Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(5), P. 3921 - 3921

Published: Feb. 22, 2023

In recent years, cases of liver damage caused by ashwagandha herbal supplements have been reported from different parts the world (Japan, Iceland, India, and USA). Here, we describe clinical phenotype suspected ashwagandha-induced injury potential causative mechanism. The patient was admitted to hospital because jaundice. interview, it that he had taking for a year. Laboratory results showed an increase in total bilirubin, alanine transaminase (ALT), aspartate (AST), (gamma-glutamyl transpherase (GGT), alkaline phosphatase (ALP), cholesterol, triglycerides, ferritin. Based on symptoms additional tests, diagnosed with acute hepatitis referred facility higher reference rate exclude drug-induced injury. An R-value assessed, indicative hepatocellular result 24 h urine collection exceeded upper limit normal copper excretion twice. condition improved after intensive pharmacological treatment four plasmapheresis treatments. This case is another showing hepatotoxic cause cholestatic mixed severe view several documented unknown metabolic molecular mechanisms substances contained it, attention should be paid patients reporting use these products past presenting damage.

Language: Английский

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Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5486 - 5486

Published: March 13, 2023

Benign prostatic hyperplasia (BPH) is an age-related disorder, which one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years age, there a linear increase prostate volume BPH symptoms, are influenced by changes hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, microbiome that leads to cellular proliferation. While current pharmaceutical surgical treatments currently available, each treatment has serious side effects. This dilemma motived seek without negative effects from medicinal plants such as botanicals, phytochemicals, vitamins have established safety records. narrative overview focuses on several phytochemicals widely used emphasizes how, some cases, combinations these natural ingredients may provide better symptom relief compared utilization single plant product (monotherapy). Finally, this highlights vitro, vivo animal studies mainly clinical data journal reports published past 5 January 2018 2023 nutraceuticals. Notably, evolving perspective rethinking role usage play; is, they hold promise likely alleviate symptoms.

Language: Английский

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Challenges in herbal‐induced liver injury identification and prevention

Liver International, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract Herbal and dietary supplements (HDS) are being used worldwide at an increasing rate. Mirroring this trend, HDS‐induced liver injury, also known as injury (HILI), has increased significantly over the past three decades in Drug‐Induced Liver Injury Network (DILIN), now accounting for 20% of cases drug‐induced (DILI). There significant challenges identification prevention HILI due to varying presentations, ability make clear diagnosis, responsible ingredient, lack treatment, regulatory oversight HDS products confirm their ingredients ensure safety. The major implicated agents include anabolic steroids, green tea extract, garcinia cambogia, kratom, ashwagandha, turmeric multi‐ingredient nutritional supplements. Fortunately, with formation DILI consortiums across world, last decade seen advances at‐risk genetic phenotypes, use chemical analysis on supplements, publication data/injury patterns potentially risky HDS.

Language: Английский

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Modulation of Snack Foods: An Approach to Overcome Hidden Hunger in Children

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112777 - 112777

Published: March 1, 2025

Language: Английский

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Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats

Deleted Journal, Journal Year: 2024, Volume and Issue: 5(1), P. 200134 - 200134

Published: March 1, 2024

Cyclosporine-A (Cs-A), an immunosuppressant drug indicated for organ transplant patients has been associated with toxicities arising from activation of pathological signalling. Meanwhile Ginkgo biloba supplement (GBS) is antioxidant-enhancing herbal product widely used treating neurological and vascular dysfunctions. This study investigated the ameliorative effect GBS on cyclosporine-A induced cardiotoxicity in Wistar rats. The included 20 rats (n=5) they were treated as follows: group 1 received distilled water (10 mL/kg), 2 Cs-A (25 mg/kg), 3 (50 mg/kg) 4 mg/kg). All treatment done intraperitoneal 14 days thereafter, animals euthanised heart tissues harvested biochemical assays well immunohistochemical studies. Blood was also collected serum Our results revealed that reduces increase AST, ALT, ALP, LDH, GGT levels relative to control, which reversed by GBS. Also, increased oxido-nitrergic markers like MDA, NO, together elevated concentrations cholesterol, triglycerides, LDL, Creatine Kinase-MB, troponin-I, pro-inflammatory cytokines (IL-6, TNF-α) weight index reduced suppression Low-density lipoprotein, antioxidant (GSH, SOD, CAT), Na-K ATPase activities antiapoptotic element, Bcl-2 Additionally, signalling pathways including ERK1/2, mTOR ventricular thickness significantly alleviated treatment. findings suggest ameliorated Cs-A-induced activating mTOR/ERK1/2 pathways.

Language: Английский

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Sustainable analytical method for determination of bioactive compounds in solid oral formulations (capsules and tablets) containing green tea (Camellia sinensis) marketed in Brazil

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 40, P. 101655 - 101655

Published: June 12, 2024

Language: Английский

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A comprehensive update in herbal and dietary supplement–induced liver injury

Clinical Liver Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 1, 2024

Language: Английский

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Herbal Supplements That Have the Potential to Accelerate Recovery of Exercise-Induced Muscle Damage: Systematic Review

Retos, Journal Year: 2023, Volume and Issue: 51, P. 840 - 848

Published: Nov. 1, 2023

This study aims to analyze herbal supplements that have the potential accelerate recovery from exercise-induced muscle damage through a systematic review. Article searches were carried out using electronic databases originating Pubmed and Scopus published 2019 2022 keywords herbal, curcumin, garlic, ginger, tribulus, cinnamon, biomarkers, pain, inflammatory markers, antioxidant effects. The inclusion criteria in this literature review resulted 14 selected articles resulting screening process of 90 articles. results presented reveal fact there are significant changes related EIMD after consuming with doses varying between 500-2000 grams per day. In addition, other showed intervention products affected biomarkers oxidative stress. Therefore, provides evidence supplemental intake strategies essential for average athlete or individual minimize negative effects strenuous excessive training. concluded ingredients such as tribulus terrestris may help athletes individuals recover EIMD. Keywords: Biomarkers, EIMD, Inflammation, Nutrition, Supplementation, Recovery

Language: Английский

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