Emerging Topics in Metal Complexes: Pharmacological Activity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4982 - 4982

Published: May 3, 2024

This Special Issue (SI), ”Emerging Topics in Metal Complexes: Pharmacological Activity”, includes reports updating our knowledge on metals with multidirectional biological properties and metal-containing compounds/complexes for their potential therapeutic applications, a focus strategies improving pharmacological features [...]

Language: Английский

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Vanadium(V) Pyridine‐Containing Schiff Base Catecholate Complexes are Lipophilic, Redox‐Active and Selectively Cytotoxic in Glioblastoma (T98G) Cells

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(68)

Published: Aug. 16, 2023

Two new series of complexes with pyridine-containing Schiff bases, [VV O(SALIEP)L] and O(Cl-SALIEP)L] (SALIEP=N-(salicylideneaminato)-2-(2-aminoethylpyridine; Cl-SALIEP=N-(5-chlorosalicylideneaminato)-2-(2-aminoethyl)pyridine, L=catecholato(2-) ligand) have been synthesized. Characterization by 1 H 51 V NMR UV-Vis spectroscopies confirmed that: 1) most form two major geometric isomers in solution, O(SALIEP)(DTB)] (DTB=3,5-di-tert-butylcatecholato(2-)) forms that equilibrate solution; 2) tert-butyl substituents were necessary to stabilize the reduced VIV species (EPR spectroscopy cyclic voltammetry). The pyridine moiety within base ligands significantly changed their chemical properties unsubstituted catecholate compared parent HSHED (N-(salicylideneaminato)-N'-(2-hydroxyethyl)-1,2-ethanediamine) complexes. Immediate reduction occurred for unsubstituted-catecholato VV on dissolution DMSO. By contrast, improved hydrolytic stability O(HSHED)(DTB)]. had moderate cell culture media. There was significant cellular uptake intact complex T98G (human glioblastoma) cells very good anti-proliferative activity (IC50 6.7±0.9 μM, 72 h), which approximately five times higher than non-cancerous human line, HFF-1 34±10 μM). This made a potential drug candidate treatment advanced gliomas intracranial injection.

Language: Английский

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Hydrazone-flavonol based oxidovanadium(V) complexes: Synthesis, characterization and antihyperglycemic activity of chloro derivative in vivo

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 258, P. 112637 - 112637

Published: June 6, 2024

Language: Английский

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Transition metal complexes: a new generation of anticancer drugs

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 16(17), P. 1727 - 1730

Published: Aug. 9, 2024

Language: Английский

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Ginseng fruit rare saponins (GFRS), a promising anti-wrinkle agent: Evidence of its antioxidant effect and its capacity to prevent matrix metalloproteinase (MMPs) expression in vitro and in vivo

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 215, P. 118716 - 118716

Published: May 11, 2024

Language: Английский

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Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Frontiers in Chemical Biology, Journal Year: 2024, Volume and Issue: 3

Published: July 5, 2024

Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand vanadium(V) Schiff base/catecholato complexes have exhibited high in vitro anti-proliferative activity. Hence, we explored the activity of [V V OL 1 L 2 ], which contains two iron chelating ligands, 2-hydroxy-1-naphthylaldehyde iso -nicotinoyhydrazone (L H ) and clioquinol H). This complex was previously reported be very effective against Trypanosoma cruzi , causative agent Chagas disease. These studies possibility that compound with efficacy also has human glioblastoma cells. Since ] poorly soluble water ligand dissociated from upon addition an aqueous environment, understanding speciation important interpret its biological Methods: Stability cell media were followed by UV/Vis spectroscopy determine relevance T98G cells, measured absence presence Fe(III). Results Discussion: The current work demonstrated vanadium coordination had (T98G) line. enhanced effects cells could due either hydrolysis release toxic clioquinol, or rapid uptake lipophilic prior hydrolysis. showed at least part potent toxicity stemmed bioactive complex, depended on whether Fe(III) present. (O) H)] most remained intact and, hence, active. Thus, future development should focus one-ligand making any more soluble, stable solution, designed rapidly taken up diseased

Language: Английский

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Unprecedented Organogermanium Functionalized Ge^IV−Sb^III‐Templating Polyoxotungstate Nanocluster for Photothermal–Chemodynamic Cancer Therapy

