Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 15, 2024
As
a
newly
emerging
organ
transplantation
technique,
islet
has
shown
the
advantages
of
minimal
trauma
and
high
safety
since
it
was
first
carried
out.
The
proposal
Edmonton
protocol,
which
been
widely
applied,
breakthrough
in
this
method.
However,
direct
contact
between
islets
portal
vein
blood
will
cause
robust
innate
immune
response
leading
to
massive
apoptosis
graft,
macrophages
play
an
essential
role
response.
Therefore,
therapeutic
strategies
targeting
have
become
popular
research
topic
recent
years.
This
paper
summarize
analyze
on
for
regulating
immunity,
primarily
focusing
macrophages,
field
transplantation,
including
drug
therapy,
optimization
preparation
process,
engineering
Mesenchymal
stem
cells
cotransplantation.
We
also
expounded
heterogeneity,
plasticity
activation
mechanism
providing
theoretical
basis
further
research.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
8, P. 100537 - 100537
Published: June 21, 2024
Chitosan
is
a
natural
polysaccharide
that
has
earned
much
credit
in
the
pharmaceutical
field
due
to
its
broad
implementation
drugs,
antigens,
and
vaccine
delivery.
Owing
unique
characteristics
of
biocompatibility,
biodegradability,
mucoadhesiveness,
less
toxicity,
chitosan
holds
promise
as
adjuvant
or
delivery
system.
Furthermore,
exhibits
antiviral
properties
making
it
an
ideal
carrier
for
vaccine.
The
presence
ridiculous
functional
groups
parent
structure
enables
creation
modified
derivatives
having
improved
physiochemical
which
provide
enhanced
chitosan.
This
review
summarizes
potential
agent
along
with
patents
related
application
carrier.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Nov. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116842 - 116842
Published: May 28, 2024
With
advancements
in
nanotechnology
and
innovative
materials,
Graphene
Oxide
nanoparticles
(GONP)
have
attracted
lots
of
attention
among
the
diverse
types
nanomaterials
owing
to
their
distinctive
physicochemical
characteristics.
However,
usage
at
scientific
industrial
level
has
also
raised
concern
toxicological
interaction
with
biological
system.
Understanding
these
interactions
is
crucial
for
developing
guidelines
recommendations
applications
GONP
various
sectors,
like
biomedicine
environmental
technologies.
This
review
offers
insights
an
in-depth
analysis
processes
associated
immunotoxicity
multiple
cell
lines
including
human
whole
blood
cultures,
dendritic
cells,
macrophages,
cancer
lines.
The
complicated
between
graphene
oxide
immune
system,
are
highlighted
this
work,
which
reveals
a
range
immunotoxic
consequences
inflammation,
immunosuppression,
immunostimulation,
hypersensitivity,
autoimmunity,
cellular
malfunction.
Moreover,
effects
respect
vivo
models
mice
zebrafish,
insighting
GO
Nanoparticles'
cytotoxicity.
study
provides
invaluable
researchers,
policymakers,
industrialist
understand
exploit
beneficial
controlled
measure
health
environment.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(8), P. 225 - 225
Published: Aug. 14, 2024
The
intersection
of
immunology
and
nanotechnology
has
provided
significant
advancements
in
biomedical
research
clinical
applications
over
the
years.
Immunology
aims
to
understand
immune
system’s
defense
mechanisms
against
pathogens.
Nanotechnology
demonstrated
its
potential
manipulate
responses,
as
nanomaterials’
properties
can
be
modified
for
desired
application.
Research
shown
that
nanomaterials
applied
diagnostics,
therapy,
vaccine
development.
In
used
biosensor
development,
accurately
detecting
biomarkers
even
at
very
low
concentrations.
Therapeutically,
act
efficient
carriers
delivering
drugs,
antigens,
or
genetic
material
directly
targeted
cells
tissues.
This
delivery
improves
therapeutic
efficacy
reduces
adverse
effects
on
healthy
nanoparticles
improve
durability
extend
responses
by
effectively
adjuvants
antigens
cells.
Despite
these
advancements,
challenges
regarding
safety,
biocompatibility,
scalability
are
still
present.
review
will
cover
fundamental
interactions
between
system,
their
immunology,
safety
biocompatibility
concerns.
BioFactors,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 28, 2024
Abstract
Anticancer
drug
discovery
needs
serious
attention
to
overcome
the
high
mortality
rate
caused
by
cancer.
There
are
still
many
obstacles
treating
this
disease,
such
as
cost
of
chemotherapeutic
drugs,
resulting
side
effects
from
drug,
and
occurrence
multidrug
resistance.
