To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity

Exposure and Health, Journal Year: 2022, Volume and Issue: 15(1), P. 33 - 51

Published: March 22, 2022

Abstract Micro- and nanoplastics (MNPs) are recognized as emerging contaminants, especially in food, with unknown health significance. MNPs passing through the gastrointestinal tract have been brought context disruption of gut microbiome. Several molecular mechanisms described to facilitate tissue uptake MNPs, which then involved local inflammatory immune responses. Furthermore, can act potential transporters (“vectors”) contaminants chemosensitizers for toxic substances (“Trojan Horse effect”). In this review, we summarize current multidisciplinary knowledge ingested their adverse effects. We discuss new insights into analytical modeling tools help us better understand deposition that might drive carcinogenic signaling. present bioethical basically re-consider “culture consumerism.” Finally, map out prominent research questions accordance Sustainable Development Goals United Nations.

Language: Английский

---

Water a major source of endocrine-disrupting chemicals: An overview on the occurrence, implications on human health and bioremediation strategies

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116097 - 116097

Published: May 12, 2023

Language: Английский

---

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 675 - 675

Published: Jan. 4, 2024

Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides type diet, calorie intake lack physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates their analogs, obesity. EDCs represent heterogeneous group that may influence hormonal regulation mass adipose tissue morphology. Based on available from mechanistic, animal epidemiological studies including meta-analyses, evidence points towards contribution to development obesity, associated disorders obesity-related dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility obesity; (3) influencing neuroendocrine signals responsible appetite satiety; (4) promoting proinflammatory milieu in inducing state chronic subclinical inflammation; (5) dysregulating gut microbiome immune homeostasis; (6) thermogenic tissue. Critical periods exposure obesogenic are prenatal, neonatal, pubertal reproductive periods. Interestingly, even at low doses promote transgenerational inheritance adult obesity subsequent generations. The aim this review is summarize role EDCs, specifically BPA phthalate plasticizers, taking into account vitro, epidemiologic studies; discuss mechanisms linking analyze effects critical exposure; present interesting perspectives, preventive measures research area.

Language: Английский

---

Ultra-Processed Foods and Childhood Obesity: Current evidence and perspectives

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

---

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(9), P. 4807 - 4807

Published: May 1, 2021

Non-alcoholic fatty liver disease (NAFLD) is considered the most common disorder, affecting around 25% of population worldwide. It a complex spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light this, numerous efforts have been carried out in recent years order to clarify its pathogenesis create new prevention strategies. Currently, essential role environmental pollutants NAFLD development recognized. Particularly, endocrine-disrupting chemicals (EDCs) notable influence. EDCs can be classified natural (phytoestrogens, genistein, coumestrol) or synthetic, latter ones further subdivided into industrial (dioxins, polychlorinated biphenyls, alkylphenols), agricultural (pesticides, insecticides, herbicides, fungicides), residential (phthalates, polybrominated bisphenol A), pharmaceutical (parabens). Several experimental models proposed mechanism involving this group substances disruption hepatic metabolism, promotes NAFLD. These include an imbalance between lipid influx/efflux liver, mitochondrial dysfunction, inflammation, epigenetic reprogramming. concluded that exposure might play crucial initiation evolution. However, investigations supporting these effects humans are required.

Language: Английский

---

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

Nutrients, Journal Year: 2020, Volume and Issue: 12(7), P. 1921 - 1921

Published: June 29, 2020

Obesity is a growing health threat worldwide. Administration of probiotics in obesity has also parallelly increased but without any protocolization. We conducted systematic review exploring the administration pattern probiotic strains and effective doses for obesity-related disorders according to their capacity positively modulating key biomarkers microbiota dysbiosis. Manuscripts targeting administered clinical studies were sought. MEDLINE, Scopus, Web Science, Cochrane Library databases searched using keywords during last fifteen years up April 2020. Two independent reviewers screened titles, abstracts, then full-text papers against inclusion criteria PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines. From 549 interventional reports identified, we filtered 171 eligible studies, from which 24 assays used calculating intervention total (ITD) specific species administered. Nine these excluded second-step because no data on gut modulation was found. Six trials (CT) 9 animal retained analysis complete outcome prioritized (body mass index (BMI), adiposity parameters, glucose, plasma lipid biomarkers, hormones). Lactobacillus spp. double compared

