Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
29(11), P. 804 - 823
Published: Dec. 26, 2022
Abstract:
Edible
mushrooms
have
been
classified
as
“next-generation
food”
due
to
their
high
nutritional
value
coupled
with
biological
and
functional
potential.
The
most
extensively
studied
reported
mushroom
macromolecules
are
polysaccharides.
However,
macrofungi
proteins
peptides
also
a
representative
significant
bioactive
group.
Several
factors
such
species,
substrate
composition
harvest
time
significantly
impact
the
protein
content,
typically
ranging
between
19
35%
on
dry
weight
basis.
Proteins
work
based
shape
structure.
Numerous
extraction
methods,
including
chemical
non-conventional,
implications
yield
stability
will
be
discussed.
Beyond
potential,
great
advantage
of
is
uniqueness,
they
often
differ
from
animal,
vegetable,
microbial
proteins.
According
recently
published
reports,
relevant
include
lectins,
fungal
immunomodulatory
proteins,
ubiquitin-like
possessing
enzymatic
activity
ribonucleases
laccases,
other
enzymes
ergothioneine.
These
antioxidant,
antiviral,
antifungal,
antibacterial,
antihypertensive,
immunomodulatory,
antitumour,
antihypercholesterolemic
or
antihyperlipidemic,
antidiabetic
anti-inflammatory
properties,
which
improved
research
interest
contributed
increase
market
value.
This
review
provides
an
overview
biochemical
properties
main
groups
in
edible
mushrooms,
explicitly
focusing
biomedical
Although
rich
source
various
many
these
molecules
yet
identified
characterised.
Accordingly,
it
crucial
identify
characterise
new
origin,
opens
opportunity
for
further
investigation
bioactives
food,
nutraceutical,
medicinal
applications.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(2), P. 634 - 634
Published: Jan. 10, 2021
Medicinal
mushrooms
have
important
health
benefits
and
exhibit
a
broad
spectrum
of
pharmacological
activities,
including
antiallergic,
antibacterial,
antifungal,
anti-inflammatory,
antioxidative,
antiviral,
cytotoxic,
immunomodulating,
antidepressive,
antihyperlipidemic,
antidiabetic,
digestive,
hepatoprotective,
neuroprotective,
nephroprotective,
osteoprotective,
hypotensive
activities.
The
growing
interest
in
mycotherapy
requires
strong
commitment
from
the
scientific
community
to
expand
clinical
trials
propose
supplements
safe
origin
genetic
purity.
Bioactive
compounds
selected
medicinal
their
effects
mechanisms
vitro
vivo
studies
are
reported
this
review.
Besides,
we
analyzed
therapeutic
use
activities
mushrooms.
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 26, 2022
Background
Mushrooms
exist
as
an
integral
and
vital
component
of
the
ecosystem
are
very
precious
fungi.
have
been
traditionally
used
in
herbal
medicines
for
many
centuries.
Scope
Approach
There
a
variety
medicinal
mushrooms
mentioned
current
work
such
Agaricus,
Amanita,
Calocybe,
Cantharellus,
Cordyceps,
Coprinus,
Cortinarius,
Ganoderma,
Grifola,
Huitlacoche,
Hydnum,
Lentinus,
Morchella,
Pleurotus,
Rigidoporus,
Tremella,
Trametes
sp.,
etc.,
which
play
role
various
diseases
because
several
metabolic
components
nutritional
values.
Medicinal
can
be
identified
morphologically
on
basis
their
size,
color
(white,
black,
yellow,
brown,
cream,
pink
purple-brown,
etc.),
chemical
reactions,
consistency
stalk
cap,
mode
attachment
gills
to
stalk,
spore
mass,
further
at
molecular
level
by
Internal
Transcribed
Spacer
(ITS)
regions
gene
sequencing.
also
other
methods
that
recently
begun
identification
high-pressure
liquid
chromatography
(HPLC),
nuclear
magnetic
resonance
spectroscopy
(NMR),
microscopy,
thin-layer
(TLC),
DNA
sequencing,
gas
chromatography-mass
spectrometry
(GC-MS),
finger
printing,
ultra-performance
(UPLC),
fourier
transform
infrared
(FTIR),
quadrupole
time-of-flight
mass
(LCMS-TOF)
high-performance
(HPTLC).
Lately,
matrix-assisted
laser
desorption
ionization-time
flight
(MALDI-TOF
MS)
technique
is
Key
Finding
Conclusion
possess
biological
activities
like
anti-oxidant,
anti-cancer,
anti-inflammatory,
anti-aging,
anti-tumor,
anti-viral,
anti-parasitic,
anti-microbial,
hepatoprotective,
anti-HIV,
anti-diabetic,
others
will
this
article.
This
manuscript
provide
future
direction,
action
mechanisms,
applications,
recent
collective
information
mushrooms.
In
addition
unknown
metabolites
patented
active
included.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 13, 2022
Fungi
are
extremely
diverse
in
terms
of
morphology,
ecology,
metabolism,
and
phylogeny.
Approximately,
130
medicinal
activities
like
antitumor,
immunomodulation,
antioxidant,
radical
scavenging,
cardioprotective
antiviral
actions
assumed
to
be
produced
by
the
various
varieties
mushrooms.
The
polysaccharides,
present
mushrooms
β-glucans,
micronutrients,
antioxidants
glycoproteins,
triterpenoids,
flavonoids,
ergosterols
can
help
establish
natural
resistance
against
infections
toxins..
