Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

Journal of Immunology Research, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 11

Published: July 23, 2021

The prevalence of inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s (CD), increases gradually worldwide in the past decades. IBD is generally associated with change immune system gut microbiota, conventional treatments usually result some side effects. Bifidobacterium longum, as colonizing bacteria intestine, has been demonstrated to be capable relieving mice can employed an alternative or auxiliary way for treating IBD. Here, mechanisms longum treatment were summarized based on previous cell animal studies clinical trials testing bacterial therapies. This review will served a basis future research treatment.

Language: Английский

---

TNF in the liver: targeting a central player in inflammation

Seminars in Immunopathology, Journal Year: 2022, Volume and Issue: 44(4), P. 445 - 459

Published: Feb. 4, 2022

Abstract Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces of solid tumours, TNF became increasingly important pro-inflammatory cytokine being involved in the immunopathogenesis several autoimmune diseases. In liver, numerous biological responses such hepatocyte apoptosis and necroptosis, liver inflammation regeneration, autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions we propose anti-TNF therapies specifically target signalling at level its specific receptors.

Language: Английский

---

Noise-Induced Hearing Loss

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(6), P. 2347 - 2347

Published: March 17, 2023

Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural loss, after age-related and affects approximately 5% world’s population. NIHL associated with substantial physical, mental, social, economic impacts at patient societal levels. Stress social isolation in patients’ workplace personal lives contribute to quality-of-life decrements which may often go undetected. The pathophysiology multifactorial complex, encompassing genetic environmental factors occupational contributions. diagnosis screening are conducted by reviewing a patient’s history noise exposure, audiograms, speech-in-noise test results, measurements distortion product otoacoustic emissions auditory brainstem response. Essential aspects decreasing burden prevention early detection, such as implementation educational programs routine primary care specialty clinics. Additionally, current research on pharmacological treatment includes anti-inflammatory, antioxidant, anti-excitatory, anti-apoptotic agents. Although there have been advances understanding NIHL, remain low levels evidence for effective pharmacotherapeutic interventions. Future directions should include personalized targeted strategies based holistic view an individual’s occupation, genetics, pathology.

Language: Английский

---

Pathogenesis and treatment of Sjogren’s syndrome: Review and update

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Sjogren’s syndrome (SS) is a chronic autoimmune disease accompanied by multiple lesions. The main manifestations include dryness of the mouth and eyes, along with systemic complications (e.g., pulmonary disease, kidney injury, lymphoma). In this review, we highlight that IFNs, Th17 cell-related cytokines (IL-17 IL-23), B (TNF BAFF) are crucial for pathogenesis SS. We also summarize advances in experimental treatment strategies, including targeting Treg/Th17, mesenchymal stem cell treatment, BAFF, inhibiting JAK pathway, et al. Similar to SLE, RA, MS, biotherapeutic strategies SS consist neutralizing antibodies inflammation-related receptor blockers proinflammatory signaling pathways. However, clinical research on therapy comparatively rare. Moreover, differences curative effects immunotherapies among other diseases not fully understood. emphasize targeted drugs, low-side-effect combination therapies should be focus future research.

Language: Английский

---

Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 7, 2023

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the TNF superfamily of receptor ligands. The exists as either transmembrane or soluble molecule, and targets two distinct receptors, TNF-α 1 (TNFR1) 2 (TNFR2), which activate different signaling cascades downstream genes. cellular responses depend on its molecular form, targeted receptor, concentration levels. plays multifaceted role in normal physiology highly relevant human health disease. In central nervous system (CNS), this regulates homeostatic functions, such neurogenesis, myelination, blood-brain barrier permeability synaptic plasticity. However, it can also potentiate neuronal excitotoxicity CNS inflammation. pleiotropism various roles CNS, whether deleterious, only emphasizes functional complexity cytokine. Anti-TNF-α therapy has demonstrated effectiveness treating autoimmune inflammatory diseases emerged significant treatment option for diseases. Nevertheless, crucial recognize effects therapeutic target are diverse complex. Contrary initial expectations, anti-TNF-α been found have detrimental multiple sclerosis. This article focuses describing roles, both physiological pathological, CNS. Additionally, discusses specific disease processes dependent regulated by rationale use target.

Language: Английский

---

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 23, 2022

Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including their immunosuppressive and immunomodulatory properties as well ability to improve tissue regeneration, these have attracted attention scientists clinicians for treatment different inflammatory immune system mediated disorders. However, various clinical trials using MSCs purpose are conflicting differ from results promising preclinical studies. This inconsistency is caused by several factors such poor migration homing capacities, low survival rate, level proliferation differentiation, donor-dependent variation cells. Enhancement retention persistent effects remain a challenge overcome in MSC-based therapy. In this review, we summarized approaches enhance outcomes therapy revised current future perspectives creation cellular products with improved diverse applications.

Language: Английский

---

Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6142 - 6142

Published: March 24, 2023

The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of 2020 and has affected millions. Several previous studies revealed impact imbalanced innate immune response on progression COVID-19 its outcomes. High levels proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) interleukins are produced readily by cells to fight Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infections. Nonetheless, cytokine-mediated inflammatory events also linked detrimental lung injury respiratory failure, which can result in deaths among patients. TNF-α is amongst early mediate responses enhance cell infiltration SARS-CoV-2 In COVID-19, TNF-α-mediated inflammation cause tissue damage gradually promotes fibrosis, later results pneumonia, pulmonary edema, acute distress syndrome. This review, therefore, aims deliberate immunomodulatory roles promoting relation with morbidity mortality. addition, this review proposes potential biomarker for prognosis severe related complications molecular target anti-TNF-α therapy.

Language: Английский

---

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Feb. 24, 2023

Abstract Sarcopenia has become a leading cause of disability and mortality in the elderly. It been reported that programmed cell death (PCD) is associated with development sarcopenia characterized by reduction muscle fiber size number. TNF-α also validated to play prominent role through its complex signaling pathways including signaling. However, it still unclear whether contributes mediating pyroptosis, one type PCD. Here, we first established naturally aged mice model confirmed an inflammatory state represented mice. Evidence GSDME-mediated pyroptosis activation apoptotic caspase-8/-3 were found skeletal cells sarcopenia. We demonstrated triggered myotubes activating caspase-8 caspase-3 using inhibitors. Comparing GSDME expression between TNF Complex IIa IIb, was be more inclined assemble IIb triggering pyroptosis. Moreover, pyroptotic result decreased MHC1 finally loss knockdown GSDME. Our work reveals novel mechanism TNF-ɑ/caspase-8/caspase-3/GSDME signaling-mediated Caspase-3/GSDME may promising therapeutic target for

Language: Английский

---

Targeting inflammation as cancer therapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: March 22, 2024

Abstract Inflammation has accompanied human beings since the emergence of wounds and infections. In past decades, numerous efforts have been undertaken to explore potential role inflammation in cancer, from tumor development, invasion, metastasis resistance tumors treatment. Inflammation-targeted agents not only demonstrate suppress cancer but also improve efficacy other therapeutic modalities. this review, we describe highly dynamic complex inflammatory microenvironment, with discussion on key mediators including cells, cytokines, their downstream intracellular pathways. addition, especially address development highlight action mechanisms inflammation-targeted therapies antitumor response. Finally, summarize results both preclinical clinical studies up date illustrate translation therapies.

Language: Английский

---

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

Language: Английский

---