Potential Adverse Effects of Resveratrol: A Literature Review

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 2084 - 2084

Published: March 18, 2020

Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s benefits were first highlighted in early 1990s French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, attributed RE. However, results from available human clinical trials controversial concerning protective effects RE against diseases their sequelae. The reason for these conflicting findings varied but differences characteristics enrolled patients, doses used, duration supplementation proposed, at least part, as possible causes. In particular, optimal dosage capable maximizing without raising toxicity issues remains an area research. context, while there a consistent body literature on diseases, are relatively few reports investigating toxicity. Indeed, adverse reported following consumption RE; therefore, future studies long-term effects, well vivo humans needed. Furthermore, data interactions when combined with other therapies still lacking, related absorption bioavailability body. review, we collect summarize about side effects. process, analyze vitro that have addressed stilbenoid. These suggest has unexplored side. Finally, discuss new delivery methods being employed overcome low

Language: Английский

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Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

Food Research International, Journal Year: 2021, Volume and Issue: 142, P. 110189 - 110189

Published: Jan. 29, 2021

Language: Английский

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Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 699 - 699

Published: Feb. 22, 2021

The most prevalent diseases of our time, non-communicable (NCDs) (including obesity, type 2 diabetes, cardiovascular and some types cancer) are rising worldwide. All them share the condition an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have common malnutrition related to physiopathology. In this context, diet is greatest modulator system–microbiota crosstalk, much interest, new challenges, arising area precision nutrition as a way towards treatment prevention. It fact that westernized (WD) partly responsible for increased prevalence NCDs, negatively affecting both microbiota system. Conversely, other nutritional approaches, such Mediterranean (MD), positively influence system microbiota, proposed not only potential tool clinical management different disease conditions, but prevention health promotion globally. Thus, purpose review determine regulatory role components WD MD interplay, order understand, create awareness of, over key components.

Language: Английский

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The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 188 - 188

Published: Jan. 28, 2021

This review presents the comprehensive knowledge about bidirectional relationship between polyphenols and gut microbiome. The first part is related to polyphenols’ impacts on various microorganisms, especially bacteria, their influence intestinal pathogens. research data mechanisms of polyphenol action were collected together organized. impact groups bacteria both whole “microbiota” particular species, including probiotics, are presented. Moreover, present in food (bound matrix) was compared with purified (such as dietary supplements) well form derivatives glycosides) those aglycones. second paper discusses detail (pathways) role bacterial biotransformation most important polyphenols, production bioactive metabolites a significant human organism (both positive negative).

Language: Английский

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Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

The aging of population has become an issue great concern because its rapid increase. Aging is important risk factor many chronic diseases. Resveratrol could be found in foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, antioxidant, anti‐inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, antiaging effects. mechanisms were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, regulating apoptosis. effective safe compound for the prevention treatment age‐related In this review, we summarize effects on aging, life extension, several diseases, with special attention paid to action.

Language: Английский

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Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Molecular Nutrition & Food Research, Journal Year: 2020, Volume and Issue: 64(9)

Published: March 20, 2020

Abstract The full consensus on the role of dietary polyphenols as human‐health‐promoting compounds remains elusive. two‐way interaction between and gut microbiota (GM) (i.e., modulation GM by their catabolism GM) is determinant in polyphenols’ effects. identification human metabotypes associated with a differential microbial metabolism has opened new research scenarios to explain inter‐individual variability upon consumption. unequivocally identified so far are those involved isoflavones (equol and(or) O ‐desmethylangolesin producers versus non‐producers) ellagic acid (urolithin metabotypes, including only urolithin‐A (UM‐A), urolithin‐A, isourolithin‐A, urolithin‐B (UM‐B), non‐producers (UM‐0)). In addition, metabolites (phenolic‐derived postbiotics) such equol, urolithins, valerolactones, enterolactone, enterodiol, 8‐prenylnaringenin, among others, can exert health knowledge updated position taken here i) polyphenols, ii) evidence phenolic‐derived postbiotics health, iii) biomarkers clustering individuals depending (metabotyping) effects, iv) catecholamines illustrate intersection personalized nutrition precision medicine.

