Industrial-produced lemon nanovesicles ameliorate experimental colitis-associated damages in rats via the activation of anti-inflammatory and antioxidant responses and microbiota modification DOI Open Access
Vincenza Tinnirello, Maria Grazia Zizzo, Alice Conigliaro

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116514 - 116514

Published: April 3, 2024

Plant-derived nanovesicles (PDNVs) have recently emerged as natural delivery systems of biofunctional compounds toward mammalian cells. Considering their already described composition, anti-inflammatory properties, stability, and low toxicity, PDNVs offer a promising path for developing new preventive strategies several inflammatory diseases, among which the bowel disease (IBD). In this study, we explore protective effects industrially produced lemon vesicles (iLNVs) in rat model IBD. Characterization iLNVs reveals presence small particles less than 200 nm size profile bioactive enriched flavonoids organic acids with known beneficial properties. vitro studies on human macrophages confirm safety iLNVs, evidenced by reduced expression pro-inflammatory cytokines increased levels markers. As vivo experiments, pre-treatment significantly alleviates symptoms histological features 2,4 dinitrobenzensulfuric acid (DNBS)-induced colitis rats. Molecular pathway analysis modulation NF-κB Nrf2, indicating antioxidant effects. Finally, affects gut microbiota improving consistent colitis-related alterations. Overall, demonstrated role against emphasized potential managing IBD through multifaceted mechanisms.

Language: Английский

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice DOI Creative Commons
Stefano Bruscoli, Marta Febo, Carlo Riccardi

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 3, 2021

Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn’s (CD). IBD etiopathology is multifactorial involves alteration of immune cells chronic activation the inflammatory cascade against yet unknown environmental factors that trigger disease. therapy aims at improving quality life reducing risk disease-related complications to avoid need for surgery. There no specific cure IBDs, focus supportive measures use anti-inflammatory immunosuppressive drugs. Glucocorticoids (GCs) are powerful immunomodulatory agents used treat many acute diseases. GCs remain basic treatment moderate-to-severe IBD, but their limited by several important adverse drug effects. Topical administration a second-generation GCs, such as budesonide beclomethasone dipropionate (BDP), represents valid alternative older, systemic GCs. Administration shows promisingly high topical activity less toxicity, maintenance with these new in patients associated multiple In this review, we make comparative analysis efficacy first-generation treatment. Unraveling GC biology molecular level uncouple clinical benefits from detrimental effects important. One approach consider mediators, glucocorticoid-induced leucine zipper, which may have similar properties, avoids side This in-depth can help improve development outcomes therapies IBD.

Language: Английский

Citations

136
Inflammatory Bowel Diseases and Gut Microbiota DOI Open Access

Yuri Haneishi,

Yuma Furuya,

Mayu Hasegawa

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3817 - 3817

Published: Feb. 14, 2023

Inflammatory bowel disease (IBD) is an inflammatory of the gastrointestinal tract, incidence which has rapidly increased worldwide, especially in developing and Western countries. Recent research suggested that genetic factors, environment, microbiota, immune responses are involved pathogenesis; however, underlying causes IBD unclear. Recently, gut microbiota dysbiosis, a decrease abundance diversity specific genera, been as trigger for IBD-initiating events. Improving identifying bacterial species essential understanding pathogenesis treatment autoimmune diseases. Here, we review different aspects role played by provide theoretical basis modulating through probiotics, fecal transplantation, microbial metabolites.

Language: Английский

Citations

118
IBD disease-modifying therapies: insights from emerging therapeutics DOI
Niranjan G. Kotla, Yury Rochev

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 241 - 253

Published: Jan. 30, 2023

Language: Английский

Citations

67
Cross-scale multi-instance learning for pathological image diagnosis DOI Creative Commons
Ruining Deng, Can Cui,

Lucas W. Remedios

et al.

Medical Image Analysis, Journal Year: 2024, Volume and Issue: 94, P. 103124 - 103124

Published: Feb. 27, 2024

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is common solution for working by classifying bags of objects (i.e. sets smaller image patches). However, such processing typically performed at single scale (e.g., 20× magnification) WSIs, disregarding the vital inter-scale that key diagnoses human pathologists. In this study, we propose novel cross-scale MIL algorithm explicitly aggregate relationships into network pathological diagnosis. The contribution paper three-fold: (1) A (CS-MIL) integrates multi-scale and proposed; (2) toy dataset scale-specific morphological features created released examine visualize differential attention; (3) Superior performance on both in-house public datasets demonstrated our simple strategy. official implementation publicly available https://github.com/hrlblab/CS-MIL.

Language: Английский

Citations

20
Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery DOI

Maoyi Li,

Nanhui Liu, Jiafei Zhu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122584 - 122584

Published: May 8, 2024

Language: Английский

Citations

18
Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management DOI
Jinjin Pei,

Ranil Vikraman Kumarasamy,

Selvaraj Jayaraman

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

Citations

13
Therapeutic applications and potential biological barriers of nano-delivery systems in common gastrointestinal disorders: a comprehensive review DOI Creative Commons
Guoliang Zheng, Bao Zhang, Hou–Yong Yu

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)

Published: April 1, 2025

Language: Английский

Citations

5
Assessments of protodioscin’s antinociceptive and antidiarrheal properties: in vivo and in silico investigations on macromolecule binding affinity and modulatory effects DOI

Pompa Rani Ghosh,

Md. Sakib Al Hasan, Razina Rouf

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

3
A polysaccharide fromRosa roxburghiiTratt fruit attenuates high-fat diet-induced intestinal barrier dysfunction and inflammation in mice by modulating the gut microbiota DOI
Lei Wang, Pan Zhang, Chao Li

et al.

Food & Function, Journal Year: 2021, Volume and Issue: 13(2), P. 530 - 547

Published: Dec. 9, 2021

Obesity-induced colonic inflammation-stimulated colitis is one of the main causes colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis. In this work, protective effects a polysaccharide (RTFP) extracted from Rosa roxburghii Tratt fruit on barrier dysfunction inflammation were investigated using model mice. RTFP treatment repaired intestinal by increasing expression tight junction proteins (ZO-1, claudin-1, occludin) reducing levels cytokines, permeability, oxidative stress in mice fed high-fat diet. Most significantly, decreased gut ameliorated metabolic dysbiosis microflora decreasing Firmicutes/Bacteroidetes ratio, serum D-lactic acid lipopolysaccharides, inhibiting TLR4/NF-κB signaling pathway. Furthermore, significantly increased abundance beneficial bacteria (Ruminococcaceae, Muribaculaceae, Akkermansiaceae, etc.) but pathogenic bacteria. These findings indicate that can be used natural anti-inflammatory to reduce chronic

Language: Английский

Citations

82
The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF‐kappaB pathway DOI

Pegah Dejban,

Nasrin Nikravangolsefid, Mohsen Chamanara

et al.

Phytotherapy Research, Journal Year: 2020, Volume and Issue: 35(2), P. 835 - 845

Published: Sept. 14, 2020

Inflammatory bowel disease (IBD) is a lifelong and recurrent of the gastrointestinal tract that afflicts many people in world. Growing evidence has currently indicated dysfunction immune system, particularly toll‐like receptors 4 (TLR4) signaling pathway plays pivotal part pathogenesis IBD. TLR4 involved both efficacy treatment There are some medicinal products herbal medicines, which their role IBD through modulation been implicated. The purpose this review article to summarize those medicines.

Language: Английский

Citations

77