Mitochondria: It is all about energy

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Language: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

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Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Feb. 1, 2023

Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.

Language: Английский

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The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions

Advanced Biology, Journal Year: 2023, Volume and Issue: 7(7)

Published: May 2, 2023

Abstract Certain metabolic interventions such as caloric restriction, fasting, exercise, and a ketogenic diet extend lifespan and/or health span. However, their benefits are limited connections to the underlying mechanisms of aging not fully clear. Here, these explored in terms tricarboxylic acid (TCA) cycle (Krebs cycle, citric cycle) suggest reasons for loss effectiveness ways overcoming it. Specifically, deplete acetate likely reduce conversion oxaloacetate aspartate, thereby inhibiting mammalian target rapamycin (mTOR) upregulating autophagy. Synthesis glutathione may provide high‐capacity sink amine groups, facilitating autophagy, prevent buildup alpha‐ketoglutarate, supporting stem cell maintenance. Metabolic also accumulation succinate, slowing DNA hypermethylation, repair double‐strand breaks, reducing inflammatory hypoxic signaling, lowering reliance on glycolysis. In part through mechanisms, decelerate aging, extending lifespan. Conversely, with overnutrition or oxidative stress, processes function reverse, accelerating impairing longevity. Progressive damage aconitase, inhibition succinate dehydrogenase, downregulation hypoxia‐inducible factor‐1 α , phosphoenolpyruvate carboxykinase (PEPCK) emerge potentially modifiable interventions.

Language: Английский

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Intermittent fasting: A promising dietary intervention for autoimmune diseases

Autoimmunity Reviews, Journal Year: 2023, Volume and Issue: 22(10), P. 103408 - 103408

Published: Aug. 11, 2023

Language: Английский

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Effect of Calorie Restriction and Intermittent Fasting Regimens on Brain-Derived Neurotrophic Factor Levels and Cognitive Function in Humans: A Systematic Review

Medicina, Journal Year: 2024, Volume and Issue: 60(1), P. 191 - 191

Published: Jan. 22, 2024

Background: The potential positive interaction between intermittent fasting (IF) and brain-derived neurotrophic factor (BDNF) on cognitive function has been widely discussed. This systematic review tried to assess the efficacy of interventions with different IF regimens BDNF levels their association functions in humans. Interventions forms such as caloric restriction (CR), alternate-day (ADF), time-restricted eating (TRE), Ramadan model (RIF) were targeted. Methods: A was conducted for experimental observational studies healthy people patients diseases published EMBASE, Scopus, PubMed, Google Scholar databases from January 2000 December 2023. We followed Preferred Reporting Items Systematic Reviews Meta-Analysis statements (PRISMA) writing this review. Results: Sixteen research works metabolic disorders met inclusion criteria Five showed a significant increase after intervention, while five reported decrease levels, other six no changes due regimens. Moreover, examined RIF protocol, which, three reduction, two along an improvement RIF. Conclusions: current findings suggest that varying effects healthy, overweight/obese individuals conditions. However, few human have shown increases controversial results. In humans, yet be fully investigated terms its long-term effect functions. Large-scale, well-controlled high-quality data are warranted elucidate impact

Language: Английский

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The effects of different intermittent fasting regimens in people with type 2 diabetes: a network meta-analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 25, 2024

Objective To compare the effects of four intermittent fasting regimens on blood glucose and insulin sensitivity in people with type 2 diabetes. Methods Randomized controlled trials treatment patients diabetes mellitus PubMed, Cochrane Library, Embase, ScienceDirect, Web Science, CNKI, VIP Database, WANFANG Database were searched for from library to September 2023. review authors independently screened studies extracted data. RevMan 5.4 was used direct comparison meta-results. Network meta-analysis performed using Stata16 software. Results 13 a total 867 included. The intervention twice-per-week fasting, fasting-mimicking diet, time-restricted eating, peridic better than that conventional diet. results network showed there no significant difference effect regimens. SUCRA ranking best comprehensive interventions improvement. Conclusion From perspective glucose, glycated hemoglobin resistance, has good effect, which can be as reference inter-type choose regimen. However, more clinical are needed verify this at later stage.

Language: Английский

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Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 327 - 327

Published: June 11, 2024

Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, intestinal microbiota dysbiosis, represent a pathological bridge between syndrome diabesity, cardiovascular, neurodegenerative disorders. This review aims to highlight some therapeutic strategies against involving integrative approaches improve lifestyle daily diet. The beneficial effects foods containing antioxidant polyphenols, control, physical activity were also considered. We comprehensively examined large body published articles basic, animal, human studie, well recent guidelines. As result, dietary polyphenols from natural plant-based antioxidants adherence Mediterranean diet, along with exercise, are promising complementary therapies delay or prevent onset counteract diabesity cardiovascular diseases, protect disorders cognitive decline. Modulation reduces risks associated MS, improves diabetes diseases (CVD), exerts neuroprotective action. Despite several studies, estimation polyphenol intake is inconclusive requires further evidence. Lifestyle interventions reduced calorie can outcomes.

Language: Английский

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Intermittent Fasting: Socio-Economic Profile of Spanish Citizens Who Practice It and the Influence of This Dietary Pattern on the Health and Lifestyle Habits of the Population

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2028 - 2028

Published: June 26, 2024

Intermittent fasting (IF) is a dietary approach that has gained popularity in recent years. More and more Spanish people are following this eating pattern, which consists of alternating periods with food intake. Its benefits include improved metabolic vascular health weight loss. Objectives: 1. To study the prevalence IF among population. 2. explore how demographic factors influence choice to adopt approach. Methods: A descriptive cross-sectional was conducted on population using NutSo-HH questionnaire, constructed, validated, disseminated by research team through non-probabilistic snowball sampling approach, collecting socio-demographic data nutritional, social lifestyle habits Results conclusions: valid sample 22,181 participated, whom 4.59% (n = 1018) said they practiced IF. The show middle-aged men than women practice In addition, individuals who follow methods less likely have no control over their intake, scared gain higher body image, but differences were found related unhealthy nights out. There also significant terms level education, income, size municipality, or region residence. conclusion, person practices seems adopted healthier habits.

Language: Английский

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Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 169 - 169

Published: Jan. 2, 2025

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women. Methods: Random allocation sixty-one participants into four groups: early plus (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 13.40 kg, 33.5 5.53 kg/m2), late (LTRE-PA, 30.60 7.94 94.45 15.36 34.37 7.09 only (LTRE, 27.93 9.79 88.32 10.36 32.71 5.15 kg/m2) control group (CG, 36.25 11.52 89.01 11.68 33.66 6.18 kg/m2). The intervention lasted for 12 weeks all groups. Both ETRE-PA LTRE-PA groups engaged rigorous aerobic resistance-training program. Results: Significant reductions body weight mass index were observed compared to CG LTRE post-intervention (p < 0.0005). Only exhibited significant decrease fat 0.02), low-density lipoprotein cholesterol 0.01), aspartate aminotransferase 0.002). alanine levels 0.004) 0.02) These two latter achieved higher performances 6-min walking test, bench press, 30-s squat, crunch vertical jump 0.0005 both), leg extension 0.02 both) when Conclusion: integration TRE PA leads greater improvements composition, lipid profile, performance, no differences between approaches. This strategy offers promising solution

Language: Английский

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