Morpho-Functional Analyses Demonstrate That Tyrosol Rescues Dexamethasone-Induced Muscle Atrophy DOI Creative Commons
Sara Salucci, Sabrina Burattini, Ilaria Versari

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2024, Volume and Issue: 9(3), P. 124 - 124

Published: July 17, 2024

Prolonged exposure to high dosages of dexamethasone, which is a synthetic glucocorticoid and well-known anti-inflammatory drug, may lead an increase in reactive oxygen species production, contributing muscle wasting. The prevention atrophy by ingestion functional foods attractive issue. In the last decade, natural antioxidant compounds have been increasingly investigated as promising molecules able counteract oxidative-stress-induced atrophy. Recently, we demonstrated properties two main olive oil polyphenols also known for their anticancer activities different cell models. Here, preventive effect tyrosol on dexamethasone-induced has means morpho-functional approaches C2C12 myotubes. Dexamethasone-treated cells showed reduced fiber size when compared control ones. While long confluent myotubes could be observed samples, those exposed dexamethasone appeared immature syncytia. Dysfunctional mitochondria accumulation autophagic vacuoles contributed myotube degeneration death. Tyrosol administration before treatment prevented wasting rescued mitochondrial lysosomal functionality. These findings demonstrate that attenuates damage, encourage use this molecule preclinical clinical studies synergy with other or physical activity aim prevent

Language: Английский

Oxidative stress: Roles in skeletal muscle atrophy DOI
Han Zhang,

Guangdong Qi,

Kexin Wang

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 214, P. 115664 - 115664

Published: June 16, 2023

Language: Английский

Citations

98
Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review DOI Creative Commons

Rodrigo Haber Mellen,

Otávio Simões Girotto,

Eduarda Boni Marques

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 136 - 136

Published: Jan. 5, 2023

Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have higher risk falls may be associated with heart disease, respiratory diseases, cognitive impairment, consequently an increased hospitalization, in addition causing economic impact high cost care during stay hospitals. The standardization appropriate treatment for patients sarcopenia that could help reduce pathology-related morbidity necessary. For these reasons, this study aimed perform systematic review role nutrition drugs ameliorate health quality life sarcopenic PRISMA guidelines were followed. Lifestyle interventions shown profound on but using supplements different can also skeletal maintenance. Creatine, leucine, branched-chain amino acids, omega 3, vitamin D show benefits. Although controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, dipeptidyl peptidase 4 inhibitors been considered alter sarcopenic's metabolic parameters, protect against cardiovascular diseases outcomes, while protecting muscles.

Language: Английский

Citations

47
Mediterranean Diet and Sarcopenia Features in Apparently Healthy Adults over 65 Years: A Systematic Review DOI Open Access
Sousana Κ. Papadopoulou, Paraskevi Detopoulou, Gavriela Voulgaridou

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1104 - 1104

Published: Feb. 22, 2023

Low muscle mass combined with changes in physical function and quality is defined as sarcopenia. In people > 60 years, sarcopenia reaches 10% tends to increase age. Individual nutrients, such protein, may have a protective role against sarcopenia, but recent evidence suggests that protein alone has been ineffective increasing strength. Dietary patterns, instead, high "anti-inflammatory" potential, the Mediterranean dietary pattern, considered an emerging remedy The aim of this systematic review was summarize diet prevention and/or improvement, including data, healthy elders. We searched published studies about until December 2022 Pubmed, Cochrane, Scopus search engine grey literature. total, ten articles were identified relevant: four cross-sectional six prospective. No clinical trial identified. Only three assessed presence measured mass, which essential criterion diagnosis. adherence had, general, positive function, while results less clear regard Additionally, there no effect on There need for conduction trials order reach cause-effects conclusions regarding importance management non-Mediterranean populations.

Language: Английский

Citations

44
Low Adherence to Mediterranean Diet Is Associated with Probable Sarcopenia in Community-Dwelling Older Adults: Results from the Longevity Check-Up (Lookup) 7+ Project DOI Open Access
Stefano Cacciatore, Riccardo Calvani, Emanuele Marzetti

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1026 - 1026

Published: Feb. 18, 2023

Muscle strength is a relevant metric of aging. Greater adherence to Mediterranean diet associated with better health outcomes across all life stages; however, evidence on the relationship between and muscle in older adults inconclusive. In this study, we evaluated handgrip large sample community-dwelling from Longevity Check-up 7+ project. A total 2963 participants (mean age 72.8 ± 5.7 years; 54.4% women) were analyzed. was using modified Medi-Lite score categorized as low (≤8), good (9 11), or high (≥12). Handgrip normal according cut-points by European Working Group Sarcopenia Older People 2. lower had significantly higher prevalence probable sarcopenia (25.9%) than those (19.1%) (15.5%) adherence. The proportion increased age, but it remained groups. Logistic regression showed that greater risk sarcopenia. female sex, physical inactivity Our findings emphasize positive association healthy lifestyles, including diet, function old age.

