Nutrients,
Journal Year:
2024,
Volume and Issue:
16(5), P. 590 - 590
Published: Feb. 21, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
highly
fatal
neurodegenerative
disorder
characterized
by
the
progressive
wasting
and
paralysis
of
voluntary
muscle.
Despite
extensive
research,
etiology
ALS
remains
elusive,
effective
treatment
options
are
limited.
However,
recent
evidence
implicates
gut
dysbiosis
gut-brain
axis
(GBA)
dysfunction
in
pathogenesis.
Alterations
to
composition
diversity
microbial
communities
within
flora
have
been
consistently
observed
patients.
These
changes
often
correlated
with
disease
progression
patient
outcome,
suggesting
that
GBA
modulation
may
therapeutic
potential.
Indeed,
targeting
microbiota
has
shown
be
neuroprotective
several
animal
models,
alleviating
motor
symptoms
mitigating
progression.
translation
these
findings
human
patients
challenging
due
complexity
pathology
varying
microbiota.
This
review
comprehensively
summarizes
current
literature
on
ALS-related
dysbiosis,
focusing
implications
dysfunction.
It
delineates
three
main
mechanisms
which
contributes
pathology:
compromised
intestinal
barrier
integrity,
metabolic
dysfunction,
immune
dysregulation.
also
examines
preclinical
potential
gut-microbiota-modulating
agents
(categorized
as
prebiotics,
probiotics,
postbiotics)
ALS.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(4), P. 634 - 634
Published: March 22, 2024
The
bidirectional
relationship
between
the
gut
microbiota
and
nervous
system
is
known
as
microbiota-gut-brain
axis
(MGBA).
MGBA
controls
complex
interactions
brain,
enteric
system,
gut-associated
immune
neuroendocrine
systems,
regulating
key
physiological
functions
such
response,
sleep,
emotions
mood,
food
intake,
intestinal
functions.
Psychobiotics
are
considered
tools
with
potential
to
modulate
through
preventive,
adjunctive,
or
curative
approaches,
but
their
specific
mechanisms
of
action
on
many
aspects
health
yet
be
characterized.
This
narrative
review
perspectives
article
highlights
paradigms
needing
attention
scope
probiotics
applications
in
human
increases,
a
growing
body
evidence
supporting
systemic
beneficial
effects.
However,
there
limitations
overcome
before
establishing
extent
which
we
can
incorporate
management
neuropsychiatric
disorders.
Although
this
uses
term
general
manner,
it
remains
important
study
at
strain
level
most
cases.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
15(5), P. 2168 - 2168
Published: Jan. 1, 2024
Alzheimer's
disease
(AD)
is
an
age-dependent
neurodegenerative
characterized
by
extracellular
Amyloid
Aβ
peptide
(Aβ)
deposition
and
intracellular
Tau
protein
aggregation.
Glia,
especially
microglia
astrocytes
are
core
participants
during
the
progression
of
AD
these
cells
mediators
clearance
degradation.
The
microbiota-gut-brain
axis
(MGBA)
a
complex
interactive
network
between
gut
brain
involved
in
neurodegeneration.
MGBA
affects
function
glia
central
nervous
system
(CNS),
microbial
metabolites
regulate
communication
microglia;
however,
whether
such
part
pathophysiology
remains
unknown.
One
potential
links
bilateral
gut-brain
tryptophan
(Trp)
metabolism.
microbiota-originated
Trp
its
enter
CNS
to
control
microglial
activation,
activated
subsequently
affect
astrocyte
functions.
present
review
highlights
role
pathology,
roles
per
se
metabolism
as
microbiota
communications.
We
(i)
discuss
derivatives
microglia-astrocyte
crosstalk
from
bioinformatics
perspective,
(ii)
describe
polarization
(iii)
summarize
therapeutic
target.
Finally,
we
perspective
microglia,
well
crosstalk,
inspire
discovery
novel
therapeutics.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(2), P. 202 - 202
Published: Feb. 5, 2024
Alzheimer’s
disease
is
a
progressive
neurodegenerative
disorder
with
complex
etiology,
and
effective
interventions
to
prevent
or
delay
its
onset
remain
global
health
challenge.
In
recent
years,
there
has
been
growing
interest
in
the
potential
role
of
probiotic
vitamin
supplementation
as
complementary
strategies
for
prevention.
This
review
paper
explores
current
scientific
literature
on
use
probiotics
vitamins,
particularly
A,
D,
E,
K,
B-complex
context
prevention
management.
We
delve
into
mechanisms
through
which
may
modulate
gut–brain
interactions
neuroinflammation
while
vitamins
play
crucial
roles
neuronal
cognitive
function.
