Current Cancer Drug Targets, Journal Year: 2023, Volume and Issue: 24(3), P. 288 - 307
Published: July 13, 2023
This review describes the comprehensive portrait of tumor microenvironment (TME). Additionally, we provided a panoramic perspective on transformation and functions diverse constituents in TME, underlying mechanisms drug resistance, beginning with immune cells metabolic dynamics within TME. Lastly, summarized most auspicious potential therapeutic strategies.
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 743 - 743
Published: March 27, 2024
Mesenchymal stem cells (MSCs) have been recognized as a cell therapy with the potential to promote skin healing. MSCs, their multipotent differentiation ability, can generate various related wound healing, such dermal fibroblasts (DFs), endothelial cells, and keratinocytes. In addition, MSCs neovascularization, cellular regeneration, tissue healing through mechanisms including paracrine autocrine signaling. Due these characteristics, extensively studied in context of burn chronic repair. Furthermore, during investigation unique roles aging scarless also discovered. this review, we summarize by which discuss recent findings from preclinical clinical studies. We explore strategies enhance therapeutic effects MSCs. Moreover, emerging trend combining engineering techniques, leveraging advantages materials, biodegradable scaffolds hydrogels, repair capacity Additionally, highlight using characteristics cell-free therapies future direction cell-based treatments, further demonstrating regenerative aesthetic applications regeneration.
Language: Английский
Citations
23
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 13, 2025
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential
Language: Английский
Citations
9
Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 382 - 382
Published: Jan. 24, 2025
Cancer stem cells (CSCs) play a central role in tumor progression, recurrence, and resistance to conventional therapies, making them critical focus oncology research. This review provides comprehensive analysis of CSC biology, emphasizing their self-renewal, differentiation, dynamic interactions with the microenvironment (TME). Key signaling pathways, including Wnt, Notch, Hedgehog, are discussed detail highlight potential as therapeutic targets. Current methodologies for isolating CSCs critically examined, addressing advantages limitations advancing precision medicine. Emerging technologies, such CRISPR/Cas9 single-cell sequencing, explored transformative unraveling heterogeneity informing strategies. The also underscores pivotal TME supporting survival, promoting metastasis, contributing resistance. Challenges arising from CSC-driven dormancy analyzed, along strategies mitigate these barriers, novel therapeutics targeted approaches. Ethical considerations integration artificial intelligence designing CSC-specific therapies essential elements future manuscript advocates multi-disciplinary approach that combines innovative advanced therapeutics, collaborative research address complexities CSCs. By bridging existing gaps knowledge fostering advancements personalized medicine, this aims guide development more effective cancer treatment strategies, ultimately improving patient outcomes.
Language: Английский
Citations
1
Oncology Letters, Journal Year: 2025, Volume and Issue: 29(5), P. 1 - 17
Published: March 4, 2025
The expression of cytosolic aldehyde dehydrogenases (ALDHs), which mediate the last step in pathway synthesis all‑trans retinoic acid, is dysregulated various types human cancer, and has been associated with development cancer stem cells (CSCs) solid tumors hematological malignancies. CSCs are considered a minor fraction capacity to initiate neoplastic tumors. ALDH1A1 serves crucial role emergence CSC phenotype, induces malignant behavior promotes treatment resistance. Notably, ALDH1A1‑induced therapy resistance not exclusive just one group drugs, but affects diverse drugs that use different mechanisms kill cells. This diversity drug resistance‑inducing effects stemness‑supporting functions ALDH1A1. inhibition activity using chemicals or depletion via genetic approaches, such as small interfering RNA, can overcome pathways In context breast it critical only expected manifest stem‑like features, include increased From angle disease prognosis, extent association remains be determined through application cutting‑edge methods detect tracked biomarkers within
Language: Английский
Citations
1
Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1234 - 1234
Published: April 5, 2025
Background/Objectives: The significance of cytokine signaling on cancer progression and metastasis has raised interest in research over the last few decades. Here, we analyzed effects three cytokines that previously reported are significantly upregulated rapidly after surgical removal primary breast, colorectal, prostate cancer. We also investigated regulation their cognate receptors. Methods: All experiments were conducted using PANC-1, SW620, MCF-7 cell lines, treated with different (TGF-β1, HGF, IL-6). effect these expression epithelial-mesenchymal transition (EMT) surface markers neuraminidase-1 activity was measured via fluorescent microscopy image analysis software. Results: findings show increase mesenchymal while reducing epithelial markers, corresponding to EMT process. A strong link between receptor Neu-1-MMP-9-GPCR crosstalk identified, suggesting binding leads increased Neu-1 subsequent pathway activation. Oseltamivir phosphate (OP) prevented sialic acid hydrolysis by (Neu-1), leading downregulation cascades. Conclusions: In concert previous work revealing role regulating other glycosylated receptors implicated proliferation EMT, targeting may provide effective treatment against a variety malignancies. Most significantly, patients specific inhibitors soon surgery improve our ability cure early-stage inhibiting process disrupting any residual population metastasize.