Language: Английский

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SIRT1 Activation by Natural Phytochemicals: An Overview

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 7, 2020

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+ as a cofactor. reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead tissue-specific degenerative events involved in the development several human pathologies, including cancer, neurodegeneration, cardiovascular disease. The most studied member this enzymes sirtuin 1 (SIRT1), associated with increasing insulin sensitivity. SIRT1 has been implicated both tumorigenic anticancer processes, regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders metabolism. Via regulation p53 deacetylation modulation autophagy, cellular response caloric restriction lifespan extension. In recent years, scientific interest focusing identification modulators led discovery novel small molecules targeting activity. This review will examine compounds natural origin recently found upregulate activity, such polyphenolic products fruits, vegetables, plants resveratrol, fisetin, quercetin, curcumin. We also discuss potential therapeutic effects these prevention treatment disorders, particular emphasis impact.

Language: Английский

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Resveratrol and Vascular Function

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(9), P. 2155 - 2155

Published: April 30, 2019

Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating expression NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing uncoupling. At same time, resveratrol inhibits synthesis endothelin-1 reduces oxidative stress both smooth muscle cells. Pathological stimuli-induced cell proliferation, vascular remodeling, arterial stiffness can be ameliorated as well. In addition, also modulates immune function, inhibition infiltration into wall, improves function perivascular adipose tissue. All these mechanisms contribute to protective effects on blood pressure vivo. Sirtuin 1, AMP-activated protein kinase, estrogen receptors represent major molecules mediating resveratrol.

Language: Английский

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Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

Acta Pharmaceutica Sinica B, Journal Year: 2019, Volume and Issue: 10(1), P. 3 - 18

Published: Dec. 10, 2019

Few medications are available for meeting the increasing disease burden of nonalcoholic fatty liver (NAFLD) and its progressive stage, steatohepatitis (NASH). Traditional herbal medicines (THM) have been used centuries to treat indigenous people with various symptoms but without clarified modern-defined types mechanisms. In modern times, NAFLD was defined as a common chronic leading more studies understand NAFLD/NASH pathology progression. THM garnered increased attention providing therapeutic candidates treating NAFLD. this review, new model called "multiple organs-multiple hits" is proposed explain mechanisms NASH Against model, effects frequently-studied THM-yielded single anti-NAFLD drug multiple herb reviewed, among which silymarin berberine already under U.S. FDA-sanctioned phase 4 clinical studies. Furthermore, experimental designs discovery from in discussed. The opportunities challenges reverse pharmacology pharmacokinetic concepts-guided strategies modernization global recognition highlighted. Increasing mechanistic evidence being generated support beneficial role discovery.

Language: Английский

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Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 19, 2020

Oral administration of resveratrol is able to ameliorate the progression diabetic nephropathy (DN); however, its mechanisms action remain unclear. Recent evidence suggested that gut microbiota involved in metabolism therapeutics. In current study, we sought determine whether anti-DN effects are mediated through modulation using genetic db/db mouse model DN. We demonstrate treatment mice relieves a series clinical indicators then show improves intestinal barrier function and ameliorates permeability inflammation. The composition microbiome was significantly altered compared control db/m mice. Dysbiosis characterized by low abundance levels Bacteroides, Alistipes, Rikenella, Odoribacter, Parabacteroides, Alloprevotella genera were reversed treatment, suggesting potential role for DN progression. Furthermore, fecal transplantation, derived from healthy resveratrol-treated mice, sufficient antagonize renal dysfunction, rebalance improve inflammation recipient These results indicate resveratrol-mediated changes may play an important mechanism resveratrol, which provides supporting gut-kidney axis

Language: Английский

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