Clinical
trials
have
been
performed
on
Agaricus
blazei
Murrill
Kyowa
for
their
anticancer
effect
,
A.
its
antihypertensive
effects,
some
other
had
also
evaluated
neurological
effects.
human
evaluation
dose
studies
toxicity
was
from
literature
number
All
were
found
safe
at
a
2000
mg/kg
but
with
mild
side
safety
therapeutic
effectiveness
fungal
shifted
interest
biotechnologists
toward
nanobiotechnology
as
drug
delivery
system
due
vast
advantages
nanotechnology
systems.
In
complement
vital
nutritional
significance
mushrooms,
numerous
species
identified
sources
bioactive
chemicals.
Moreover,
there
unanswered
queries
regarding
safety,
efficacy,
critical
issues
that
affect
future
mushroom
medicine
development,
could
jeopardize
usage
twenty-first
century.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
10
Published: Jan. 16, 2024
There
is
a
huge
gap
between
food
production
and
the
exploding
population
demands
in
various
parts
of
world,
especially
developing
countries.
This
increases
chances
malnutrition,
leading
to
increased
disease
incidence
need
for
functional
foods
reduce
mortality.
Pleurotus
ostreatus
are
edible
mushrooms
that
cheaply
sourced
rich
nutrient
with
potential
be
harnessed
toward
addressing
present
future
crisis
while
serving
as
prevention
treatment.
study
evaluated
nutritional,
proximate,
vitamins
amino
acids
contents
.
The
proximate
composition
this
revealed
it
contains
43.42%
carbohydrate,
23.63%
crude
fiber,
17.06%
protein,
8.22%
ash,
1.21%
lipid
moisture
content
91.01
6.46%
fresh
dry
samples
ostreatus,
respectively
monosaccharide
disaccharide
profile
presence
glucose
(55.08
g/100
g),
xylose
(7.19
fructose
(19.70
galactose
(17.47
trehalose
(7.37
chitobiose
(11.79
maltose
(29.21
sucrose
(51.60
g)
lower
amounts
cellobiose
(0.01
erythrose
(0.48
other
unidentified
sugars.
Potassium,
Iron
Magnesium
were
highest
minerals
12.25
mg,
9.66
mg
7.00
amounts,
respectively.
vitamin
A
(2.93
IU/100
C
(16.46
mg/100
E
(21.50
B
B2
having
concentration
92.97
mg/kg.
acid
scores
showed
had
more
non-essential
(564.17
than
essential
(67.83
ratio
0.11.
Lysine
(23.18
was
aspartic
(492.12
mg/kg)
It
higher
acidic
acids,
492.12
g
(77.87%),
followed
by
neutral
106.66
(16.88%)
least
basic
23.18
(3.67%).
Based
on
nutritional
assessment
analyzed
study,
can
concluded
serve
an
important
source
exploited
meet
increasing
micronutrient
deficiencies
many
Food Chemistry Advances,
Journal Year:
2022,
Volume and Issue:
1, P. 100023 - 100023
Published: March 2, 2022
The
World
Health
Organization
(WHO)
declared
COVID-19
as
a
pandemic
on
March
11,
2020,
because
of
its
widespread
transmission
and
infection
rates.
unique
severe
disease
was
found
in
Wuhan,
China,
since
December
2019,
swiftly
spread
throughout
the
world.
Natural
chemicals
derived
from
herbal
medicines
medicinal
mushrooms
provide
significant
resource
for
development
novel
antiviral
drugs.
Many
natural
drugs
have
been
proven
to
properties
against
variety
virus
strains,
such
coronavirus
herpes
simplex
(HSV)..
In
this
research,
successful
dietary
treatments
different
COVID
illnesses
were
compared
potential
mushroom
products
therapy.
Google
Scholar,
Science
Direct,
PubMed,
Scopus,
search
keywords
like
COVID,
COVID-19,
SARS,
MERS,
mushrooms,
their
compounds
utilized.
review
literature
we
foucsed
popular
Agaricus
subrufescens
Peck,
blazei
Murill,
Cordyceps
sinensis
(Berk.)
Sacc.,
Ganoderma
lucidum
(Curtis.)
P.
Karst.,
Grifola
frondosa
(Dicks.)
Gray,
Hericium
erinaceus
(Bull.)
Pers.,
Inonotus
obliquus
(Arch.
Ex
Pers.)
Pilát.,
Lentinula
edodes
Pegler,
Pleurotus
ostreatus
(Jacq.)
Kumm.,
Poria
cocos
F.A.
Wolf,
Trametes
versicolor
(L.)
Lloyd.,.
Changed
forms
β-Glucan
seem
good
impact
viral
replication
suppression
might
be
used
future
studies.
However,
results
seems
terpenoids,
lectins,
glycoproteins,
lentinan,
galactomannan,
polysaccharides
are
promising
prophylactic
or
therapeutic
agents
COVID-19.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1183 - 1183
Published: March 6, 2024
Terpenes
and
their
derivatives
comprise
a
diverse
group
of
natural
compounds
with
versatile
medicinal
properties.
This
article
elucidates
the
general
characteristics
fungal
terpenes
terpenoids,
encompassing
structure
biogenesis.
The
focal
point
this
work
involves
comprehensive
overview
these
compounds,
highlighting
therapeutic
properties,
mechanisms
action,
potential
applications
in
treating
specific
skin
conditions.
Numerous
isolated
terpenoids
have
demonstrated
noteworthy
anti-inflammatory
anti-microbial
effects,
rivalling
or
surpassing
efficacy
currently
employed
treatments
for
inflammation
infections.
Due
to
well-documented
antioxidant
anti-cancer
attributes,
exhibit
promise
both
preventing
cancer.
sourced
from
fungi
display
capability
inhibit
tyrosinase,
suggesting
addressing
pigmentation
disorders
cancers
linked
melanogenesis
dysfunctions.
paper
further
disseminates
findings
clinical
vivo
research
on
conducted
thus
far.
