mSystems, Journal Year: 2023, Volume and Issue: 9(1)
Published: Dec. 18, 2023
Probiotics can effectively improve a variety of neurological diseases, but there is little research on autism, and the specific mechanism unclear. In this study, shotgun metagenomics analysis was used to investigate preventive therapeutic effects
Language: Английский
EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104527 - 104527
Published: March 22, 2023
Language: Английский
Citations
306
Biology, Journal Year: 2022, Volume and Issue: 11(1), P. 61 - 61
Published: Jan. 2, 2022
There is growing evidence of studies associating COVID-19 survivors with increased mental health consequences. Mental implications related to a infection include both acute and long-term Here we discuss COVID-19-associated psychiatric sequelae, particularly anxiety, depression, post-traumatic stress disorder (PTSD), drawing parallels past coronavirus outbreaks. A literature search was completed across three databases, using keywords for relevant articles. The cause may directly correlate the through direct indirect mechanisms, but underlying etiology appears more complex multifactorial, involving environmental, psychological, biological factors. Although most risk factors prevalence rates vary various studies, being female gender having history disorders seem consistent. Several will be presented, demonstrating presenting higher consequences than general population. possible mechanisms by which severe respiratory syndrome 2 (SARS-CoV-2) enters brain, affecting central nervous system (CNS) causing these discussed, concerning SARS-CoV-2 entry via angiotensin-converting enzyme (ACE-2) receptors immune inflammatory signaling on neuropsychiatric disorders. Some therapeutic options also considered.
Language: Английский
Citations
97
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(4), P. 1908 - 1919
Published: March 2, 2022
Language: Английский
Citations
86
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: July 26, 2023
Pro-and prebiotics have been indicated to modulate the gut-brain axis, which supportive impacts on central nervous systems, and decrease or control incidence of some mental disorders such as depression, anxiety, autism, Schizophrenia, Alzheimer’s. In this review, complex communications among microbiota, gut, brain, also recent scientific findings possible action mechanisms pro-and discussed. The results shown that can improve function system play an important role in prevention treatment brain disorders; however, order prove these effects conclusively firmly use compounds a therapeutic way, more studies are needed, especially human studies/clinical trials.
Language: Английский
Citations
75
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10322 - 10322
Published: June 19, 2023
Several studies have shown that the gut microbiota influences behavior and, in turn, changes immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding microbiota. Although composition/function intestinal appears to affect central nervous (CNS) activities through multiple mechanisms, accurate epidemiological evidence clearly explains connection between CNS pathology and dysbiosis is not yet available. The enteric (ENS) a separate branch autonomic (ANS) largest part peripheral (PNS). It composed vast complex network neurons which communicate via several neuromodulators neurotransmitters, like those found CNS. Interestingly, despite its tight connections both PNS ANS, ENS also capable some independent activities. This concept, together suggested role played microorganisms metabolome onset progression neurological (neurodegenerative, autoimmune) psychopathological (depression, disorders, autism) diseases, large number investigations exploring functional physiopathological implications microbiota/brain axis.
Language: Английский
Citations
61
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3340 - 3340
Published: March 15, 2024
Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies expand boundaries neuropharmacology, studies from field have highlighted gut microbiota’s role modulating these disorders. These alterations may influence brain’s processes through brain–gut axis, multifaceted bidirectional system that establishes connection between enteric central nervous systems. Thus, probiotic prebiotic supplements are meant overall health play an insightful alleviating psychiatric symptoms, such templates major depressive disorder, anxiety, or schizophrenia. Moreover, administration psychotropic drugs has been revealed induce specific changes microbiome’s diversity, suggesting their potential utility combating bacterial infections. This review emphasizes intricate correlations microbiota, mentioning promising approaches regard modulation treatments, well antimicrobial effects medication.
Language: Английский
Citations
21
Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 237 - 255
Published: March 21, 2024
This review aims to argue how using probiotics can improve anxiety and depressive behaviour without adverse effects, also exploring the impact of postbiotics on it. Specifically, have drawn more attention as effective alternative treatments, considering rising cost antidepressant anti-anxiety drugs high risk side effects. Depression disorders are among most common mental illnesses in world's population, characterised by low mood, poor general interest, cognitive or motor dysfunction. Thus, this study analyzed published literature anxiety, depression, probiotic supplementation from PubMed Scopus, focusing last twenty years. focused effect health they because their extensive clinical applications positive various diseases. Numerous studies demonstrated gut microbiota might be critical for mood regulation affect host regulating gut-brain axis. By comparing different works analysed, it was possible identify a strategy which selected employed and, at same time, assess optimised postbiotics, an innovation well-being humans.
Language: Английский
Citations
20
Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1382 - 1382
Published: March 13, 2023
Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents key domain healthcare, which has limited, adverse-effect prone treatment options, probiotics may hold be novel, customizable for depression. Clinical depression is common, potentially debilitating condition that amenable precision psychiatry-based approach utilizing probiotics. Although our understanding not yet reached sufficient level, this could therapeutic can tailored specific individuals with own unique set characteristics issues. Scientifically, use as valid basis rooted in microbiota-gut-brain axis (MGBA) mechanisms, play role pathophysiology theory, appear ideal adjunct therapeutics major depressive disorder (MDD) stand-alone mild MDD revolutionize disorders. there wide range an almost limitless combinations, review aims narrow focus most widely commercialized studied strains, namely Lactobacillus Bifidobacterium, bring together arguments usage patients (MDD). Clinicians, scientists, industrialists critical stakeholders exploring groundbreaking concept.
Language: Английский
Citations
36
Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Feb. 9, 2023
Introduction Many psychiatric illnesses have been linked to the gut microbiome, with supplements such as probiotics showing some efficacy in alleviating symptoms of illnesses. The aim this review is evaluate current literature investigating effects adjuvant probiotic or synbiotic administration combination first-line treatments for Method A systematic search four databases was conducted using key terms related illnesses, and probiotics. All results were then evaluated based on specific eligibility criteria. Results Eight studies met criteria analyzed reported changes outcome measures used assess illness tolerability treatment. Major Depressive Disorder (MDD) ( n = 5) Generalized Anxiety (GAD) 1) found treatment be more efficacious improving than alone placebo. schizophrenia 2) no significant difference clinical outcomes, but it improve antipsychotics. Discussion conclusion findings included suggest use selective serotonin reuptake inhibitors (SSRIs) MDD GAD superior SSRI alone. Probiotic antipsychotics could beneficial antipsychotics, these do not that would result improved outcomes schizophrenia.
Language: Английский
Citations
35
Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 132, P. 103 - 120
Published: Jan. 11, 2023
Language: Английский
Citations
33