The influence of the gut microbiome on ovarian aging

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 3, 2024

Ovarian aging occurs prior to the of other organ systems and acts as pacemaker process multiple organs. As life expectancy has increased, preventing ovarian become an essential goal for promoting extended reproductive function improving bone genitourinary conditions related in women. An improved understanding may ultimately provide tools prediction mitigation this process. Recent studies have suggested a connection between gut microbiota, alterations composition functional profile microbiota profound consequences on function. The interaction ovaries is bidirectional. In review, we examine current knowledge ovary-gut crosstalk further discuss potential role anti-aging interventions. Microbiota-based manipulation appealing approach that offer new therapeutic strategies delay or reverse aging.

Language: Английский

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A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Female infertility is a multifactorial condition influenced by various genetic, environmental, and lifestyle factors. Recent research has investigated the significant impact of gut microbiome dysbiosis on systemic inflammation, metabolic dysfunction, hormonal imbalances, which can potentially impair fertility. The gut-brain axis, bidirectional communication system between brain, also plays role in regulating reproductive functions. Emerging evidence suggests that influence brain functions behavior, further emphasizing importance microbiota-gut-brain axis reproduction. Given their as major modulator microbiome, diet dietary factors, including patterns nutrient intake, have been implicated development management female infertility. Hence, this review aims to highlight patterns, such Western (WD) Mediterranean (MD), decipher modulatory action infertile women. By contrasting detrimental effects WD with therapeutic potential MD, we emphasize pivotal balanced rich nutrients promoting healthy microbiome. These insights underscore targeted interventions modifications promising strategies enhance outcomes subfertile

Language: Английский

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Effect of High Fat Diet on Disease Development of Polycystic Ovary Syndrome and Lifestyle Intervention Strategies

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2230 - 2230

Published: May 8, 2023

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects premenopausal women. The etiology of PCOS multifaceted, involving various genetic epigenetic factors, hypothalamic–pituitary–ovarian dysfunction, androgen excess, insulin resistance, adipose-related mechanisms. High-fat diets (HFDs) has been linked to the development disorders weight gain, exacerbating obesity impairing function axis. This results in increased hyperinsulinemia, release inflammatory adipokines, leading heightened fat synthesis reduced breakdown, thereby worsening reproductive consequences PCOS. Effective management requires lifestyle interventions such as dietary modifications, loss, physical activity, psychological well-being, well medical or surgical some cases. article systematically examines pathological basis influence HFDs on its development, with aim raising awareness connection between diet health, providing robust approach interventions, serving reference for targeted drug treatments.

Language: Английский

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Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1629 - 1629

Published: May 26, 2024

Understanding the intricate relationship between nutrition, hormonal balance, and gender-specific factors is crucial for developing targeted interventions to mitigate obesity-related endocrine disruptions improve metabolic health. This narrative review examines impact of various dietary patterns on regulation in both men women, focusing their effects balance health context obesity. Calorie restriction, Western diet, high-fat diets, low-CHO plant-based Mediterranean diet are analyzed relation influence Future research directions include investigating specific mechanisms underlying influences regulation, addressing differences body fat distribution, exploring needs individuals undergoing gender transition. Personalized tailored individual profiles essential optimizing outcomes across spectrum. By integrating considerations into recommendations, healthcare professionals can better support achieving optimal balance.

Language: Английский

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Exploring Maternal Diet-Epigenetic-Gut Microbiome Crosstalk as an Intervention Strategy to Counter Early Obesity Programming

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4358 - 4378

Published: May 6, 2024

Alterations in a mother’s metabolism and endocrine system, due to unbalanced nutrition, may increase the risk of both metabolic non-metabolic disorders offspring’s childhood adulthood. The obesity offspring can be determined by interplay between maternal nutrition lifestyle, intrauterine environment, epigenetic modifications, early postnatal factors. Several studies have indicated that fetal bowel begins colonize before birth that, during nursing, gut microbiota continues change. is primarily transferred fetus through environment. In this way, it able impact establishment neonatal microbiome, resulting signatures possibly predispose development later life. However, antioxidants exercise mother been shown improve metabolism, with improvements leptin, triglycerides, adiponectin, insulin resistance, as well weight mechanisms. Therefore, extensive literature review, we aimed investigate relationship diet, epigenetics, order expand on current knowledge identify novel potential preventative strategies for lowering children adults.

