Life, Journal Year: 2023, Volume and Issue: 13(1), P. 148 - 148
Published: Jan. 4, 2023
Urinary tract infections (UTIs) represent one of the most common that are frequently encountered in health care facilities. One main mechanisms used by bacteria allows them to survive hostile environments is biofilm formation. Biofilms closed bacterial communities offer protection and safe hiding, allowing evade host defenses hide from reach antibiotics. Inside communities, show an increased rate horizontal gene transfer exchange resistance virulence genes. Additionally, communication within orchestrate expression genes, which further cements infestation increases invasiveness infection. These facts stress necessity continuously updating our information understanding etiology, pathogenesis, eradication methods this growing public concern. This review seeks understand role formation recurrent urinary tact outlining underlying different uropathogens, addition shedding light on some strategies.
Language: Английский
Citations
64Biofilm-mediated infections by multidrug-resistant microbes: a comprehensive exploration and forward perspectives
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)
Published: Feb. 14, 2024
Abstract A biofilm is a collection of microorganisms organized in matrix extracellular polymeric material. Biofilms consist microbial cells that attach to both surfaces and each other, whether they are living or non-living. These biofilms can lead hospital-acquired infections generally detrimental. They possess the ability resist human immune system antibiotics. The National Institute Health (NIH) states formation associated with 65% all illnesses 80% chronic illnesses. Additionally, non-device-related include conditions like cystic fibrosis, otitis media, infective endocarditis, inflammatory disorders. This review aims provide an overview research on caused by biofilms, methods used for detection, recent approaches combat future perspectives, including development innovative antimicrobial strategies such as peptides, bacteriophages, agents disrupt biofilms.
Language: Английский
Citations
27Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate
Biology, Journal Year: 2023, Volume and Issue: 12(4), P. 504 - 504
Published: March 26, 2023
Protecting food from bacterial contamination is crucial for ensuring its safety and avoiding foodborne illness. Serratia marcescens one of the contaminants that can form biofilms pigments spoil product could cause infections illness to consumer. Food preservation essential diminish such or at least reduce their pathogenesis; however, it should not affect odor, taste, consistency must be safe. Sodium citrate a well-known safe additive current study aims evaluate anti-virulence anti-biofilm activity low concentrations against S. marcescens. The antibiofilm activities sodium were evaluated phenotypically genotypically. results showed significant effect on decreasing biofilm formation other virulence factors, as motility production prodigiosin, protease, hemolysins. This owed downregulating virulence-encoding genes. An in vivo investigation was conducted mice histopathological examination isolated tissues liver kidney confirmed citrate. In addition, an silico docking binding ability quorum sensing (QS) receptors regulates virulence. marked virtual compete QS proteins, which explain citrate's effect. conclusion, used prevent by bacteria.
Language: Английский
Citations
30Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria
Applied Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 107(11), P. 3763 - 3778
Published: April 20, 2023
Language: Английский
Citations
29What’s old is new again: Insights into diabetic foot microbiome
World Journal of Diabetes, Journal Year: 2023, Volume and Issue: 14(6), P. 680 - 704
Published: June 14, 2023
Diabetes is a chronic disease that considered one of the most stubborn global health problems continues to defy efforts scientists and physicians. The prevalence diabetes in population grow alarming levels year after year, causing an increase incidence complications care costs all over world. One major complication high susceptibility infections especially lower limbs due immunocompromised state diabetic patients, which definitive factor cases. Diabetic foot continue be common patients are associated with risk serious such as bone infection, limb amputations, life-threatening systemic infections. In this review, we discussed circumstances infection well some commonly isolated pathogens from related virulence behavior. addition, shed light on different treatment strategies aim at eradicating infection.
Language: Английский
Citations
27Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems
Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1442 - 1442
Published: May 14, 2023
The repurposing of drugs is one the most competent strategies for discovering new antimicrobial agents. Vildagliptin a dipeptidyl peptidase-4 inhibitor (DPI-4) that used effectively in combination with metformin to control blood glucose levels diabetic patients. This study was designed evaluate anti-virulence activities this against clinically important pathogens, Pseudomonas aeruginosa. current findings show significant ability vildagliptin-metformin diminish biofilm formation, bacterial motility, and production virulent extracellular enzymes pyocyanin pigment. Furthermore, drug significantly increased susceptibility P. aeruginosa oxidative stress, indicating immunity enhancement eradication cells. In compliance vitro findings, histopathological photomicrographs mice showed considerable protective effect metformin-vildagliptin aeruginosa, revealing relief inflammation due aeruginosa-induced pathogenesis. mainly employs quorum sensing (QS) systems its huge arsenal virulence factors. can be interrupted by anti-QS both vildagliptin, as exhibited affinity QS receptors. Additionally, downregulated expression main three QS-encoding genes These at very low concentrations (10, 1.25 mg/mL, respectively) compared (850, 50 diabetes.