Herbaceous
plants
a
reservoir
natural
compounds
that
can
be
anticancer
drugs
with
novel
mechanisms
action.
Piperine,
bioactive
compound
derived
Piper
species,
is
gaining
due
its
unique
dual
role
in
directly
inhibiting
tumor
growth
enhancing
bioavailability
drugs.
Unlike
conventional
treatments,
Piperine
exhibits
mechanism
action
modulating
multiple
signaling
pathways,
including
apoptosis
autophagy,
low
toxicity.
Additionally,
acts
bioenhancer
improving
absorption
effectiveness
other
agents,
reducing
required
dosage,
minimizing
effects.
Therefore,
review
aims
visualize
summary
sources,
phytochemistry,
chemical
structure–anticancer
activity
relationship,
activities
semi‐synthetic
derivatives,
pharmacokinetic
bioavailability,
vitro
vivo
preclinical
studies,
antitumor
action,
human
clinical
trials,
toxicity,
effects,
safety
Piperine.
References
were
collected
Pubmed/MedLine
database
(
https://pubmed.ncbi.nlm.nih.gov/
)
following
keywords:
“Piperine
anticancer,”
derivatives,”
mechanism”
bioavailability,”
after
filter
process
inclusion
exclusion
criteria,
101
selected
444
articles.
From
2013
2023,
there
numerous
studies
regarding
various
cell
lines,
breast
cancer,
prostate
lung
melanoma,
cervical
gastric
osteosarcoma,
colon
hepatocellular
carcinoma,
ovarian
leukemia,
colorectal
hypopharyngeal
carcinoma.
In
vivo,
study
has
also
been
conducted
on
some
animal
models,
Ehrlich
carcinoma‐bearing
mice,
ascites
carcinoma
cells‐bearing
Balbc
Wistar
rat,
A375SM
A375P
SNU‐16
BalbC
HGC‐27‐bearing
baby
mice.
Treatment
leads
proliferation
inhibition
induction
apoptosis.
used
for
trials
diseases,
but
no
cancer
patient
report
exists.
Various
derivatives
show
efficacy
an
across
lines.
shows
promise
use
either
standalone
treatment
or
bioenhancer.
Its
properties
may
enhance
existing
providing
valuable
foundation
developing
new
therapies.
Environmental Toxicology and Pharmacology,
Journal Year:
2023,
Volume and Issue:
104, P. 104298 - 104298
Published: Oct. 19, 2023
The
crescent
presence
of
nanoplastics
in
the
environment
raises
concerns
regarding
their
potential
impact
on
health.
This
study
exposed
human
colon
adenocarcinoma
cells
(HT29)
and
microglia
(N9)
to
(25
nm,
50
100
nm
Polystyrene)
investigate
inflammatory
responses,
which
are
vital
for
body's
defence.
Although
cytotoxicity
remained
generally
low,
HT29
exhibited
a
notable
upregulation
p50
p38
expression,
concomitant
with
elevated
TLR4
contrast
N9
that
showed
less
pronounced
these
proteins.
Additionally,
nanoplastic
exposure
increased
IL-1ß
levels,
partially
attenuated
by
pre-exposure
or
inhibitors.
Intriguingly,
substantial
increases
iNOS
mRNA.
effect
was
entirely
prevented
inhibitors,
while
TNF-α
mRNA
levels
relatively
stable.
These
findings
underscore
activate
pathways,
response
kinetics
varying
depending
cell
type.
Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 19, 2023
Abstract
Bone
infection
poses
a
major
clinical
challenge
that
can
hinder
patient
recovery
and
exacerbate
postoperative
complications.
This
study
has
developed
bioactive
composite
scaffold
through
the
co‐assembly
intrafibrillar
mineralization
of
collagen
fibrils
zinc
oxide
(ZnO)
nanowires
(IMC/ZnO).
The
IMC/ZnO
exhibits
bone‐like
hierarchical
structures
enhances
capabilities
for
osteogenesis,
antibacterial
activity,
bacteria‐infected
bone
healing.
During
co‐cultivation
with
human
marrow
mesenchymal
stem
cells
(BMMSCs),
improves
BMMSC
adhesion,
proliferation,
osteogenic
differentiation
even
under
inflammatory
conditions.
Moreover,
it
suppresses
activity
Gram‐negative
Porphyromonas
gingivalis
Gram‐positive
Streptococcus
mutans
by
releasing
ions
within
acidic
infectious
microenvironment.
In
vivo,
enables
near‐complete
healing
infected
defects
intricate
oral
bacterial
milieu,
which
is
attributed
to
orchestrating
M2
macrophage
polarization,
fostering
an
anti‐inflammatory
Overall,
these
findings
demonstrate
promise
treating
defects.