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: July 30, 2024

Abstract The function‐oriented synthesis of polyoxometalate (POM) nanoclusters has become an increasingly important area research. Herein, the well‐known broad‐spectrum anticancer drug Ge‐132 which contains Ge IV as potential heteroatoms and carboxyl coordination sites, is introduced to POM system, leading first organogermanium functionalized −Sb III ‐templating nanocluster Na 4 [H 2 N(CH 3 ) ] 16 H 18 [Sm (H O) 12 W O 14 Ge(CH CH COOH)] [SbW 9 33 [Ge(CH COOH) SbW 15 54 ·62H ( 1 ). An unprecedented templating Dawson‐like COOH)SbW 12− building block discovered. To take advantage pharmaceutical activity such organogermanium‐functionalized cluster, further composited with gold nanoparticles (NPs) prepare −Au NPs, doubles blood circulation time ‐based nanodrug. Efficient separation photogenerated charges in NPs largely boosts photothermal conversion efficiency (PCE = 55.0%), nearly 2.1 times that either single 26.7%) or Au 26.2%), simultaneously facilitate generation toxic activate reactive oxygen species tumor microenvironment. Based on these findings, it demonstrated are a multifunctional renal clearable nanomedicine great photoacoustic imaging guiding photothermal–chemodynamic therapy for breast cancer.

Language: Английский

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Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium(IV) complexes

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215271 - 215271

Published: June 7, 2023

Language: Английский

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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(3), P. 571 - 577

Published: July 20, 2023

Abstract Aging is a natural phenomenon characterized by progressive decline in physiological integrity, leading to deterioration of cognitive function and increasing the risk suffering from chronic-degenerative diseases, including cardiovascular osteoporosis, cancer, diabetes, neurodegeneration. considered major factor for Parkinson’s Alzheimer’s disease develops. Likewise, diabetes insulin resistance constitute additional factors developing neurodegenerative disorders. Currently, no treatment can effectively reverse these pathologies. However, some antidiabetic drugs have opened possibility being used against processes. In previous framework, Vanadium species demonstrated notable effect. Our research group evaluated polyoxidovanadates such as decavanadate metforminium-decavanadate with preventive corrective activity on neurodegeneration brain-specific areas rats metabolic syndrome. The results suggest that induce neuronal restoration mechanisms. This review aims describe therapeutic potential insulin-enhancer agents brain, constituting alternative aging diseases.

Language: Английский

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Substitution Kinetics, Albumin and Transferrin Affinities, and Hypoxia All Affect the Biological Activities of Anticancer Vanadium(V) Complexes

Inorganic Chemistry, Journal Year: 2023, Volume and Issue: 62(43), P. 17804 - 17817

Published: Oct. 20, 2023

Limited stability of most transition-metal complexes in biological media has hampered their medicinal applications but also created a potential for novel cancer treatments, such as intratumoral injections cytotoxic short-lived anticancer drugs. Two related V(V) complexes, [VO(Hshed)(dtb)] (1) and [VO(Hshed)(cat)] (2), where H2shed = N-(salicylideneaminato)-N'-(2-hydroxyethyl)-1,2-ethanediamine, H2dtb 3,5-di-tert-butylcatechol, H2cat 1,2-catechol, decomposed within minutes cell culture medium at 310 K (t1/2 43 9 s 1 2, respectively). Despite this, both showed high antiproliferative activities triple-negative human breast (MDA-MB-231) cells, the mechanisms were radically different. Complex formed noncovalent adducts with serum albumin, rapidly entered cells via passive diffusion, was nearly active short-term treatment (IC50 1.9 ± 0.2 μM 30 min) compared long-term 1.3 72 h). The activity decreased about 20-fold after its decomposition min K. 2 similar ≈ 12 h) fresh solutions inactive treatment. mainly due to reactions among products, free catechol, O2 medium. As result, less sensitive than that effects hypoxic conditions are characteristic solid tumors presence apo-transferrin acts scavenger V(V/IV) products blood serum. In summary, complex 1, not is suitable candidate further development an drug delivered injections. These results demonstrate importance fine-tuning ligand properties optimization metal complexes.

Language: Английский

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