Language: Английский
Citations
25Assessing the antibacterial potential of 6-gingerol: Combined experimental and computational approaches
Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(5), P. 102041 - 102041
Published: March 18, 2024
The rise of antibiotic resistance in bacteria is becoming a global concern, particularly due to the dwindling supply new antibiotics. This situation mandates discovery antimicrobial candidates. Plant-derived natural compounds have historically played crucial role development antibiotics, serving as rich source substances possessing properties. Numerous studies supported reputation 6-gingerol, prominent compound found ginger family, for its antibacterial In this study, activities 6-gingerol were evaluated against Gram-negative bacteria, Acinetobacter baumannii and Klebsiella pneumoniae, with particular focus on clinically significant Pseudomonas aeruginosa Gram-positive Staphylococcus aureus. Furthermore, anti-virulence assessed vitro, vivo, silico. current findings showed that 6-gingerol's activity effect disruption bacterial cell membrane efflux pumps, it significantly decreased disrupted S. aureus P. aeruginosa. biofilm formation production virulence factors concentrations below MICs. properties could be attributed capacity disrupt virulence-regulating systems; quorum sensing (QS). 6-Gingerol was interact QS receptors downregulate genes responsible QS. addition, molecular docking, dynamics (MD) simulation results indicated comparable binding affinity co-crystalized ligands different targets well stable interactions during 100 ns MD simulations. These suggest holds promise an agent can combined antibiotics treatment severe infections.
Language: Английский
Citations
13Overview of Proteus mirabilis pathogenicity and virulence. Insights into the role of metals
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 5, 2024
Proteus mirabilis is a Gram-negative bacterium with exclusive molecular and biological features. It versatile pathogen acclaimed for its distinct urease production, swarming behavior, rapid multicellular activity. Clinically, P. frequent of the human urinary system where it causes tract infections (UTIs) catheter-associated (CAUTIs). This review explores epidemiology, risk factors, clinical manifestations, treatment infections, emphasizing association UTIs. The bacterium’s genome analysis revealed presence resistance genes against commonly used antibiotics, an antibiotic-resistant phenotype that poses serious challenge. Particularly, emergence extended-spectrum β-lactamases (ESBLs) carbapenemases resistant strains. On level, possesses wide array virulence factors including production fimbriae, urease, hemolysins, metallophores, biofilm formation. thoroughly tackles substantial gap in understanding role metallophores shaping virulence. Siderophores, iron metal chelating transporting particularly contribute to complex pathogenic strategies, displaying potential target therapeutic intervention.
Language: Английский
Citations
12Utilization of zein nano-based system for promoting antibiofilm and anti-virulence activities of curcumin against Pseudomonas aeruginosa
Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)
Published: Jan. 1, 2024
Abstract Bacterial biofilms contribute to increased pathogenesis and bacterial resistance. Biofilms can enhance pathogenicity by shielding bacteria from the immune system antibiotics, they are associated with persistent infections. Additionally, antibiotic resistance mechanisms within make them challenging treat, emphasizing need for strategies be addressed. Mitigating virulence is a promising strategy that could ease their eradication host immunity without stressing induce The merits of this augmented when using safe anti-virulence candidates in proper formulations. current study aimed evaluate antibiofilm efficacy curcumin–zein nanoparticles against Pseudomonas aeruginosa . In vitro investigations were performed assess effect on biofilm formation, motility, production factors, including proteases, hemolysins, pyocyanin, comparison bulk curcumin. Furthermore, expression genes encode quorum sensing (QS) systems regulate was assessed. An silico done affinity curcumin QS receptors. an vivo protection assay inhibitory our preparation diminishing P. aeruginosa’s capacity pathogenesis. results showed significant activities compared These attributed curcumin’s interfering its virulence. conclusion, acquires anti-QS, anti-virulence, vastly enhanced upon loading zein nanoparticles.
Language: Английский
Citations
11Unveiling the hidden language of bacteria: anti-quorum sensing strategies for gram-negative bacteria infection control
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)
Published: Feb. 27, 2024
Language: Английский
Citations
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