Protection against Microglia Senescence by the Dietary Supplement Dekosilhue® in BV2 Cells: A New Perspective for Obesity and Related Complications DOI Creative Commons
Vittoria Borgonetti, Chiara Sasia, Martina Morozzi

et al.

Nutraceuticals, Journal Year: 2023, Volume and Issue: 3(2), P. 250 - 261

Published: May 23, 2023

Growing evidence indicates chronic low-grade systemic inflammation as a major pathophysiological mechanism of obesity. Systemic provokes an immune response in the brain through activation microglia that results development neuroinflammation, cellular senescence, and occurrence neurological dysfunction. In efforts to identify innovative intervention with potential efficacy on obesity associated complications, our aim was study capability dietary supplement Dekosilhue® (DKS), successfully used for improving control body weight, attenuate senescent phenotype. Microglia senescence induced by intermittent stimulation BV2 cells LPS 500 ng/mL every 72 h 4 h/day, over period 10 days. DKS (100 µg/mL) treatment reduced ß-galactosidase activity expression, formation senescence-associated heterochromatin foci levels, increased cell viability (2 folds control). DSK expression Nuclear Factor-kB (NF-kB) (20% lower than control), key molecule involved acquisition secretory phenotype (SASP). promoted neuroprotective effect increasing SH-SY5Y neuronal exposed conditioned medium values non-senescent cells. conclusion, attenuated phenotype, showing senotherapeutic might be further investigated adjunctive obesity-related disturbances.

Language: Английский

Obesity-induced inflammation: connecting the periphery to the brain DOI
Ophélia Le Thuc, Cristina García‐Cáceres

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(7), P. 1237 - 1252

Published: July 12, 2024

Language: Английский

Citations

22
Childhood Obesity, Hypothalamic Inflammation, and the Onset of Puberty: A Narrative Review DOI Open Access
Anastasia-Maria Tzounakou,

Galateia Stathori,

George Paltoglou

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1720 - 1720

Published: May 31, 2024

The onset of puberty, which is under the control hypothalamic–pituitary–gonadal (HPG) axis, influenced by various factors, including obesity, has been associated with earlier puberty. Obesity-induced hypothalamic inflammation may cause premature activation gonadotropin-releasing hormone (GnRH) neurons, resulting in development precocious or early Mechanisms involving phoenixin action and microglial cells are implicated. Furthermore, obesity induces structural cellular brain alterations, disrupting metabolic regulation. Imaging studies reveal neuroinflammatory changes obese individuals, impacting pubertal timing. Magnetic resonance spectroscopy enables assessment brain’s neurochemical composition measuring key metabolites, highlighting potential pathways involved neurological obesity. In this article, we present evidence indicating a association among inflammation,

Language: Английский

Citations

6
Quantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity DOI Creative Commons

Louise Baynat,

Takayuki Yamamoto, Thomas Tourdias

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(7), P. 1850 - 1857

Published: Jan. 9, 2024

Abstract Context Obesity is accompanied by damages to several tissues, including the brain. Pathological data and animal models have demonstrated an increased inflammatory reaction in hypothalamus hippocampus. Objective We tested whether we could observe such pathological modifications vivo through quantitative magnetic resonance imaging (MRI) metrics. Methods This prospective study was conducted between May 2019 November 2022. The Specialized Center for Care of a French University Hospital. Twenty-seven patients with obesity 23 age gender-paired normal-weight controls were prospectively recruited. All participants examined using brain MRI. Anthropometric biological data, eating behavior, anxiety, depression, memory performance assessed both groups. main outcome measure MRI following parametric maps: susceptibility mapping (QSM), mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio map, T2 relaxivity map. Results In hypothalamus, had higher FA lower QSM than controls. hippocampus, MD. There no correlation biomarkers behavior or anxiety. Conclusion Our findings are consistent presence neuroinflammation regions involved food intake. from appear provide incremental information assessment obesity.

Language: Английский

Citations

4
Microbiota-induced inflammation mediates the impacts of a Western diet on hippocampal-dependent memory DOI

Eden Crain,

Dulce M. Minaya, Claire B. de La Serre

et al.

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Neural correlates of the revised reinforcement sensitivity theory: A cross‐sectional structural neuroimaging study in middle‐aged adults DOI Creative Commons
Daniela A. Espinoza Oyarce, Richard A. Burns, Marnie Shaw

et al.

Psychophysiology, Journal Year: 2024, Volume and Issue: 61(8)

Published: March 28, 2024

Abstract The revised reinforcement sensitivity theory (RST) proposes that neurobiological systems control behavior: the fight‐flight‐freeze (FFFS) for avoidance of threat; behavioral approach/activation (BAS) approach to rewards; and inhibition (BIS) conflict resolution when are possible. Neuroimaging studies have confirmed some theoretical associations between brain structures BAS BIS; however, little representative population data available FFFS. We investigated neural correlates RST in a sample 404 middle‐aged adults ( M age = 47.18 SD 1.38); 54.5% female). Participants underwent structural magnetic resonance imaging completed health questionnaires BIS/BAS/FFFS scales. used multiple regression analyses investigate association scale scores volumes priori theoretically linked regions interest while controlling sex, age, intracranial volume, cardio‐metabolic variables; conducted exploratory on cortical thickness. BIS was negatively associated with hippocampus laterality. At standard significance levels, fear component FFFS positively anterior cingulate cortex; bilateral caudate; posterior cortex volume. Furthermore, these showed distinct patterns thickness though future work is needed. Our results characterized rodents can also be identified human brain.

