. They find application in different fields such agriculture, food industry medicine, on we focused our attention this review. Particularly, examined AMP applicability wound healing, skin infections metabolic syndrome, considering ability act Angiotensin-Converting Enzyme I pancreatic lipase inhibitory antioxidant peptides. Moreover, argued about pharmacokinetic pharmacodynamic approaches develop drug strategies formulation be taken into account developing clinically suitable applications.

Language: Английский

Citations

378
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections DOI

Yiyun Zhu,

Weijing Hao,

Xia Wang

et al.

Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 42(4), P. 1377 - 1422

Published: Jan. 4, 2022

Antimicrobial peptides (AMPs), also known as host defense (HDPs), are important effector immune molecules in multicellular organisms. AMPs exert their antimicrobial activities through several mechanisms; thus far, induction of drug resistance has been regarded unlikely. Therefore, they have great potential new generation agents. To date, more than 30 AMP-related drugs the clinical trial phase. In recent years, studies show that some and conventional antibiotics synergistic effects. The combined use can kill drug-resistant pathogens, prevent resistance, significantly improve therapeutic effects antibiotics. this review, we discuss progress on An overview current understanding functional scope AMPs, ongoing trials, challenges development processes presented.

Language: Английский

Citations

170
Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides DOI Creative Commons
Xin Li,

Siyao Zuo,

Wang Bin

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2675 - 2675

Published: April 21, 2022

Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and components the innate immunity almost all living things. They play an important role resisting foreign invading microorganisms. have wide range antibacterial activities against bacteria, fungi, viruses other active traditional antibiotic-resistant strains do not easily induce development drug resistance. Therefore, they become hot spot medical research expected to new substitute for fighting microbial infection represent method treating drug-resistant bacteria. This review briefly introduces source structural characteristics antimicrobial describes those been used common clinical microorganisms (bacteria, viruses, especially coronaviruses), focusing on their mechanism action application prospects.

Language: Английский

Citations

119
Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens DOI Creative Commons
Yosra A. Helmy,

Khaled Taha-Abdelaziz,

Hanan Abd El-Halim Hawwas

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 274 - 274

Published: Jan. 30, 2023

Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use antibiotics in humans and animals has resulted emergence antibiotic-resistant bacteria. dissemination these strains their resistant determinants could endanger antibiotic efficacy. Therefore, there an urgent need to identify develop novel strategies combat resistance. This review provides insights into evolution mechanisms AMR. Additionally, it discusses alternative approaches that might be used control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, nanoparticles.

Language: Английский

Citations

108
Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health DOI Creative Commons
Ting Li, Zhenlong Wang, Jianhua Guo

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 860, P. 160461 - 160461

Published: Nov. 24, 2022

Language: Английский

Citations

90
Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health DOI Creative Commons
Dai‐Xu Wei, Xu-Wei Zhang

Biosafety and Health, Journal Year: 2022, Volume and Issue: 4(2), P. 118 - 134

Published: Feb. 26, 2022

Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their broad-spectrum resistance to bacteria, fungi, viruses and parasites, influencing host immune responses. AMPs attributed good biological effects have been used in various areas of human health, which trying completely replace antibiotics, owing serious drug-resistance bacteria. However, limited bioactivity potential biotoxicity some was neglected, attributable hydrophobic structure with positive charges nonspecific destruction cell membranes. Various strategies design biosynthetic optimized improve bioactivity, productivity, while lowering toxicity cost. Here, we focus on progress made understanding AMPs, including biosynthesis (AMP-BioDesign 1.0 2.0), (e.g. regulation or actions against parasites), principle hemolysis, acute instability, ect). The application prospects AMP clinical medicine (for novel drugs), tissue engineering drug delivery system, respectively, summarized this review. Furthermore, future new strategy development effective low-toxic formulations health discussed.

Language: Английский

Citations

72
Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use DOI Open Access
Anna Mazurkiewicz-Pisarek, Joanna Baran, Tomasz Ciach

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 9031 - 9031

Published: May 20, 2023

Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life forms. Here we discuss AMPs, which may become a promising substitute adjuvant pharmaceutical, biomedical, and cosmeceutical uses. Their pharmacological potential has been investigated intensively, especially as antibacterial antifungal drugs antiviral anticancer agents. AMPs exhibit many properties, some of these have attracted the attention cosmetic industry. being developed novel antibiotics to combat multidrug-resistant pathogens treatments for diseases, including cancer, inflammatory disorders, viral infections. In biomedicine, wound-healing agents because they promote cell growth tissue repair. The immunomodulatory effects could be helpful treatment autoimmune diseases. industry, ingredients skincare products due their antioxidant properties (anti-ageing effects) activity, allows killing bacteria that contribute acne other skin conditions. benefits make them thrilling area research, studies underway overcome obstacles fully harness therapeutic potential. This review presents structure, mechanisms action, possible applications, production methods, market AMPs.

Language: Английский

Citations

69
Ion-Doped Calcium Phosphate-Based Coatings with Antibacterial Properties DOI Creative Commons
Marco Fosca,

Alexandru Streza,

Iulian Antoniac

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(5), P. 250 - 250

Published: April 29, 2023

Ion-substituted calcium phosphate (CP) coatings have been extensively studied as promising materials for biomedical implants due to their ability enhance biocompatibility, osteoconductivity, and bone formation. This systematic review aims provide a comprehensive analysis of the current state art in ion-doped CP-based orthopaedic dental implant applications. Specifically, this evaluates effects ion addition on physicochemical, mechanical, biological properties CP coatings. The also identifies contribution additional (in separate or synergistic way) different components used together with advanced composite In final part, antibacterial specific bacteria strains are reported. present could be interest researchers, clinicians, industry professionals involved development application implants.

Language: Английский

Citations

36
Antimicrobial Peptides and Cell-Penetrating Peptides: Non-Antibiotic Membrane-Targeting Strategies Against Bacterial Infections DOI Creative Commons

Xucheng Huang,

Guoli Li

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 1203 - 1219

Published: Feb. 1, 2023

The prevalence of antimicrobial resistance (AMR) has been rising quickly in recent years. AMR emerged as a significant obstacle to the treatment infectious diseases, and many attempts have made over past decades find best antimicrobials overcome it. Therefore, it is crucial new medicines combat global rise AMR. Antimicrobial peptides (AMPs) cell-penetrating (CPPs), which target membranes, are promising antibiotic substitutes. AMPs CPPs short amino acid sequences with antibacterial activity well possible therapeutic benefits. In this review, we provide thorough systematic introduction advancement research on CPPs, including information their classification, mechanism action, current state application, limitations optimization.

Language: Английский

Citations

34