Language: Английский
Citations
1
Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23
Published: Jan. 1, 2024
Colorectal cancer (CRC) is the third most frequently found in world, and it discovered when already far along its development. About 20% of cases CRC are metastatic incurable. There more evidence that colorectal stem cells (CCSCs), which charge tumor growth, recurrence, resistance to treatment, what make so different. Because we know about cell biology, quickly learned molecular processes possible cross-talk between signaling pathways affect balance gut cancer. Wnt, Notch, TGF-β, Hedgehog examples pathway members whose genes may change produce CCSCs. These control self-renewal pluripotency SCs then decide function phenotype However, terms their ability create tumors susceptibility chemotherapeutic drugs, CSCs differ from normal bulk cells. This be reason for higher rate recurrence patients who underwent both surgery chemotherapy treatment. Scientists have a group uncontrolled miRNAs related CCSCs stemness properties. CCSC functions like changing expression cycle genes, metastasis, drug mechanisms. CCSC-related mostly signal known important biology. The biomarkers (CD markers miRNA) diagnostic roles main topics this review study.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7470 - 7470
Published: July 8, 2024
Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU) resistance being major obstacle to effective treatment. Despite advancements, 5-FU remains formidable due complex mechanisms such as alterations in drug transport, evasion of apoptosis, dysregulation cell cycle dynamics, tumor microenvironment (TME) interactions, and extracellular vesicle (EV)-mediated pathways. Traditional chemotherapy often results high toxicity, highlighting the need for alternative approaches better efficacy safety. Phytochemicals (PCs) EVs offer promising CRC therapeutic strategies. PCs, derived from natural sources, exhibit lower toxicity can target multiple pathways involved progression resistance. facilitate targeted delivery, modulate immune response, interact TME sensitize cells However, potential PCs engineered overcoming reshaping immunosuppressive underexplored. Addressing this gap crucial identifying innovative therapies enhanced reduced toxicities. This review explores multifaceted evaluates synergistic effects combining improve treatment while minimizing adverse effects. Additionally, it investigates by serving delivery vehicles modulating TME. By synthesizing current knowledge addressing research gaps, enhances academic understanding CRC, interdisciplinary involving revolutionizing therapy. Further clinical validation are essential translating these findings into improved patient outcomes.
Language: Английский
Citations
6
Stem Cell Reviews and Reports, Journal Year: 2023, Volume and Issue: 19(7), P. 2141 - 2154
Published: July 21, 2023
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8647 - 8647
Published: Aug. 8, 2024
Cancer stem cells represent a resilient subset within the tumor microenvironment capable of differentiation, regeneration, and resistance to chemotherapeutic agents, often using dormancy as shield. Their unique properties, including drug metastatic potential, pose challenges for effective targeting. These exploit certain metabolic processes their maintenance survival. One these is autophagy, which generally helps in energy homeostasis but when hijacked by CSCs can help maintain stemness. Thus, it referred an Achilles heel CSCs, cancers tend depend on autophagy Autophagy, while crucial maintaining stemness cancer (CSCs), also serve vulnerability contexts, making complex target therapy. Regulators like AMPK (5' adenosine monophosphate-activated protein kinase) play role helping reprogramming harsh environments. The purpose this review elucidate interplay between highlighting targeting discussing therapeutic strategies overcome limitations. This focuses previous research its regulators biology, particularly addresses remaining unanswered questions, potential targets therapy are brought attention.
Language: Английский
Citations
5