Language: Английский

---

Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 42(3), P. 295 - 353

Published: Jan. 3, 2021

Abstract The burden of adverse pregnancy outcomes such as preterm birth and low weight is considerable across the world. Several risk factors for have been identified. One factor receiving attention in recent years gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed a multitude environmental with known properties, evidence suggests these EDCs potential disrupt maternal-fetal environment culminating outcomes. This review addresses impact maternal fetal natural man-made disrupting milieu human leading outcomes—a adult-onset noncommunicable diseases, role lifestyle play mitigating or amplifying effects EDCs, underlying mechanisms mediators involved, research directions on which focus future investigations help alleviate EDC exposure.

Language: Английский

---

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 2969 - 2969

Published: March 9, 2022

BPA is one of the most common endocrine disruptors that widely being manufactured daily nationwide. Although scientific evidence supports claims negative effects on humans, there also suggesting a low level safe. However, numerous in vivo trials contraindicate with this claim and high possibility exposure could lead to obesity. It has been speculated does not stop exposed subjects only, but may cause transgenerational effects. Direct disruption regulation, neuroimmune signaling pathways, as well gut microbiata, identified be interrupted by exposure, leading overweight or In these instances, cardiovascular complications are primary notable clinical signs. regard claim, review paper discusses role obesity perspective disruptions possible arise due BPA. Thus, aim outline changes microbiota mechanisms involved relation To identify potentially relevant articles, depth search was done databases Nature, PubMed, Wiley Online Library, Medline & Ovid from past 5 years. According Boolean operator guideline, selected keywords such (1) OR environmental chemical AND fat LDL obese phenocopy (2) Endocrine lipodystrophy (3) Lipid profile weight effect (4) gene signaling, were used terms. Upon screening, 11 articles finalized further reviewed data extraction tables containing information type animal model duration dosage lipid genes, mechanism, any signal involved, (5) created. toto, study indicates chances affecting associated lipolysis, Therefore, scoping recapitulates current trials. The biomarkers, safety concerns, recommended dosage, impact COVID-19 briefly described.

Language: Английский

---

Triclosan: A Small Molecule with Controversial Roles

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 735 - 735

Published: May 30, 2022

Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective controlling biofilm formation maintaining gingival health. Given its broad usage, TCS present ubiquitously the environment. strong lipophilicity accumulation ability organisms, it potentially harmful to biohealth. Several reports suggest toxicity of this compound, which inserted class endocrine disrupting chemicals (EDCs). In September 2016, was banned by U.S. Food Drug Administration (FDA) European Union soap products. Despite these problems, application products within certain limits still allowed. Today, unclear whether truly toxic mammals adverse effects continuous, long-term, low concentration exposure remain unknown. Indeed, some recent use as repositioned drug for cancer treatment cutaneous leishmaniasis. scenario necessary investigate advantages disadvantages understand advisable or not. This review intends highlight pros cons that are associated with humans.

Language: Английский

---

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1918 - 1918

Published: May 3, 2022

Increasing evidence on the significance of nutrition in reproduction is emerging from both animal and human studies, suggesting a mutual association between female fertility. Different “fertile” dietary patterns have been studied; however, humans, conflicting results or weak correlations are often reported, probably because individual variations genome, proteome, metabolome, microbiome extent exposure to different environmental conditions. In this scenario, “precision nutrition”, namely personalized based deep phenotyping metabolomics, microbiome, nutrigenetics each case, might be more efficient for infertile patients than applying generic nutritional approach. review, we report new insights into management patients, discussing main nutrigenetic, nutrigenomic, microbiomic aspects that should investigated achieve effective interventions. Specifically, will focus low-grade chronic inflammation, which associated with several infertility-related diseases.

Language: Английский

---