Language: Английский

Citations

3
Obesity-induced chronic low-grade inflammation in adipose tissue: A pathway to Alzheimer’s disease DOI Creative Commons

Zhai Weijie,

Zhao Meng,

Wei Chunxiao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102402 - 102402

Published: July 6, 2024

Alzheimer's disease (AD) is a leading cause of cognitive impairment worldwide. Overweight and obesity are strongly associated with comorbidities, such as hypertension, diabetes, insulin resistance (IR), which contribute substantially to the development AD subsequent morbidity mortality. Adipose tissue (AT) highly dynamic organ composed diverse array cell types, can be classified based on their anatomic localization or cellular composition. The expansion remodeling AT in context involves immunometabolic functional shifts steered by intertwined actions multiple immune cells cytokine signaling within AT, metabolic disorders, IR, systemic markers chronic low-grade inflammation. Chronic inflammation, prolonged, low-dose stimulation specific immunogens that progress from localized sites affect organs throughout body, leads neurodystrophy, increased apoptosis, disruption homeostasis, manifesting brain atrophy AD-related pathology. In this review, we sought elucidate mechanisms contributes onset progression through mediation particularly focusing roles adipokines AT-resident cells.

Language: Английский

Citations

3
Calorie restriction mitigates metabolic, behavioral and neurochemical effects of cafeteria diet in aged male rats DOI
Jeferson Jantsch, Fernanda da Silva Rodrigues, Gabriel de Farias Fraga

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 119, P. 109371 - 109371

Published: May 10, 2023

Language: Английский

Citations

8
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study DOI
René Labounek,

Monica T. Bondy,

Amy Paulson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population 267 healthy human adults (age 30.1±6.6 years old, 125 females). We show correlated strongly moderately gray matter (GM) volume, cortical GM total cerebellar brainstem cross-sectional area (CSA) cervical SC white (CSA-WM; 0.44≤r≤0.62). In comparison, age weakly precentral thickness (-0.21≥r≥-0.27). Body weight magnetization transfer ratio WM, dorsal columns, lateral corticospinal tracts (-0.20≥r≥-0.23). further mean diffusivity diffusion tensor (DTI) WM (r=-0.20) columns (-0.21), but only males. CSA-WM volumes (0.39≤r≤0.64), gyrus DTI-based fractional anisotropy (-0.22≥r≥-0.25). Linear mixture explained 26±10% data variance volumetry CSA. The amount increased at 33±11% when was added into model. Age itself 2±2% variance. conclusion, is significant variable. Along age, should therefore be included mandatory variable design studies examining structure.

Language: Английский

Citations

2
Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation DOI Open Access
Antonio Rivas-Domínguez,

Himan Mohamed-Mohamed,

Margarita Jiménez-Palomares

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8042 - 8042

Published: April 28, 2023

Aging continues to be the main cause of development Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence progress dementia, including obesity and hyperlipidemia. In this sense, previous studies have shown a relationship between low-density lipoprotein receptor (LDLR) amyloid-beta (Aβ) binding activity, one neuropathological features Alzheimer’s disease (AD). LDLR is involved in several processes, lipid transport, regulation response metabolism. From perspective, LDLR−/− mice are widely accepted animal model for study associated with alterations metabolism, such as familial hypercholesterolemia, cardiovascular diseases, metabolic syndrome, or early cognitive decline. context, we induced hyperlipidemia after feeding high-saturated fatty acid diet (HFD) 44 weeks. LDLR−/−-HFD exhibited obesity, hypertriglyceridemia, higher glucose levels, hepatic steatosis. addition, HFD increased plasmatic APOE ubiquitin 60S levels. These proteins related neuronal integrity health maintenance. agreement, detected mild dysfunctions fed HFD, whereas showed more severe evident affectation. Our data suggest central nervous system dysfunction well-established syndrome. As late consequence, syndrome boots many behavioral pathological recognized supporting control parameters could improve preservation prognosis.

Language: Английский

Citations

4
Association between patients with migraine and sarcopenia: A retrospective study DOI Creative Commons
Dong Ah Lee, Ho‐Joon Lee, Jinseung Kim

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(28), P. e38941 - e38941

Published: July 12, 2024

Recently, interest in sarcopenia has been increasing patients with various neurological diseases. Thus, we investigated the presence of episodic migraine (EM) based on temporal muscle thickness (TMT). This was a retrospectively observational study following STROBE guidelines. We enrolled EM and healthy controls. Both groups underwent brain magnetic resonance imaging, including three-dimensional T1-weighted imaging. calculated TMT using which is marker for sarcopenia. compared between controls, analyzed it according to aura. 82 53 not different controls (10.804 ± 2.045 mm vs 10.721 1.547 P = .801). Furthermore, aura (10.994 2.016 10.716 2.071 those without, .569). There were no correlations clinical characteristics EM, age, age onset, duration migraine, headache intensity, frequency. found statistical difference or without These findings suggest that there evidence EM.

Language: Английский

Citations

1