Language: Английский

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Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12166 - 12166

Published: Nov. 13, 2024

The widespread use of plastics has increased environmental pollution by micro- and nanoplastics (MNPs), especially polystyrene (PS-MNPs). These particles are persistent, bioaccumulative, linked to endocrine-disrupting toxicity, posing risks reproductive health. This review examines the effects PS-MNPs on mammalian systems, focusing oxidative stress, inflammation, hormonal imbalances. A comprehensive search in Web Science Core Collection, following PRISMA 2020 guidelines, identified studies impact fertility, including oogenesis, spermatogenesis, folliculogenesis. An analysis 194 publications revealed significant harm, such as reduced ovarian size, depleted follicular reserves, apoptosis somatic cells, disrupted estrous cycles females, along with impaired sperm quality imbalances males. were endocrine disruption, leading cellular molecular damage. Further research is urgently needed understand toxicity mechanisms, develop interventions, assess long-term health impacts across generations, highlighting need address these challenges given growing exposure.

Language: Английский

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Molecular docking and in vivo protective effects of okra (Abelmoschus esculentus) against metabolic dysfunction in high-fat, high-sodium diet-fed rats

Food & Function, Journal Year: 2024, Volume and Issue: 15(7), P. 3566 - 3582

Published: Jan. 1, 2024

Okra mucilage and flesh seem to be promising candidates for protection against metabolic dysfunction. significantly reduced CRP, TNF-α, IL-6, urine calcium levels while increasing feces lipid femur levels.

Language: Английский

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Nutritional and exercise interventions to improve conception in women suffering from obesity and distinct nosological entities

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 28, 2024

Infertility among women, particularly those living with obesity, presents a multifaceted challenge implications for reproductive health worldwide. Lifestyle interventions, mainly focusing on weight loss, have emerged as promising strategies to improve fertility outcomes in this population. This review aims explore the effectiveness of various lifestyle encompassing dietary modifications and exercise regimens, enhancing women obesity associated conditions such polycystic ovary syndrome, congenital adrenal hyperplasia, type 2 diabetes mellitus, premenopause, hypothyroidism eating disorders. Methodology study search encompass broad spectrum, ranging from interventions targeting management through slow or rapid loss approaches emphasizing whole food groups, specific nutrients, patterns like low-carbohydrate ketogenic diets, well Mediterranean diet. By synthesizing existing findings recommendations, contributes understanding addressing infertility, an emphasis population age excess known unknown infertility issues, while promoting their integration into clinical practice optimize overall well-being.

Language: Английский

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Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Introduction A long-term high-fat diet (HFD) cause obesity and infertility through hypothalamic inflammation insulin resistance, leading to metabolic abnormalities ovulation dysfunction. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a treatment for type diabetic patients, regulating adipose tissue metabolism, inflammation, in women with polycystic ovary syndrome (PCOS). study aimed investigate the pharmacological effects of dapagliflozin on improving energy sex hormones, fertility female mice following prolonged consumption HFD. Methods At 6 weeks age, were fed HFD treated dapagliflozin. Serum hormone concentrations inflammatory factors aged 28 or 38 quantified using ultrasensitive enzyme-linked immunosorbent assays (ELISAs). Metabolic parameters also assessed documented at different stages experiment. 34 half experimental each four groups standard chow mated male mice. Pregnancy rate, abortion pregnancy-related deaths, perinatal outcomes systematically recorded. Results After 16 feeding, significantly attenuated visceral fat deposition, weight gain, glucose intolerance, resistance induced by diet. However, these diminished after 32 weeks. Unexpectedly, neither nor elicited any significant changes serum IL-6 TNFα levels. Throughout experiment period, exhibited favorable reproductive function along sensitivity luteinizing (LH) release from pituitary gland. Discussion In conclusion, this demonstrates that alleviated HFD-induced dysfunction independently obesity, peripheral systemic suggesting its potential promising diet-related disorders.

Language: Английский

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Single-cell RNA sequencing reveals the effects of high-fat diet on oocyte and early embryo development in female mice

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 20, 2024

Obesity is a global health issue with detrimental effects on various human organs, including the reproductive system. Observational data and several lines of animal experimental suggest that maternal obesity impairs ovarian function early embryo development, but precise pathogenesis remains unclear.

Language: Английский

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