Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 109204 - 109204
Published: May 16, 2024
Language: Английский
NPG Asia Materials, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 19, 2024
Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent impairment in patients. Unfortunately, due complex pathological mechanisms and unique postinjury microenvironment, there is currently no way completely repair injured cord. In recent years, with rapid development tissue engineering technology, combination biomaterials medicine has provided a new idea for treating SCI. Here, we systematically summarize representative biomaterials, including natural, synthetic, nano, hybrid materials, their applications SCI treatment. addition, describe several state-of-the-art fabrication techniques engineering. Importantly, provide novel insights use biomaterial-based therapeutic strategies reduce secondary damage promote repair. Finally, discuss biomaterial clinical studies. This review aims reference future exploration regeneration strategies.
Language: Английский
Citations
23
Heliyon, Journal Year: 2022, Volume and Issue: 8(12), P. e12193 - e12193
Published: Dec. 1, 2022
Language: Английский
Citations
51
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)
Published: March 21, 2023
Short designer self-assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide diverse and robust toolbox for surgeons integrate wound microenvironment with much safer stronger hemostatic capacity than conventional materials agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, internal medical bleeding (IMB), respect optimal formulation, dSAP ingenious nanofiber alternatives make bioactive neural scaffold, nasal packing, large coverage gastrointestinal surgery (esophagus, gastric lesion, duodenum, lower digestive tract), epicardiac cell-delivery carrier, transparent matrix barrier, so on. Herein, multiple surgical specialties, dSAP-biomaterial-based nano-hemostats achieve safe, effective, immediate hemostasis, facile healing, potentially reduce risks delayed rebleeding, post-operative or related complications. The biosafety vivo, indications, tissue-sealing quality, feasibility, local usability addressed comprehensively sequentially pursued develop useful techniques better performance. Here, state of art all-round advancements nano-hemostatic approaches provided. Relevant critical insights will inspire exciting investigations on nanotechnology, next-generation biomaterials, promising prospects clinics.
Language: Английский
Citations
33
International Journal of Extreme Manufacturing, Journal Year: 2023, Volume and Issue: 5(3), P. 032008 - 032008
Published: June 13, 2023
Abstract Because of the complex nerve anatomy and limited regeneration ability natural tissue, current treatment effect for long-distance peripheral spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering a promising method to regenerate cord, can provide structures functions similar tissues through scaffold materials seed cells. Recently, rapid development 3D printing technology enables researchers create novel constructs with sophisticated diverse achieve high bionics functions. In this review, we first outlined as well strategies SCI in clinical. After that, design considerations were discussed, various technologies applicable neural elaborated, including inkjet, extrusion-based, stereolithography, projection-based, emerging technologies. Finally, focused on application repair, challenges prospects research field.
Language: Английский
Citations
28
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: May 31, 2023
Spinal cord injury (SCI) is a disease of the central nervous system often caused by accidents, and its prognosis unsatisfactory, with long-term adverse effects on patients’ lives. The key to treatment lies in improvement microenvironment at reconstruction axons, tissue repair promising therapeutic strategy. Hydrogel three-dimensional mesh structure high water content, which has advantages biocompatibility, degradability, adjustability, can be used fill pathological defects injectable flowing hydrophilic material situ accurately adapt size shape injury. Hydrogels mimic natural extracellular matrix for cell colonization, guide axon extension, act as biological scaffold, an excellent carrier participate SCI. addition different materials make composite hydrogel scaffolds further enhance their performance all aspects. In this paper, we introduce several typical hydrogels review research progress SCI provide reference clinical application therapy
Language: Английский
Citations
23
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Spinal cord injury (SCI) can cause irreversible trauma to nervous tissue, leading permanent damage the patient's motor and sensory functions. Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) simulate most of functions MSCs are considered an ideal treatment option for SCI. However, potential mechanism MSC-EVs SCI still needs be explored. We cultured neurons in vitro investigate effect miR-124 on p62-Keap1-Nrf2 pathway. Besides, containing were injected into a rat spinal model observe their neural repair effect. The accumulation p62 reversed by miR-124, which promotes autophagy alleviates oxidative stress, thereby exerting neuroprotective effects. Rats who received injection overexpressing after surgery showed higher BBB scores, lower levels cell apoptosis, better tissue morphology. Our results indicated that stabilize loop, promoting alleviating stress exert research proposes novel target treating
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162124 - 162124
Published: March 1, 2025
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2022, Volume and Issue: 16, P. 100434 - 100434
Published: Sept. 20, 2022
Repairing critical bone defects is a complex problem in the clinic. The periosteum rich nerve plays vital role initiating and regulating regeneration. However, current studies have paid little attention to repairing nerves promote Thus, it essential construct bionic with targeted injured periosteum. We coupled phosphatidylserine (PS) aptamers repair Schwann cell exosomes exosome@aptamer (EA). Then through PEI, EA was successfully built on surface of electrospun fiber, which PCL@PEI@exosome@aptamer (PPEA). Through SEM, TEM, other technologies, PPEA characterized. Experiments prove vivo vitro that has an excellent effect damaged regeneration vascular bones. In vivo, we confirmed biomimetic apparent ability by using Microcomputer tomography, hematoxylin-eosin, Masson, Immunofluorescence. vitro, used Immunofluorescence, Real-Time Quantitative PCR, Alkaline phosphatase staining, tests confirm central nerve, blood vessel, ability. neurogenic, angiogenic, osteogenic effects. will provide promising method for treating defects.
Language: Английский
Citations
33
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(17)
Published: March 5, 2023
Peripheral nerve defects are a worldwide problem, and autologous transplantation is currently the gold-standard treatment for them. Tissue-engineered (TEN) grafts widely considered promising methods same, have attracted much attention. To improve repair, incorporation of bionics into TEN has become focus research. In this study, novel bionic graft with biomimetic structure composition designed. For purpose, chitin helical scaffold fabricated by means mold casting acetylation using chitosan as raw material, following which fibrous membrane electrospun on outer layer scaffold. The lumen filled human bone mesenchymal stem cell-derived extracellular matrix fibers to provide nutrition topographic guidance, respectively. prepared then transplanted bridge 10 mm sciatic in rats. Morphological functional examination shows that repair effects autografts similar. described study great potential application offers new way clinical peripheral defects.
Language: Английский
Citations
18
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(18), P. 2528 - 2528
Published: Sept. 10, 2023
Injuries to the peripheral nervous system are a common clinical issue, causing dysfunctions of motor and sensory systems. Surgical interventions such as nerve autografting necessary repair damaged nerves. Even with autografting, i.e., gold standard, malfunctioning mismatches between injured donor nerves often lead unwanted failure. Thus, there is an urgent need for new intervention in practice achieve full functional recovery. Nerve guidance conduits (NGCs), providing physicochemical cues guide neural regeneration, have great potential regeneration Typically, NGCs tubular structures various configurations create microenvironment that induces oriented accelerated growth axons promotes neuron cell migration tissue maturation within tissue. Once native environment better understood, ideal should maximally recapitulate those key physiological attributes regeneration. Indeed, NGC design has evolved from solely physical biochemical stimulation. fabrication requires fundamental considerations distinct structures, associated extracellular compositions (extracellular matrices, factors, cytokines), cellular components, advanced technologies can mimic structure morphology matrices. this review mainly summarizes recent advances state-of-the-art terms biomaterial innovations, structural design, provides in-depth discussion responses (adhesion, spreading, alignment) biomimetic repair.
Language: Английский
Citations
18