The
also
examines
collective
impact
this
combinational
therapy
reducing
risk
factors
associated
disease,
such
oxidative
stress,
inflammation,
gut
dysbiosis.
By
providing
comprehensive
overview
existing
evidence
mechanisms,
aims
shed
light
promise
co-supplementation
multifaceted
approach
combat
offering
insights
possible
avenues
future
research
clinical
application.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: March 6, 2024
The
lack
of
affordable
and
effective
therapeutics
against
cognitive
impairment
has
promoted
research
toward
alternative
approaches
to
the
treatment
neurodegeneration.
In
recent
years,
a
bidirectional
pathway
that
allows
gut
communicate
with
central
nervous
system
been
recognized
as
gut-brain
axis.
Alterations
in
microbiota,
dynamic
population
trillions
microorganisms
residing
gastrointestinal
tract,
have
implicated
variety
pathological
states,
including
neurodegenerative
disorders
such
Alzheimer’s
disease
(AD).
However,
probiotic
an
accessible
adjuvant
therapy
for
correction
dysbiosis
AD
not
thoroughly
explored.
Here,
we
sought
correct
mouse
model
supplementation,
intent
exploring
its
effects
on
progression.
Transgenic
3xTg-AD
mice
were
fed
control
or
diet
(
Lactobacillus
plantarum
KY1032
curvatus
HY7601
)
12
weeks,
latter
leading
significant
increase
relative
abundance
Bacteroidetes
.
Cognitive
functions
evaluated
via
Barnes
Maze
trials
improvements
memory
performance
detected
probiotic-fed
mice.
Neural
tissue
analysis
entorhinal
cortex
hippocampus
10-month-old
demonstrated
astrocytic
microglial
densities
reduced
supplemented
diet,
changes
more
pronounced
female
addition,
elevated
numbers
neurons
suggested
neuroprotection
induced
by
supplementation.
Our
results
suggest
supplementation
could
be
delaying
mitigating
early
stages
neurodegeneration
animal
model.
It
is
vital
explore
new
possibilities
palliative
care
neurodegeneration,
provide
inexpensive
easily
implemented
clinical
AD.
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
134, P. 111073 - 111073
Published: June 22, 2024
One
of
the
most
challenging
and
controversial
issues
in
microbiome
research
is
related
to
gut
microbial
metabolism
neuropsychological
disorders.
Psychobiotics
affect
human
behavior
central
nervous
system
processes
via
gut-brain
axis,
involving
neuronal,
immune,
metabolic
pathways.
They
have
therapeutic
potential
treatment
several
neurodegenerative
neurodevelopmental
disorders
such
as
depression,
anxiety,
autism,
attention
deficit
hyperactivity
disorder,
Alzheimer's
disease,
Parkinson's
schizophrenia,
Huntington's
anorexia
nervosa,
multiple
sclerosis.
However,
mechanisms
underlying
interaction
between
psychobiotics
abovementioned
diseases
need
further
exploration.
This
review
focuses
on
relationship
microbiota
its
impact
neurological
disorders,
examining
a
preventive
approach,
summarising
recent
axis
beneficial
effects
psychobiotics,
highlighting
for
investigation
this
area.
Foods,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2386 - 2386
Published: July 28, 2024
Fermented
foods
can
provide
many
benefits
to
our
health.
These
are
created
by
the
action
of
microorganisms
and
help
support
digestive
health
immune
system.
include
yogurt,
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 167 - 167
Published: Feb. 8, 2025
Background:
The
gut
microbiome
directly
impacts
brain
health
and
activity,
meaning
the
two
are
closely
associated.
This
relationship
suggests
a
link
between
microbial
imbalances
diseases
such
as
Alzheimer’s,
although
multiple
other
contributing
factors,
genetics,
also
play
part.
Additionally,
recent
studies
discovered
that
cerebrospinal
fluid
has
some
deoxyribonucleic
acid
(DNA),
which
can
be
interpreted
to
mean
exists
in
too.
vagus
nerve
central
nervous
immune
systems
responsible
for
connection
microbiome.
Aims
Objectives:
main
aim
of
this
systematic
review
is
analyze
existing
research
on
gut–brain
axis
fill
current
knowledge
gap.
Materials
Methods:
A
search
was
conducted
PubMed
database
based
set
predefined
MeSH
terms.
Results:
After
search,
2716
articles
meeting
parameters
were
found
PubMed.
list
then
downloaded
analyzed
according
inclusion/exclusion
criteria,
63
relevant
papers
selected.
Discussion:
Bacteria
produce
substances
considered
neuroactive.
These
compounds
or
indirectly
affect
function
through
axis.
However,
various
gaps
mechanisms
involved
need
addressed
first.
