Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

Children, Journal Year: 2022, Volume and Issue: 9(7), P. 1014 - 1014

Published: July 8, 2022

The oral microbiota plays a vital role in the human microbiome and health. Imbalances between microbes their hosts can lead to systemic disorders such as diabetes or cardiovascular disease. purpose of this review is investigate literature evidence dysbiosis on health discuss current knowledge emerging mechanisms governing polymicrobial synergy dysbiosis; both have enhanced our understanding pathogenic aided design innovative therapeutic approaches ORALBIOTICA for diseases demineralization. PubMed, Web Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, PsyArticles, DRUGS@FDA were searched publications that matched topic from January 2017 22 April 2022, with an English language constraint using following Boolean keywords: ("microbio*" "demineralization*") AND ("oral microbiota" "demineralization"). Twenty-two studies included qualitative analysis. As seen by review, balance unstable influenced hygiene, presence orthodontic devices cavity poor eating habits modify its composition behavior positive negative ways, increasing development demineralization, caries processes, periodontal Under conditions dysbiosis, favored acidic environment, reproduction specific bacterial strains increases, favoring cariogenic ones Bifidobacterium dentium, longum,

Language: Английский

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Microbial transformation of dietary xenobiotics shapes gut microbiome composition

Cell, Journal Year: 2024, Volume and Issue: 187(22), P. 6327 - 6345.e20

Published: Sept. 24, 2024

Language: Английский

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Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(3), P. 132 - 132

Published: Feb. 27, 2023

Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim this study is evaluate effectiveness tooth as a grafting material examine properties its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, Web Science were searched find articles addressing our topic published 1 January 2012 up 22 November 2022, total 1516 studies identified. Eighteen papers in all considered review qualitative analysis. Demineralized dentin can be used graft material, since it shows high cell compatibility promotes rapid by striking an ideal balance between resorption production; also has several benefits, such quick recovery times, high-quality newly formed bone, low costs, no risk disease transmission, ability performed outpatient procedure, donor-related postoperative complications. Demineralization crucial step treatment process, which includes cleaning, grinding, demineralization. Since presence hydroxyapatite crystals prevents release growth factors, demineralization essential effective regenerative surgery. Even though relationship system dysbiosis not yet fully explored, highlights association gut microbes. creation additional scientific build upon enhance findings should future objective research.

Language: Английский

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The Benefits of Probiotics on Oral Health: Systematic Review of the Literature

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1313 - 1313

Published: Sept. 16, 2023

Aim: Probiotic microorganisms, commonly used to bolster gut health, might also have benefits for dental according certain studies. Probiotics (PBs) are associated with reducing cariogenic pathogens and protecting against periodontal diseases, although the exact way they function in mouth is not fully clear. Our study aimed explore use of PBs improve oral focusing on issues such as cavities, gum disease, bad breath, mucositis, periimplantitis. Materials Methods: We utilized Boolean keywords “Probiotics” AND “Oral health” search databases PubMed, Scopus, Web Science. The was restricted English-language papers published from 1 January 2019 13 April 2023. Results: A total 3460 articles were found through our computerized search. After removing duplicates, reviewing papers, determining their relevance, 12 selected inclusion. Conclusions: Assessing how bacteria food or dietary supplements alter stable microbiota a complex task. Although probiotic microorganisms been proven therapeutic benefits, application health yet solidly backed by evidence. Further research necessary thoroughly understand long-term effects environment, including ability colonize form biofilms.

Language: Английский

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Artificial Intelligence and Its Clinical Applications in Orthodontics: A Systematic Review

Diagnostics, Journal Year: 2023, Volume and Issue: 13(24), P. 3677 - 3677

Published: Dec. 15, 2023

This review aims to analyze different strategies that make use of artificial intelligence enhance diagnosis, treatment planning, and monitoring in orthodontics. Orthodontics has seen significant technological advancements with the introduction digital equipment, including cone beam computed tomography, intraoral scanners, software coupled these devices. The deep learning sped up image processing processes. Deep is an technology trains computers data like human brain does. models are capable recognizing complex patterns photos, text, audio, other generate accurate information predictions.Pubmed, Scopus, Web Science were used discover publications from 1 January 2013 18 October 2023 matched our topic. A comparison various applications orthodontics was generated.A final number 33 studies included for qualitative analysis.These demonstrate effectiveness AI enhancing orthodontic assessment. lot articles emphasize integration into its potential revolutionize monitoring, evaluation, patient outcomes.