Language: Английский

Citations

39
The Influence of the Mediterranean Dietary Pattern on Osteoporosis and Sarcopenia DOI Open Access
María Carmen Andreo-López, Victoria Contreras-Bolívar, Beatriz García-Fontana

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3224 - 3224

Published: July 20, 2023

Diet is a modifiable factor in bone and muscle health. The Mediterranean diet (MedDiet) rich nutrients contains key bioactive components with probable protective effects on deterioration. Osteoporosis (OP) sarcopenia are diseases that increase frailty susceptibility to fracture, morbidity mortality. Therefore, it necessary combat them the population. In this regard, MedDiet adherence has proven be beneficial mineral density (BMD), mass, physical function, OP sarcopenia. Hence, proposed as therapeutic tool could slow onset of osteoporosis However, there doubt about interaction between MedDiet, strength fracture risk. Perhaps amount EVOO (extra virgin olive oil), fruits, vegetables fish anti-inflammatory antioxidant ingested an influence, though results remain controversial.

Language: Английский

Citations

26
Natural Compounds for Preventing Age-Related Diseases and Cancers DOI Open Access
Mi‐Ran Ki,

Sol Youn,

Dong Hyun Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

Citations

9
Impact of a Very Low-Calorie Ketogenic Diet (VLCKD) on Changes in Handgrip Strength in Women with Obesity DOI Open Access
Luigi Barrea, Giulia de Alteriis, Giovanna Muscogiuri

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 4213 - 4213

Published: Oct. 10, 2022

The preservation of muscle mass, which is positively associated with strength, has been included among the benefits ketogenic diets due to synergistic effects exerted by reduction in visceral adipose tissue and obesity-related pro-inflammatory status. handgrip strength (HGS) test widely used as a single indicator represent overall strength. possible association changes HGS patients obesity during consumption very low-calorie diet (VLCKD) not yet investigated. aim this prospective study was assess efficacy VLCKD on promoting high-sensitivity C-reactive protein (hs-CRP) levels, serological marker obesity-related, low-grade inflammation, population women after 45 days active phase VLCKD. This pilot, uncontrolled, single-center, open-label clinical trial examined 247 Caucasian women, aged 18−51 years (body mass index, BMI: 30.0−50.9 kg/m2) who were consecutively enrolled following Anthropometric measures physical activity evaluated. Muscle measured using grip dynamometer. Body composition evaluated bioelectrical impedance analysis (BIA) phase-sensitive system. hs-CRP levels determined nephelometric assay. Adherence VLCKD, ketosis status, checked weekly phone call. At day 45, BMI, fat (FM), significantly decreased (∆-7.5 ± 3.1%, ∆-15.6 9.0%, ∆-39.9 44.6%; respectively; p < 0.001 for all three parameters), while had increased (∆+17.4 13.2%; 0.001). After adjusting ∆BMI, ∆waist circumference, ∆hs-CRP activity, correlation ∆HGS (kg), ∆FM ∆ free (FFM) (kg) remained statistically significant (r = −0.331, r 0.362, Interestingly, between −0.288, 0.001) ∆FFM 0.395, also independent percentage weight loss. We are first report that, along body an improvement inflammatory adjustment common confounding variables.

Language: Английский

Citations

32
Exploring the impact of beliefs and experiential factors on extra virgin olive oil consumption DOI Creative Commons

Filippo Sgroi,

Caterina Sciortino, Giusi Giamporcaro

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 15, P. 101056 - 101056

Published: Feb. 19, 2024

Language: Английский

Citations

6
Unraveling the Extra Virgin Olive Oil Effect on Inflammation and on Gut and Saliva Microbiota DOI Creative Commons
Marta Correia, Ana T. P. C. Gomes, Inês Moreira

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 338 - 338

Published: Feb. 26, 2025

Extra virgin olive oil (EVOO) with a high content of polyphenols has attracted attention due to its proved beneficial effects in decreasing the risk cardiovascular disease, modulating cholesterol levels (HDL and LDL), inflammatory markers, haemoglobin1Ac, suggesting that EVOO can have an impact glycemia regulation. This study assessed consumption northern Portuguese polyphenol-rich profile bioactive molecules on several parameters, such as saliva serum biomarkers, explored gut oral microbiota regarding Bacillota Bacteroidota content. Thus, glycated haemoglobin (HbA1c), low-density lipoprotein (LDL-C), C-reactive protein (CRP), faecal salivary microbiomes were evaluated before after exposure EVOO. The results showed promotes decrease HbA1C pro-inflammatory interleukin IL-1β, associated processes. Moreover, intake modulated microbiota, increasing both ecological niches phyla being health, demonstrating prebiotic effect.

Language: Английский

Citations

0
Functional Foods, a Hope to Delay Muscle Dystrophy Progression: A Potential Role for Omega Fatty Acids DOI Open Access
Ilaria Versari, Alberto Bavelloni, Mirko Traversari

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1039 - 1039

Published: March 15, 2025

Functional foods, thanks to their basic nutritional properties, can have physiological benefits and alleviate the symptoms of many chronic diseases. They contain active components deriving either from plant or animal sources, they show anti-inflammatory, cardiotonic, antioxidant pharmacological activities that could be useful in preventing oxidative damage inflammatory processes a variety disorders. There is evidence vitro, vivo, clinical observational studies some compounds significant effects modulating muscular dystrophy phenotype, which characterized by fibrosis, myofiber necrotic cell death, inflammation, stress, dysfunctional mitochondria. This review involves collecting data main medical databases detailing key features involved progression relevance fatty-acid as diet supplements management disease. Omega fatty acids improve dystrophic phenotype terms fibrosis inflammation reduction, stimulating mitochondrial activity systems. play crucial role food supplementation delay progression. overview appears extremely relevant for researchers who are studying these molecules valid alternatives glucocorticoids, today remain only recognized cure patients.

Language: Английский

Citations

0