Biological macromolecule-based hydrogels with antibacterial and antioxidant activities for wound dressing: A review DOI Creative Commons

Tayebeh Zivari-Ghader,

Mohammad‐Reza Rashidi, Mehdi Mehrali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 134578 - 134578

Published: Aug. 8, 2024

Because of the complex symptoms resulting from metabolic dysfunction in wound microenvironment during bacterial infections, along with necessity to combat free radicals, achieving prompt and thorough healing remains a significant medical challenge that has yet be fully addressed. Moreover, misuse common antibiotics contributed emergence drug-resistant bacteria, underscoring need for enhancements practical commonly utilized approach treatment. In this context, hydrogel dressings based on biological macromolecules antibacterial antioxidant properties present promising new avenue skin treatment due their multifunctional characteristics. Despite considerable potential innovative care, comprehensive research these is still insufficient. Consequently, development advanced macromolecule-based hydrogels, such as chitosan, alginate, cellulose, hyaluronic acid, others, been primary focus study. These materials have enriched various agents confer attributes purposes. This review article aims offer overview latest progress field, providing critical theoretical basis future advancements utilization hydrogels healing.

Language: Английский

Modern Wound Dressings: Hydrogel Dressings DOI Creative Commons

Valentin Brumberg,

Т. А. Астрелина, T. F. Malivanova

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(9), P. 1235 - 1235

Published: Sept. 16, 2021

Chronic wounds do not progress through the wound healing process in a timely manner and are considered burden for healthcare system; they also most common reason decrease patient quality of life. Traditional dressings e.g., bandages gauzes, although highly absorbent effective dry to mild, exudating wounds, require regular application, which therefore can cause pain upon dressing change. In addition, have poor adhesional properties cannot provide enough drainage wound. this regard, normalization chronic is an extremely urgent task public health requires creation implementation affordable patients with wounds. Modern (WDs) aimed solve these issues. At same time, hydrogels, unlike other types modern WDs (foam, films, hydrocolloids), positive degradation that makes them perfect choice applications where targeted delivery bioactive substances required. This mini review focused on different traditional emphasis hydrogels. Advantages disadvantages as well their applicability elucidated. Furthermore, effectiveness comparison between hydrogel some frequently used biotechnologies field regenerative medicine (adipose-derived mesenchymal stem cells (ADMSCs), cells, conditioned media, platelet-rich plasma (PRP)) provided.

Language: Английский

Citations

272
Role of copper nanoparticles in wound healing for chronic wounds: literature review DOI Creative Commons
Jessica Salvo, Cristian Sandoval

Burns & Trauma, Journal Year: 2021, Volume and Issue: 10

Published: Nov. 22, 2021

Chronic wounds are defined as that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common inevitable impairment is installation infection, usually case chronic wounds. Therefore, objective present review was identify importance copper nanoparticles dressings for healing. Nanoparticles such silver, gold combat infectious processes inhibition protein synthesis, peroxidation cell membrane destroying nucleic acids bacteria viruses. Among bioactive nanoparticles, plays a complex role various cells, it modulates several cytokines growth factor mechanisms action essentially involved all stages process. More importantly, key skin regeneration angiogenesis accelerates process induction vascular endothelial (VEGF) by hypoxia-induced factor-1-alpha (HIF-1α) where enhances HIF-1α expression binding critical motifs promoter putative enhancer regions HIF-1-regulated genes.

Language: Английский

Citations

116
Multifunctional Hydrogels for the Healing of Diabetic Wounds DOI
Tao Xiang,

Qianru Guo,

Lianghao Jia

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Language: Английский

Citations

113
A critical review on the bio-mediated green synthesis and multiple applications of magnesium oxide nanoparticles DOI

Ngoan Thi Thao Nguyen,

Luan Minh Nguyen, Thuy Thi Thanh Nguyen

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 312, P. 137301 - 137301

Published: Nov. 18, 2022

Language: Английский

Citations

74
Polysaccharide-based hydrogels: New insights and futuristic prospects in wound healing DOI
Neha Raina, Rakesh Pahwa, Vijay Kumar Thakur

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 223, P. 1586 - 1603

Published: Nov. 14, 2022

Language: Английский

Citations

71
Advances in preparation and application of antibacterial hydrogels DOI Creative Commons

Yixin Tang,

Huiqing Xu,

Xue Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 26, 2023

Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents reduce the problem of antibiotics. Biomedical materials with good antimicrobial properties been widely used in applications. Among them, hydrogels become focus research field biomedical due their unique three-dimensional network structure, high hydrophilicity, biocompatibility. In this review, latest progresses about recent years were summarized, mainly including preparation methods According different mechanisms, several representative introduced, such as antibiotics loaded hydrogels, antibiotic-free metal-based peptide polymers, stimuli-responsive smart light-mediated hydrogels. addition, we also discussed applications challenges biomedicine, which are expected provide directions ideas for application clinical therapy.

Language: Английский

Citations

65
Preparation and characterization of lotus root starch based bioactive edible film containing quercetin-encapsulated nanoparticle and its effect on grape preservation DOI

Ya-Fan Zeng,

Ying‐Ying Chen, Yuanyuan Deng

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121389 - 121389

Published: Sept. 12, 2023

Language: Английский

Citations

56
Fabrication of CuO nanoparticles embedded novel chitosan/hydroxypropyl cellulose bio-nanocomposites for active packaging of jamun fruit DOI

Manjushree Nagaraj Gunaki,

Saraswati P. Masti,

Oshin Jacintha D’souza

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 152, P. 109937 - 109937

Published: March 3, 2024

Language: Английский

Citations

25
On-Site Electrospinning Nanofiber Membranes Incorporating V-Shaped Organic Semiconductors for Multifunctional Diabetic Wound Dressing DOI

Ling Hong,

Pu Qiu,

Shining Niu

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(5), P. 1413 - 1427

Published: May 7, 2024

Language: Английский

Citations

18
Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances DOI Open Access
V. Gopinath, S. Manjunath Kamath,

S. Priyadarshini

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 146, P. 112492 - 112492

Published: Dec. 11, 2021

The emergence of clinical complications and therapeutic challenges for treating various diseases necessitate the discovery novel restorative functional materials. Polymer-based drug delivery systems have been extensively reported in last two decades. Recently, there has an increasing interest progression natural biopolymers based controlled strategies, especially tissue engineering applications. However, solubility functionalisation due to their complex network structure intramolecular bonding seem challenging. This review explores current advancement prospects most promising polymers such as cellulose, starch derivatives-based vehicles like hydrogels, films composites, combating major ailments bone infections, microbial cancers. In addition, selective targeting using metal-drug (MD) MD-based polymeric missiles exciting but challenging its application cancer therapeutics. Owing high biocompatibility these materials evaluated biomedical pharmaceutical presents a detailed impression trends construction biopolymer-based engineering, drug/gene/protein vehicles.

Language: Английский

Citations

75