Association between dietary index of gut microbiota and constipation in a female population: a cross-sectional study DOI Creative Commons

Wangfeng Lu,

Gang Feng, Lei Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Objective To examine the potential association between dietary index of gut microbiota (DI-GM) scores and constipation in adult women United States. Methods This cross-sectional study used data from participants 2005–2010 US National Health Survey (NHANES). The missing values covariables were filled by multiple interpolation. Multivariate logistic regression models to determine odds ratios (OR) 95% confidence intervals (CI) for DI-GM constipation. Subgroup analyses also performed possible interactions Results Of 7,325 subjects, 887 reported constipations, with a prevalence 12.1%. After adjustment multivariate modeling, score was significantly associated (0.92 [95% CI 0.87–0.96]; p = 0.001). Similar results found beneficial (OR 0.89 0.84 0.95]; 0. 001). revealed that relationship remained stable ( > 0.05). Conclusion negatively incidence female population. Clinicians should consider influence structure on treatment women. Dietary intervention can be an important strategy comprehensive

Language: Английский

Characteristics of the Gut Microbiome and Serum Metabolome in Patients with Functional Constipation DOI Open Access
Jialiang Wang, Linlin Wang,

Qiangqing Yu

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1779 - 1779

Published: April 6, 2023

Functional constipation (FC) is a gastrointestinal disorder with high incidence, and it seriously affects patients' physical mental health. Several studies have shown that the gut microbiome associated FC, but these produced inconsistent findings, few reflecting relationship between metabolites. This study used 16S rRNA microbial genomics non-target metabolome based on liquid chromatography-mass spectrometry to analyze microbiota composition serum metabolic profiles of 30 FC patients 28 healthy individuals. We found individuals different structures profiles. had more Bacteroides butyrate-producing bacteria (Roseburia, Faecaliberium, Butyriccoccus). The upstream products host arginine biosynthesis (2-oxoglutaric acid, L-glutamic N-acetylornithine, L-ornithine) were significantly reduced in In summary, our describes functional constipation. It reveals may be increased Bacteroidetes downregulation biosynthesis, which potential markers for diagnosing

Language: Английский

Citations

24
Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism DOI

Tianchi Duan,

Xiaoyuan Wang,

Xinyue Dong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(44), P. 16568 - 16580

Published: Oct. 24, 2023

Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency side effects. Here, we demonstrated that broccoli-derived exosome-like nanoparticles (BENs), natural product with high stability, ameliorated LOP-induced in mice. Specifically, orally administered BENs (17.5 mg/kg/d) effectively shortened defecation time, sped up intestinal propulsion rate, increased feces amount constipated also raised excitatory neurotransmitters SP MTL reduced inhibitory VIP ET-1. Mechanistically, were taken by gut microbes, restored LOP-disordered microbiota, altered microbial metabolism of SCFAs tryptophan, as evidenced the results fluorescence microscopy, 16S rRNA gene sequencing, nontargeted metabolomics. Thereinto, BEN-enriched SCFA-producing microorganisms are closely associated levels BEN-elevated indole-3-pyruvic acid 3-indoleacetic highly linked ET-1, SP, levels. Conclusively, BENs, mitigating regulating microbiota tryptophan metabolism, showed potential be developed alternative regimens for constipation.

Language: Английский

Citations

24
Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities DOI
Matthias Van Hul, Audrey M. Neyrinck, Amandine Everard

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(3)

Published: June 28, 2024

SUMMARY The gut microbiota is a major factor contributing to the regulation of energy homeostasis and has been linked both excessive body weight accumulation fat mass (i.e., overweight, obesity) or loss, weakness, muscle atrophy, depletion cachexia). These syndromes are characterized by multiple metabolic dysfunctions including abnormal food reward intake, storage, low-grade inflammation. Given increasing worldwide prevalence obesity, cachexia, associated disorders, novel therapeutic strategies needed. Among different mechanisms explaining how capable influencing host metabolism balance, numerous studies have investigated complex interactions existing between nutrition, microbes, their metabolites. In this review, we discuss microbes microbiota-derived metabolites regulate metabolism. We describe role barrier function in onset inflammation context. explore importance gut-to-brain axis glucose but also key played liver. Finally, present specific examples using targeted approaches such as prebiotics probiotics might affect metabolites, signaling pathways, with reflect on challenges move from bench bedside.

Language: Английский

Citations

15
Modelling host–microbiome interactions in organ-on-a-chip platforms DOI
Yong Cheol Shin, Nam Than, So‐Youn Min

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(2), P. 175 - 191

Published: Nov. 17, 2023

Language: Английский

Citations

19
Dynamics of the Gut Microbiota and Faecal and Serum Metabolomes during Pregnancy—A Longitudinal Study DOI Open Access

Ruili Pan,

Min Guo, Ying Chen

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 483 - 483

Published: Feb. 7, 2024

Normal pregnancy involves numerous physiological changes, including changes in hormone levels, immune responses, and metabolism. Although several studies have shown that the gut microbiota may an important role progression of pregnancy, these findings been inconsistent, relationship between metabolites change dynamically during after remains to be clarified. In this longitudinal study, we comprehensively profiled temporal dynamics microbiota,

