Immunology Letters, Journal Year: 2025, Volume and Issue: 274, P. 106992 - 106992
Published: March 6, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 19, 2024
Metabolic disorders remain a major global health concern in the 21st century, with increasing incidence and prevalence. Mitochondria play critical role cellular energy production, calcium homeostasis, signal transduction, apoptosis. Under physiological conditions, mitochondrial transfer plays crucial tissue homeostasis development. Mitochondrial dysfunction has been implicated pathogenesis of metabolic disorders. Numerous studies have demonstrated that mitochondria can be transferred from stem cells to pathologically injured cells, leading functional restoration. Compared cell therapy, transplantation lower immunogenicity, making exogenous healthy promising therapeutic approach for treating diseases, particularly This review summarizes association between mitochondria, mechanisms transfer, potential We hope this provides novel insights into targeted therapy
Language: Английский
Citations
5
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(22), P. 12573 - 12660
Published: Nov. 13, 2024
Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled study these signaling in living systems across temporal and spatial scales. Over years there has been an explosion number fluorescent biosensors, as they become available for numerous targets, utilized spectral space, suited various imaging techniques. To guide users this extensive biosensor landscape, we discuss critical aspects proteins consideration development, smart tagging strategies, historical recent types, grouped by target, with a focus on design applications sensors systems.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1857 - 1857
Published: Feb. 3, 2024
Gynecologic tract melanoma is a malignant tumor with poor prognosis. Because of the low survival rate and lack standard treatment protocol related to this condition, investigation mechanisms underlying progression crucial achieve advancements in relevant gynecological surgery treatment. Mitochondrial transfer between adjacent cells microenvironment regulates progression. This study investigated effects endothelial mitochondria on growth activation specific signal transduction pathways following mitochondrial transplantation. Mitochondria were isolated from (ECs) transplanted into B16F10 cells, resulting upregulation proteins associated growth. Furthermore, enhanced antioxidation homeostasis mediated by Sirt1-PGC-1α-Nrf2-HO-1 pathway observed, along inhibition apoptotic protein caspase-3. Finally, transplantation promoted increased M2-type macrophages through Nrf2/HO-1-mediated xenograft animal model. In summary, introduction exogenous ECs growth, indicating role stromal modulating tumor's phenotype. These results provide valuable insights potential targets for
Language: Английский
Citations
4
Clinical & Experimental Metastasis, Journal Year: 2024, Volume and Issue: 41(5), P. 567 - 587
Published: March 15, 2024
Abstract As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well migration, fate decisions, many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function cancer cells has found renewed interest, from suggested potential clinical biomarkers mitochondria-targeting therapies. Here, we will focus on the effect movement breast progression. Mitochondria move both within cell, such localize areas high energetic need, between where stroma have been shown donate their via multiple methods including tunneling nanotubes. The donation seen increase aggressiveness chemoresistance which increased recent efforts uncover mechanisms transfer. metabolism energetics gaining attention targets, better understanding implications required developing effective, targeted therapeutics patients.
Language: Английский
Citations
4
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2065 - 2065
Published: April 2, 2024
This comprehensive review explores the dynamic relationship between sports, nutrition, and neurological health. Focusing on recent clinical advancements, it examines how physical activity dietary practices influence prevention, treatment, rehabilitation of various conditions. The highlights role neuroimaging in understanding these interactions, discusses emerging technologies neurotherapeutic interventions, evaluates efficacy sports nutritional strategies enhancing recovery. synthesis current knowledge aims to provide a deeper lifestyle factors can be integrated into improve outcomes.
Language: Английский
Citations
4
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 29, 2024
Multiple Sclerosis (MS) is a neurologic autoimmune disease whose exact pathophysiologic mechanisms remain to be elucidated. Recent studies have shown that the onset and progression of MS are associated with dysbiosis gut microbiota. Similarly, large body evidence suggests mitochondrial dysfunction may also significant impact on development MS. Endosymbiotic theory has found human mitochondria microbial in origin share similar biological characteristics Therefore, microbiota function crosstalk relevant However, relationship between not fully understood. by synthesizing previous literature, this paper focuses changes metabolite composition possible MS, provide new therapeutic approaches for prevention or reduction based crosstalk.
Language: Английский
Citations
4
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Aging is an inevitable and complex biological process involving multi-factorial mechanisms. Mitochondrial dysfunction a critical factor in the aging process, characterized by decline mitochondrial quality activity, leading to aging-related diseases. Therefore, mitochondria have become attractive target anti-aging therapies. Several senolytic drugs targeting antioxidant agents been used research past few years. However, these strategies may cause adverse effects with long-term medication. In this extensive review, we propose "mitochondrial transplantation," which transfers healthy from donor cells recipient replace damaged or dysfunctional mitochondria, as new alternative strategy for treating aging-associated introduce contemporary landscape of transplantation, then discuss intensely successful applications transplantation therapy diseases such neurodegenerative diseases, cardiovascular aging, reproductive highlighting its translational potential. Finally, summarize prospect challenges opportunities faces therapy.
Language: Английский
Citations
4
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103331 - 103331
Published: Aug. 29, 2024
Mitochondria, traditionally recognized as cellular 'powerhouses' due to their pivotal role in energy production, have emerged multifunctional organelles at the intersection of bioenergetics, metabolic signaling, and immunity. However, understanding exact contributions immunity inflammation is still developing. This review first introduces innovative concept intracellular immunity, emphasizing how mitochondria serve critical immune signaling hubs. They are instrumental recognizing responding pathogen danger signals, modulating responses. We also propose leading organelles, drawing parallels with broader system functions antigen presentation, regulation, response. Our comprehensive explores mitochondrial pathways, therapeutic potential managing chronic diseases, discusses cutting-edge methodologies for research. Targeting a broad readership both experts newcomers field, this sets forth new directions that could transform our integrated organelles.
Language: Английский
Citations
4
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113015 - 113015
Published: Sept. 1, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1192 - 1192
Published: Jan. 30, 2025
Mitochondria are important organelles for cell metabolism and tissue survival. Their cell-to-cell transfer is the fate of recipient cells. Recently, bone marrow mesenchymal stem cells (BM-MSCs) have been reported to provide mitochondria cancer rescue mitochondrial dysfunction in However, details mechanism not yet fully elucidated. In this study, we investigated humoral factors inducing (MT) mechanisms. BM-MSCs produced MT colorectal (CRC) damaged by 5-fluorouracil (5-FU), but were suppressed anti-high mobility group box-1 (HMGB1) antibody. treated with oxidized HMGB1 had increased expression MT-associated genes, whereas reduced did not. Inhibition nuclear factor–κB, a downstream factor signaling, significantly decreased gene expression. CRC showed stemness 5-FU sensitivity correlation levels. mouse subcutaneous tumor model CRC, from host BM-MSCs. These results suggest that induces MTs MSCs promotes stemness. Targeting may attenuate CRCs.
Language: Английский
Citations
0