Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 539 - 539

Published: July 3, 2023

Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview recent advances application healing. synthesis methods, structural characteristics, properties are discussed. Mechanisms released from hydrogels, including diffusion, swelling, degradation, also analyzed. In addition, effects on healing, well reduction inflammation, antimicrobial activity, tissue regeneration, highlighted. incorporation various agents, such anti-inflammatory ones, into is reviewed detail. Furthermore, challenges future prospects dressing applications considered. This review valuable information current status highlights potential improve healing outcomes.

Language: Английский

---

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3849 - 3849

Published: March 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Language: Английский

---

Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Hydrogels, composed of hydrophilic polymer networks, have emerged as versatile materials in biomedical applications due to their high water content, biocompatibility, and tunable properties. They mimic natural tissue environments, enhancing cell viability function. Hydrogels' physical properties allow for tailored antibacterial biomaterial, wound dressings, cancer treatment, engineering scaffolds. Their ability respond physiological stimuli enables the controlled release therapeutics, while porous structure supports nutrient diffusion waste removal, fostering regeneration repair. In healing, hydrogels provide a moist environment, promote migration, deliver bioactive agents antibiotics, healing process. For therapy, they offer localized drug delivery systems that target tumors, minimizing systemic toxicity improving therapeutic efficacy. Ocular therapy benefits from hydrogels' capacity form contact lenses maintain prolonged with eye surface, treatment outcomes various diseases. mucosal delivery, facilitate administration therapeutics across barriers, ensuring sustained improved bioavailability drugs. Tissue sees scaffolds extracellular matrix, supporting growth differentiation repairing damaged tissues. Similarly, bone regeneration, loaded factors stem cells osteogenesis accelerate healing. This article highlights some recent advances use applications, driven by be engineered specific needs interactive biological

Language: Английский

---

Natural Regenerative Hydrogels for Wound Healing

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 547 - 547

Published: Aug. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Language: Английский

---

Natural products in the treatment of diabetic foot infection

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 7, 2025

Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.

Language: Английский

---

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2696 - 2696

Published: Sept. 8, 2023

Biomaterials are mostly any natural and synthetic materials which compatible from a biological point of view with the human body. widely used to sustain, increase, reestablish or substitute function injured tissue organ Additionally, biomaterials uninterruptedly in contact body, i.e., tissue, blood fluids. For this reason, an essential feature is their biocompatibility. Consequently, review summarizes classification different types based on origin, as ones. Moreover, advanced applications pharmaceutical medical domains highlighted specific mechanical physical properties biomaterials, concerning use. The high-priority challenges field also discussed, especially those regarding transfer implementation valuable scientific results practice.

Language: Английский

---

High-Content Aloe vera Based Hydrogels: Physicochemical and Pharmaceutical Properties

Polymers, Journal Year: 2023, Volume and Issue: 15(5), P. 1312 - 1312

Published: March 6, 2023

The present research focuses on the physicochemical and pharmacotechnical properties of new hydrogels obtained using allantoin, xanthan gum, salicylic acid different concentrations Aloe vera (5, 10, 20% w/v in solution; 38, 56, 71 wt% dry gels). thermal behavior composite was studied DSC TG/DTG analyses. chemical structure investigated characterization methods (XRD, FTIR Raman spectroscopies) morphology SEM AFM microscopy. Pharmacotechnical evaluation tensile strength elongation, moisture content, swelling spreadability also completed. Physical confirmed that appearance prepared based homogeneous color varied from pale beige to deep opaque with increasing concentration. All other parameters, e.g., pH, viscosity, consistency were found be adequate all hydrogel formulations. images show condensed into polymeric solids addition vera, accordance decrease peak intensities observed via XRD analysis. These results suggest interactions between matrix as Considering content higher than 10% (w/v) did not stimulate further interactions, this formulation (FA-10) can used for biomedical applications.

Language: Английский

---

Hydrogels with Essential Oils: Recent Advances in Designs and Applications

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 636 - 636

Published: Sept. 30, 2024

The innovative fusion of essential oils with hydrogel engineering offers an optimistic perspective for the design and development next-generation materials incorporating natural bioactive compounds. This review provides a comprehensive overview latest advances in use hydrogels containing biomedical, dental, cosmetic, food, food packaging, restoration cultural heritage applications. Polymeric sources, methods obtaining, cross-linking techniques, functional properties are discussed. unique characteristics polymer agents highlighted. These include biocompatibility, nontoxicity, effective antibacterial activity, control sustained prolonged release active substances, optimal porosity, outstanding cytocompatibility. Additionally, specific distinctive explored, along their extraction encapsulation methods. advantages disadvantages these also We have considered limitations due to volatility, solubility, environmental factors, stability. importance loading hydrogels, stability, biological activity is analyzed. highlights through in-depth analysis, recent innovations, challenges, future prospects encapsulated potential multiple applications including biomedicine, dentistry, cosmetics, conservation.

Language: Английский

---

Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

---

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2661 - 2661

Published: July 16, 2023

Transdermal delivery devices and wound dressing materials are constantly improved upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, cost effectiveness. Therefore, researchers in field have shown an increasing interest using natural compounds as constituents for such systems. Plants, important source so-called “natural products” enormous variety structural diversity that still exceeds capacity present-day sciences to define or even discover them, been part medicine since ancient times. However, benefits just at beginning being fully exploited modern dermal transdermal Thus, plant-based primary compounds, without biological activity, contained gums mucilages, traditionally used gelling texturing agents food industry, now explored valuable cost-effective components biomedical field. Their non-toxicity compensate local availability compositional variations. Also, secondary metabolites, classified based on chemical structure, intensively investigated wide pharmacological toxicological effects. impact is highlighted detail through most recent reported studies. Innovative isolation purification techniques, new drug systems, advanced evaluation procedures presented.

Language: Английский

---