A review of potential human health impacts of micro- and nanoplastics exposure

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 851, P. 158111 - 158111

Published: Aug. 17, 2022

This systematic review aims to summarize the current knowledge on biological effects of micro- and nanoplastics (MNPs) human health based mammalian systems. An extensive search literature led a total 133 primary research articles relevance MNPs. Our findings revealed that although study MNP cytotoxicity inflammatory response represents major theme, most studies (105 articles) focused polystyrene MNPs due their wide availability as well characterised material can be manufactured with large range particle sizes, fluorescence labelling various surface modifications. Among covered in this review, 117 reported adverse after being exposed Mammalian vitro identified multiple including cytotoxicity, oxidative stress, response, genotoxicity, embryotoxicity, hepatotoxicity, neurotoxicity, renal toxicity even carcinogenicity, while rodent vivo models confirmed bioaccumulation liver, spleen, kidney, brain, lung gut, presenting at different levels reproductive toxic trans-generational toxicity. In contrast, remaining 16 indicated an insignificant impact humans. A few attempted investigate mechanisms or factors driving several determining size, concentration, shape, charge, attached pollutants weathering process, which, however, were not benchmarked considered by studies. demonstrates there are still many inconsistencies evaluation potential lack comparability between Current limitations hindering attainment reproducible conclusions recommendations for future directions also presented.

Language: Английский

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Coronas of micro/nano plastics: a key determinant in their risk assessments

Particle and Fibre Toxicology, Journal Year: 2022, Volume and Issue: 19(1)

Published: Aug. 6, 2022

Abstract As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are increasingly being released into natural environment. Substantial concerns have been raised regarding environmental and health impacts M/NPs. Although diverse M/NPs detected environment, most them display two similar features, i.e.,high surface area strong binding affinity, which enable extensive interactions between surrounding substances. This results formation coronas, including eco-coronas bio-coronas, on different media. In real exposure scenarios, corona is inevitable often displays variable complex structures. The coronas found to impact transportation, uptake, distribution, biotransformation toxicity particulates. Different from conventional toxins, packages rather than bare particles more dangerous. We, therefore, recommend seriously consideration role safety assessments. review summarizes recent progress eco–coronas bio-coronas M/NPs, further discusses analytical methods interpret structures, highlights provides future perspectives.

Language: Английский

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Mechanism and characterization of microplastic aging process: A review

Frontiers of Environmental Science & Engineering, Journal Year: 2023, Volume and Issue: 17(8)

Published: March 14, 2023

Language: Английский

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Microplastics role in cell migration and distribution during cancer cell division

Chemosphere, Journal Year: 2024, Volume and Issue: 353, P. 141463 - 141463

Published: Feb. 27, 2024

Amidst the global plastic pollution crisis, gastrointestinal tract serves as primary entry point for daily exposure to micro- and nanoplastics. We investigated complex dynamics between polystyrene nanoplastics (PS-MNPs) four distinct human colorectal cancer cell lines (HT29, HCT116, SW480, SW620). Our findings revealed a significant size- concentration dependent uptake of 0.25, 1, 10 μm PS-MNPs across all lines, with HCT116 cells exhibiting highest rates. During division, particles were distributed mother daughter cells. Interestingly, we observed no signs elimination from Short-term 0.25 significantly amplified migration, potentially leading pro-metastatic effects. Particles demonstrated high persistence in 2D 3D cultures, accumulation non-proliferating parts spheroids, without interfering proliferation or division. study unveils disturbing fact bioaccumulation MNPs key toxicological traits under REACH (Regulation concerning Registration, Evaluation, Authorisation Restriction Chemicals). observations underscore potential hidden catalysts tumor progression, particularly through enhancing migration possibly fueling metastasis - finding that sheds light on previously underexplored area concern.

Language: Английский

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Recent advances and future technologies in nano-microplastics detection

Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 8, 2025

The degradation of mismanaged plastic waste in the environment results formation microplastics (MPs) and nanoplastics (NPs), which pose significant risks to ecosystems human health. These particles are pervasive, detected even remote regions, can enter food chain, accumulating organisms causing harm depending on factors such as particle load, exposure dose, presence co-contaminants. Detecting analyzing NMPs present unique challenges, particularly size decreases, making them increasingly difficult identify. Moreover, absence standardized protocols for their detection analysis further hinders comprehensive assessments environmental biological impacts. This review provides a detailed overview latest advancements technologies sampling, separation, measurement, quantification NMPs. It highlights promising approaches, supported by practical examples from recent studies, while critically addressing persistent challenges characterization, analysis. work examines cutting-edge developments nanotechnology-based detection, integrated spectro-microscopic techniques, AI-driven classification algorithms, offering solutions bridge gaps NMP research. By exploring state-of-the-art methodologies presenting future perspectives, this valuable insights improving capabilities at micro- nanoscale, enabling more effective across diverse contexts.

Language: Английский

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Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs

NanoImpact, Journal Year: 2023, Volume and Issue: 32, P. 100481 - 100481

Published: Sept. 16, 2023

Language: Английский

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Origin, ecotoxicity, and analytical methods for microplastic detection in aquatic systems

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117392 - 117392

Published: Nov. 14, 2023

Language: Английский

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Artificial intelligence-empowered collection and characterization of microplastics: A review

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134405 - 134405

Published: April 26, 2024

Language: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

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Do’s and don’ts of microplastic research: a comprehensive guide

Water Emerging Contaminants & Nanoplastics, Journal Year: 2024, Volume and Issue: 3(21)

Published: March 4, 2024

Microplastics are environmental contaminants consisting of small plastics ≤ 5 mm. Concerns over the adverse effects microplastics have led to a rapid growth in available literature despite lack harmonized methods and materials. Therefore, field is becoming increasingly daunting new researchers. A state-of-the-art guide was assembled following comprehensive review research with intent addressing contemporary challenges, prioritized based on survey, introducing best practices. The standardized reference materials, access analytical equipment, difficulty working lower concentrations laboratory tests (e.g., toxicity assays) remain great challenge. present work addresses these issues across three main sections: definitions, sampling, evaluation effects. Harmonized greater collaboration were identified as opportunities this rapidly evolving field. interlaboratory comparison also conducted support additional recommendations.

Language: Английский

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