Language: Английский

Citations

7
Association between dietary copper intake and constipation in US adults DOI Creative Commons
Wenyi Du, Yan Chen,

Yinkang Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Dietary micronutrients are integral to the development and progression of constipation; however, specific relationship between dietary copper intake constipation has not been thoroughly investigated. This study aims examine correlation among U.S. adults, thereby offering novel insights recommendations for clinical management prevention constipation. Bowel health data from National Health Nutrition Examination Survey (NHANES) conducted 2005 2010 were analyzed. Subjects' information was collected through questionnaire records. Multivariate logistic regression analysis, subgroup curve fitting analysis used assess chronic After adjusting all possible confounders, each unit increase in (converted natural logarithms) associated with a 20% reduction prevalence (OR = 0.80; 95% CI 0.65-0.98; P 0.037). The interaction P-values subgroups greater than 0.05, indicating that findings stable consistent across subgroups. present showed significant negative association adults. finding raises healthcare professionals' awareness impact trace elements on intestinal important implications personalized meal plans rational supplementation patients

Language: Английский

Citations

6
Association between dietary vitamin E intake and constipation: NHANES 2005–2010 DOI Creative Commons

Junfeng Cai,

Danqing Li,

Rui-Jun Xie

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 20, 2024

This investigation aimed to analyze the association between dietary vitamin E intake and constipation prevalence among United States adults.

Language: Английский

Citations

6
Probiotics alleviate constipation and inflammation in late gestating and lactating sows DOI Creative Commons
Teng Ma, Weiqiang Huang, Yalin Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 23, 2023

Constipation and systemic inflammation are common in late pregnant lactating sows, which cause health problems like uteritis, mastitis, dystocia, or even stillbirth, further influencing piglets' survival growth. Probiotic supplementation can improve such issues, but the beneficial mechanism of relieving constipation enhancing gut motility remains underexplored. This study aimed to investigate effects probiotic drinking water sows on constipation, inflammation, growth performance. Seventy-four were randomly allocated (n = 36) control 38) groups. treatment significantly relieved sow enhanced serum IL-4 IL-10 levels while reducing IL-1β, IL-12p40, TNF-α levels, increased piglet daily gain weaning weight. Furthermore, administration reshaped bacteriome phageome structure/diversity, accompanied by increases some potentially bacteria. At 113 days gestation, group was enriched several microbial bioactive metabolites, multiple carbohydrate-active enzymes that degrade pectin starch, fecal butyrate acetate, metabolites involved vitamin amino acid metabolism. Our integrated correlation network analysis revealed alleviation associated with changes bacteriome, phageome, metabolic potential,

Language: Английский

Citations

13
Probiotics for functional constipation in children: an overview of overlapping systematic reviews DOI Creative Commons
Yunxin Zhang, Aiping Li, Jing Qiu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 8, 2024

Background This overview of systematic reviews (SRs) and meta-analysis (MAs) aimed to systematically collate, appraise synthesize evidence probiotics for functional constipation (FC) in children. Methods SRs/MAs FC children were identified by searching Cochrane Library, PubMed, Embase, Web science. Assessment Multiple Systematic Reviews 2 (AMSTAR-2), Preferred Reporting Items Meta-Analyses (PRISMA), Grading Recommendations, Assessment, Development, Evaluation (GRADE) unitized two reviewers independently assess the methodological quality, reporting quality evidence, respectively. Results Seven met eligibility criteria included this study. According AMSTAR-2, a very low assessment was given due limitations items 2, 4 7. For PRISMA statement, overall unsatisfactory lack on protocol, risk bias across studies, synthesis results, additional analysis. GRADE, outcomes rated as moderate. Conclusions Probiotics may be beneficial improving Because inconsistent conclusions, further rigorous, normative comprehensive are needed provide robust definitive conclusions.

Language: Английский

Citations

4
Altered gut microbial profile is associated with differentially expressed fecal microRNAs in patients with functional constipation DOI Creative Commons
Junpeng Yao, Xiangyun Yan, Yanqiu Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

While dysbiosis within the intestinal ecosystem has been associated with functional constipation (FC), mechanisms underlying interactions between FC and microbiome remain poorly elucidated. Recent investigations suggested that host microRNAs (miRNAs) can modulate bacterial growth influence composition of gut microbiome. To explore connection microbiota fecal miRNAs in patients, we initially employed 16S rRNA sequencing to assess microbial landscape 30 patients healthy controls (HCs). The α-diversity group exhibited some alterations, β-diversity significantly differed, signifying distinctive variations HCs. Subsequently, identified 44 differentially expressed (DE) feces from Through correlation analysis DE FC-associated microbiota, detected an interaction involving nine ( miR-205-5p , miR-493-5p miR-215-5p miR-184 miR-378c miR-335-5p miR-514a-3p miR-141-3p miR-34c-5p ) seven genera Oscillibacter Escherichia.Shigella UCG.002 Lachnospiraceae_NK4A136_group Lachnospiraceae_UCG.010 Eubacterium_ruminantium_group Megamonas ), as evidenced by a co-occurrence network. Further, comprehensive panel diagnostic biomarkers demonstrated robust discriminatory capacity predicting status when integrated into random forest model (AUC = 0.832, 95% CI: 65.73–98.88). Microbiomes correlating enrichment distinct predicted metabolic categories. Moreover, correlated bacteria were found be enriched signaling pathways linked colonic contractility, including Axon guidance, PI3K-Akt pathway, MAPK Hippo pathway. Our study offers insight global relationship context FC, presenting potential targets for further experimental validation therapeutic interventions.

Language: Английский

Citations

4