Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases DOI Creative Commons
Guy Rousseau

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(2), P. 54 - 54

Published: Jan. 23, 2021

Several cardioprotective mechanisms attributed to Omega-3 polyunsaturated fatty acids (PUFAs) have been studied and widely documented. However, in recent years, studies supported the concept that intestinal microbiota can play a much larger role than we had anticipated. Microbiota could contribute several pathologies, including cardiovascular diseases. Indeed, an imbalance has often reported patients with disease produces low-level inflammation. This inflammation contributes to, more or less, long-term development of It also worsen symptoms consequences these pathologies. According some studies, omega-3 PUFAs diet restore this mitigate its harmful effects on Many are involved included: (1) reduction bacteria producing trimethylamine (TMA); (2) increase butyrate, which anti-inflammatory properties; (3) decrease production pro-inflammatory cytokines. Additionally, would help maintain better integrity barrier, thereby preventing translocation contents into circulation. review will summarize gut micro-biota potential impact cardiac health.

Language: Английский

Human microbiome and metabolic health: An overview of systematic reviews DOI
Nathalie Michels, Semi Zouiouich,

Bert Vanderbauwhede

et al.

Obesity Reviews, Journal Year: 2022, Volume and Issue: 23(4)

Published: Jan. 3, 2022

Summary To summarize the microbiome's role in metabolic disorders (insulin resistance, hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty liver disease [NAFLD], and syndrome), systematic reviews on observational or interventional studies (prebiotics/probiotics/synbiotics/transplant) were searched MEDLINE Embase until September 2020. The 87 selected included 57 meta‐analyses. Methodological quality (AMSTAR2) was moderate 62%, 12% low, 26% critically low. Observational obesity (10 reviews) reported less gut bacterial diversity with higher Fusobacterium , Lactobacillus reuteri Bacteroides fragilis Staphylococcus aureus whereas lower Methanobrevibacter plantarum Akkermansia muciniphila Bifidobacterium animalis compared nonobese. For diabetes ( n = 1), same found for A. Ruminococcus Faecalibacterium Roseburia vulgatus several spp. NAFLD 2), Firmicutes, Rikenellaceae, Ruminococcaceae, Escherichia detected. Discriminating bacteria overlapped between disorders, those high abundance being often involved inflammation, low used as probiotics. Meta‐analyses 54) 522 associations: 54% statistically significant intermediate effect size between‐study heterogeneity. Meta‐evidence highest probiotics lowest fecal transplant. Future avenues include better methodological quality/comparability, testing functional differences, new intervention strategies, considerating other body habitats kingdoms.

Language: Английский

Citations

83
The effects of prebiotic, probiotic or synbiotic supplementation on overweight/obesity indicators: an umbrella review of the trials’ meta-analyses DOI Creative Commons
Niloufar Rasaei, Mohammadreza Heidari, Fataneh Esmaeili

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 20, 2024

There is controversial data on the effects of prebiotic, probiotic, or synbiotic supplementations overweight/obesity indicators. Thus, we aimed to clarify this role biotics through an umbrella review trials' meta-analyses.

Language: Английский

Citations

11
Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions DOI
Aleah Holmes, Carson Finger, Diego Morales‐Scheihing

et al.

Translational research, Journal Year: 2020, Volume and Issue: 226, P. 39 - 56

Published: Aug. 2, 2020

Language: Английский

Citations

66
Representative Bacillus sp. AM1 from Gut Microbiota Harbor Versatile Molecular Pathways for Bisphenol A Biodegradation DOI Open Access
Ana López‐Moreno, Alfonso Torres-Sánchez, Inmaculada Acuña

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(9), P. 4952 - 4952

Published: May 7, 2021

Human gut microbiota harbors numerous microbial species with molecular enzymatic potential that impact on the eubiosis/dysbiosis and health/disease balances. Microbiota isolation description of their specific features remain largely unexplored. In present study, we focused cultivation selection able to tolerate or biodegrade endocrine disruptor bisphenol A (BPA), a xenobiotic extensively found in food plastic containers. Chemical addition methods for directed isolation, culturing, Whole Genome Sequencing (WGS), phylogenomic identification, gene-encoding searches have been applied isolate microorganisms, assess BPA metabolization potential, describe encoded catabolic pathways. BPA-tolerant strains were isolated from 30% infant fecal culture libraries analyzed. Most phylogenetically related operational taxonomic group Bacillus amyloliquefaciens spp. Importantly, WGS analysis representative strain, sp. AM1 identified four complete pathways involved degradation indicating its versatility high degrade BPA. Pathways Exopolysaccharide (EPS) Polyhydroxyalkanates (PHA) biopolymer synthesis also phenotypically confirmed by transmission electronic microscopy (TEM). These biopolymers could generally contribute capture and/or deposit xenobiotics.