Language: Английский

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Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

Food & Function, Journal Year: 2023, Volume and Issue: 14(16), P. 7705 - 7717

Published: Jan. 1, 2023

CA supplementation could enhance intestinal integrity and barrier function by modifying microbiota its metabolites, which lead to a reduction in inflammatory responses oxidative stress LPS-challenged piglets.

Language: Английский

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Therapeutic Strategies and Genetic Implications for Periodontal Disease Management: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7217 - 7217

Published: June 29, 2024

The objective of this review is to identify the microbiological alterations caused by various therapy modalities critically analyzing current findings. We limited our search English-language papers published between 1 January 2004 and 7 May 2024 in PubMed, Scopus, Web Science that were relevant topic. In approach, Boolean keywords "microbio*" AND "periodontitis" used. A total 5152 obtained from databases (2205), PubMed (1793), Scopus (1154). This resulted 3266 articles after eliminating duplicates (1886), 1411 entries eliminated their titles abstracts examined. qualitative analysis 22 final included study. Research on periodontal disease shows periodontitis alters oral microbiome increases antibiotic resistance. Treatments like scaling root planing (SRP), especially when combined with minocycline, improve clinical outcomes reducing harmful bacteria. Comprehensive mechanical debridement antibiotics, probiotics, EMD bone grafts, other adjunctive therapies enhances health. Personalized treatment strategies advanced microbial analyses are crucial for effective management resistance control.

Language: Английский

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The interaction between gut microbiome and bone health

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2024, Volume and Issue: 31(3), P. 122 - 130

Published: April 8, 2024

This review critically examines interconnected health domains like gut microbiome, bone health, interleukins, chronic periodontitis, and coronavirus disease 2019 (COVID-19), offering insights into fundamental mechanisms clinical implications, contributing significantly to healthcare biomedical research.

Language: Английский

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Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5397 - 5418

Published: June 1, 2024

Background: The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened new way for efficient due burning or other injuries. Methods: This study aims develop characterize collagen-decorated, bilayered electrospun nanofibrous mats composed PVP PVA loaded with Resveratrol (RSV) Ampicillin (AMP) accelerate wound repair. Results: Nanofibers smooth surfaces web-like structures diameters ranging from 200 400 nm were successfully produced by electrospinning. These fibres exhibited excellent vitro properties, ability absorb exudates undergo biodegradation over two-week period. Additionally, these nanofibers demonstrated sustained controlled release encapsulated through studies. zone inhibition (ZOI) PVP-PVA-RSV-AMP against Staphylococcus aureus ( S. aureus) Escherichia coli E. ) was found 31± 0.09 mm 12± 0.03, respectively, which significantly higher as compared positive control. Similarly, biofilm confirmed significant reduction formation biofilms nanofiber-treated group both . X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR) analysis proved encapsulation RSV AMP into their compatibility. Haemolysis assay (%) showed no haemolysis (less than 5%) groups, cytocompatibility red blood cells (RBCs). Cell viability cell adhesion on HaCaT increased indicating its biocompatibility well non-toxic properties. Results in-vivo experiments model potential rats H&E-stained images also improved collagen synthesis nanofibers-treated groups evidenced Masson-trichrome staining. ELISA clearly indicated downregulation TNF-alpha IL-6 inflammatory biomarkers after treatment day 10. Conclusion: AMP-loaded nanofiber mats, developed this study, expedite multifaceted approach. Keywords: electrospinning, nanofiber, resveratrol, ampicillin, healing,

Language: Английский

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The Role of Curcumin in Oral Health and Diseases: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 660 - 660

Published: May 28, 2024

Curcumin (Curcumin) belongs to the polyphenol family. It is extracted by drying root of a plant Asian origin, belonging Zingiberaceae The best-known species Curcumincuma Longa. has been recognized as having great therapeutic powers since ancient times. Studies on curcumin have confirmed its powerful antioxidant properties, preventing both formation free radicals and their neutralization, anti-inflammatory, antibacterial, immunological, neuroprotective well being regulator intestinal microbiota with beneficial effects clinical manifestations metabolic syndrome. Our study aimed highlight how all these aspects could benefit oral health, improving course pathological processes. effect mouthwashes, curcumin-based gels regulation bacterial plaque in control gingivitis, was largely comparable that using 0.20% chlorhexidine, fewer side effects. Being highly hydrophobic substance, it high permeability cross cell membrane. Bioavailability increases when combined liposoluble substances (e.g., olive oil) piperine, which improves absorption. also negligible degree toxicity, making an excellent alternative use gold standard products for disinfection.

Language: Английский

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