Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 200 - 200

Published: Feb. 4, 2022

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As result, infectious diseases have become more challenging or even impossible treat, leading an increase morbidity mortality. Despite the failure of conventional, traditional therapy, past two decades, no novel class antibiotics has been introduced. Consequently, several alternative strategies combat these (multi-) drug-resistant microorganisms identified. The purpose this review is gather consider that are being applied proposed as potential alternatives antibiotics. These include combination techniques target enzymes proteins responsible for resistant bacteria, drug delivery systems, physicochemical methods, unconventional techniques, including CRISPR-Cas system. may change treatment multi-drug-resistant pathogens human clinical settings.

Language: Английский

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Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

iScience, Journal Year: 2021, Volume and Issue: 24(5), P. 102443 - 102443

Published: April 19, 2021

Biofilm formation in living organisms is associated to tissue and implant infections, it has also been linked the contribution of antibiotic resistance. Thus, understanding biofilm development being able mimic such processes vital for successful antibiofilm treatments therapies. Several decades research have contributed building foundation developing vitro vivo models. However, no thing as an "all fit" or models currently available. In this review, addition presenting updated overview formation, we critically revise recent approaches improvement

Language: Английский

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Biofilms: Formation, drug resistance and alternatives to conventional approaches

AIMS Microbiology, Journal Year: 2022, Volume and Issue: 8(3), P. 239 - 277

Published: Jan. 1, 2022

<abstract> <p>Biofilms are aggregates of bacteria, in most cases, which resistant usually to broad-spectrum antibiotics their typical concentrations or even higher doses. A trend increasing multi-drug resistance biofilms, responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, at various sensitivity levels environmental factors and versatile infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts public health alternatives conventional approaches. Novel developments micro-biosystems that help reveal new treatment tools by sensing characterization biofilms will also be discussed. Understanding structure, physiology properties better helps eliminate them usage appropriate control novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems probiotics.</p> </abstract>

Language: Английский

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Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era

Plants, Journal Year: 2023, Volume and Issue: 12(17), P. 3077 - 3077

Published: Aug. 28, 2023

Undoubtedly, the advent of antibiotics in 19th century had a substantial impact, increasing human life expectancy. However, multitude scientific investigations now indicate that we are currently experiencing phase known as post-antibiotic era. There is genuine concern might regress to time before and confront widespread outbreaks severe epidemic diseases, particularly those caused by bacterial infections. These have demonstrated epidemics thrive under environmental stressors such climate change, depletion natural resources, detrimental activities wars, conflicts, antibiotic overuse, pollution. Moreover, bacteria possess remarkable ability adapt mutate. Unfortunately, current development insufficient, future appears grim unless abandon our approach generating synthetic rapidly lose their effectiveness against multidrug-resistant bacteria. Despite vital role modern medicine, medicinal plants served primary source curative drugs since ancient times. Numerous reports published over past three decades suggest could serve promising alternative ineffective combating infectious diseases. Over few years, phenolic compounds, alkaloids, saponins, terpenoids exhibited noteworthy antibacterial potential, primarily through membrane-disruption mechanisms, protein binding, interference with intermediary metabolism, anti-quorum sensing, anti-biofilm activity. optimize utilization effective drugs, further advancements omics technologies network pharmacology will be required order identify optimal combinations among these compounds or conjunction antibiotics.

Language: Английский

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Challenges of antibiotic resistance biofilms and potential combating strategies: a review

3 Biotech, Journal Year: 2021, Volume and Issue: 11(4)

Published: March 16, 2021

Language: Английский

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Pollutants affect algae-bacteria interactions: A critical review

Environmental Pollution, Journal Year: 2021, Volume and Issue: 276, P. 116723 - 116723

Published: Feb. 15, 2021

Language: Английский

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Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: July 21, 2021

Rising antibiotic resistance is a global threat that projected to cause more deaths than all cancers combined by 2050. In this review, we set summarize the current state of resistance, and give an overview emerging technologies aimed escape pre-antibiotic era recurrence. We conducted comprehensive literature survey &gt;150 original research review articles indexed in Web Science using “antimicrobial resistance,” “diagnostics,” “therapeutics,” “disinfection,” “nosocomial infections,” “ESKAPE pathogens” as key words. discuss impact nosocomial infections on spread multi-drug resistant bacteria, over existing developing strategies for faster diagnostics infectious diseases, novel approaches therapy finally hospital disinfection prevent MDR bacteria spread.

Language: Английский

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Bacterial biofilm infections, their resistance to antibiotics therapy and current treatment strategies

Biomedical Materials, Journal Year: 2022, Volume and Issue: 17(2), P. 022003 - 022003

Published: Feb. 2, 2022

Nearly 80% of human chronic infections are caused due to bacterial biofilm formation. This is the most leading cause for failure medical implants resulting in high morbidity and mortality. In addition, biofilms also known serious problems food industry. Biofilm impart enhanced antibiotic resistance become recalcitrant host immune responses persistent recurrent infections. It makes clinical treatment very difficult. Reduced penetration molecules through EPS, mutation target site, accumulation degrading enzymes, expression efflux pump genes probable causes antibiotics resistance. Accordingly, strategies like administration topical combined therapy with antimicrobial peptides considered alternate options overcome A number other remediation both inhibition dispersion established have been developed. The metallic nanoparticles (NPs) their oxides recently gained a tremendous thrust as antibiofilm unique features. present comprehensive review gives understanding mechanisms provides an overview various currently available strategies, focusing primarily on applications NPs oxides.

Language: Английский

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Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: June 29, 2023

The human–bacterial association is long-known and well-established in terms of both augmentations human health attenuation. However, the growing incidents nosocomial infections caused by ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus Klebsiella pneumoniae Acinetobacter baumannii Pseudomonas aeruginosa Enterobacter sp.) call for a much deeper understanding these organisms. Adopting holistic approach that includes science infection recent advancements preventing treating imperative designing novel intervention strategies against pathogens. In this regard, review captures ingenious commissioned master players, which are teamed up defenses team, equally, if not more, versatile potent through an analogy. We have taken basketball match as our analogy, dividing bacterial species into two teams playing with ball health. Through we make concept infectious biology more accessible.

Language: Английский

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It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 14, 2023

Abstract Multiple drug resistance poses a significant threat to public health worldwide, with substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small molecules produced during stationary phase. When cultures reach certain level growth, these regulate expression bound genes by acting as mirrors that reflect inoculum density. Gram-positive bacteria use peptide derivatives molecules, whereas Gram-negative fatty acid derivatives, majority can both types modulate target gene. Numerous natural synthetic QS inhibitors (QSIs) have been developed reduce pathogenesis. Applications QSI vital human health, well fisheries aquaculture, agriculture, water treatment.

Language: Английский

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