Language: Английский

Citations

41
Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet DOI Open Access
Yanzhou Hu, Jia Xu,

Yao Sheng

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1868 - 1868

Published: April 29, 2022

Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating gut microbiota, we administered mice low-fat diet or high-fat containing different dosages (mass fraction: 0%, 2.5%, 5% 10%). The body weight, adipose tissue GTT, ITT, blood lipids, serum biomarkers liver/kidney function, microbiota function were measured analyzed after 6 weeks treatment. results showed prevented obesity, maintained glucose homeostasis beneficially modulated microbiota. modified composition functions in obese make them similar to those lean mice, which contributed weight loss. significantly increased relative abundance Oscillospira, Lactobacillus group Bifidobacterium, while decreased Bacteroides Roseburia. prediction upregulated lipid metabolism, carbohydrate bile acid biosynthesis, it downregulated adipocytokine signaling pathway steroid hormone biosynthesis. Correlation analysis further suggested potential relationship among In conclusion, all indicated that ameliorated at least partly by

Language: Английский

Citations

33
Combined effects of yacon flour and probiotic yogurt on the metabolic parameters and inflammatory and insulin signaling proteins in high‐fat‐diet‐induced obese mice DOI

Juciane de Abreu Ribeiro Pereira,

Maria de Fátima Píccolo Barcelos,

Eduardo Valério Villas Boas

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2022, Volume and Issue: 102(15), P. 7293 - 7300

Published: June 27, 2022

Prebiotics and probiotics may be effective dietary components that can alter the gut microbiota of host and, consequently, overcome imbalances associated with obesity. This work aimed to evaluate synergistic isolated effects mechanisms by which probiotic yogurt containing Bifidobacterium animalis and/or Lactobacillus acidophilus yacon flour metabolic parameters inflammatory insulin signaling proteins in diet-induced obese mice. Swiss mice were fed a high-fat diet (n = 48) or standard (control; n 6) for 56 days. The 42 gained most weight selected divided into seven groups received different combinations flour. After 30 days, biochemical (blood glucose, serum total cholesterol, triacylglycerols), crude fat excretion feces, periepididymal assessed an immunoblotting analysis interleukin-1β was conducted.The combination two strains exerted positive on evaluated, such as decreased body (-6.5%; P < 0.05), fasting glucose (-23.1%; triacylglycerol levels (-21.4%; 0.05) accumulation (-44.2%; 0.05). There decrease markers (P 0.001) improvement 0.001).The prebiotic food matrix exert protective effect against obesity-associated inflammation, improving resistance, even short term. © 2022 Society Chemical Industry.

Language: Английский

Citations

29
Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: An umbrella meta-analysis DOI
Meysam Zarezadeh, Vali Musazadeh, Amir Hossein Faghfouri

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 183, P. 106397 - 106397

Published: Aug. 15, 2022

Language: Английский

Citations

29
Anti-obesity properties of probiotics; a considerable medical nutrition intervention: Findings from an umbrella meta-analysis DOI
Vali Musazadeh, Meysam Zarezadeh, Faezeh Ghalichi

et al.

European Journal of Pharmacology, Journal Year: 2022, Volume and Issue: 928, P. 175069 - 175069

Published: June 1, 2022

Language: Английский

Citations

27
Polyunsaturated fatty acids and metabolic health: novel insights DOI
Ivana Djuričić, Philip C. Calder

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2022, Volume and Issue: 25(6), P. 436 - 442

Published: Aug. 9, 2022

This review aims to discuss the potential roles of omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) in prevention treatment metabolic diseases, provide latest evidence from epidemiological clinical studies, highlight novel insights into this field.Higher dietary or circulating ω-3 PUFA levels are related a lower risk syndrome. Novel findings obesity indicate higher proportions ω-6 PUFAs, modulated oxylipin profile an altered transcriptome subcutaneous white adipose tissue, that seem resistant effects PUFAs compared with what occurs normal weight individuals. may improve blood lipid glycemic outcomes patients type 2 diabetes mellitus reduce liver fat nonalcoholic disease (NAFLD); several recent meta-analyses support these effects. Genetic background affects inter-individual variability insulin sensitivity response supplementation. have prebiotic effects, altering gut microbiota.Although for health benefits is strong, suggest more personalized approach intake individuals at high diseases.

Language: Английский

Citations

25
Effects of probiotic/synbiotic supplementation on body weight in patients with diabetes: a systematic review and meta-analyses of randomized-controlled trials DOI Creative Commons
Sepideh Soltani, Marziyeh Ashoori, Fereshteh Dehghani

et al.

BMC Endocrine Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 21, 2023

Abstract Objective The aim of the present study was to assess effect probiotic/synbiotic supplementation on anthropometric measures in adults with diabetes, independent body weight. Methods PubMed, Scopus, Web Sciences and Cochrane Library were searched for randomized controlled trials (RCTs) up until December 14, 2022. sizes pooled using an inverse-variance random-effects model. methodological quality studies as well evidence assessed standard tools. Results Thirty-two RCTs met established inclusion criteria. Overall, compared respective control groups, resulted a significant reduction weight (weighted mean difference [WMD]: -0.50 kg; 95% CI: -0.83, -0.17; I 2 = 79.8%, n 27 studies]), mass index (WMD: -0.24 kg/m ; -0.39, -0.09; 85.7%, 30 studies), waist circumference -0.90 cm; -1.13, -0.52; 0%, 11 studies). However, hip ratio not significantly improved. Conclusions Our analysis revealed that may assist management patients especially when consumed at higher doses, younger adults, participants obesity. more are needed elucidate anti-obesity effects specific strains probiotics/synbiotics.

Language: Английский

Citations

14