The Intriguing Connection Between the Gut and Lung Microbiomes DOI Creative Commons
Magdalena Druszczyńska, Beata Sadowska,

Jakub Kulesza

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 1005 - 1005

Published: Nov. 15, 2024

Recent advances in microbiome research have uncovered a dynamic and complex connection between the gut lungs, known as gut-lung axis. This bidirectional communication network plays critical role modulating immune responses maintaining respiratory health. Mediated by interactions, metabolic byproducts, microbial communities both organs, this axis demonstrates how gut-derived signals, such metabolites modulators, can reach lung tissue via systemic circulation, influencing function disease susceptibility. To explore implications of connection, we conducted systematic review studies published 2001 2024 (with much nearly 60% covering period 2020-2024), using keywords "gut-lung axis", "microbiome", "respiratory disease", "immune signaling". Studies were selected based on their relevance to mechanisms, impact dysbiosis, microbiota diseases. provides comprehensive overview axis, emphasizing its importance regulating inflammatory linked Understanding intricate pathway opens new avenues for microbiota-targeted therapeutic strategies, which could offer promising interventions diseases like asthma, chronic obstructive pulmonary disease, even infections. The insights gained through underscore potential novel target preventative approaches medicine, with enhancing

Language: Английский

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies DOI
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma

et al.

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

Citations

75
Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation DOI Creative Commons
Carlos A. Labarrere, Ghassan S. Kassab

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 1, 2022

Many local and systemic diseases especially that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease stroke, cancer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing 19 (COVID-19), involve both, (1) oxidative stress excessive production reactive oxygen species (ROS) lower glutathione (GSH) levels, (2) inflammation. The GSH tripeptide (γ- L-glutamyl-L-cysteinyl-glycine), the most abundant water-soluble non-protein thiol in cell (1–10 mM) is fundamental for life by (a) sustaining adequate redox signaling needed to maintain physiologic levels control processes, (b) limiting tissue damage. activity facilitated activation Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related (Nrf2)-antioxidant response element (ARE) regulator pathway, releasing Nrf2 regulates expression genes controlling antioxidant, inflammatory immune system responses. exists thiol-reduced (>98% total GSH) disulfide-oxidized (GSSG) forms, concentrations GSSG their molar ratio indicators functionality cell. depletion may play a central role COVID-19 pathophysiology, host severity mortality. Therapies enhancing could become cornerstone reduce fatal outcomes increasing prevent subdue these diseases. value makes paramount research field biology medicine be key against inflammation SARS-CoV-2 infection disease. In this review, we emphasize on as risk (ischemic stroke), importance antioxidants (3) significance counteract persistent damaging inflammation, inflammaging early (premature) associated damage caused lack antioxidant defenses younger individuals, (4) new therapies include restoration.

Language: Английский

Citations

70
Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis DOI
Ankita Goyal, Vishal Chopra, Kranti Garg

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Physical activity and chronic obstructive pulmonary disease: a scoping review DOI Creative Commons
Xinyue Xiang, Lihua Huang, Yong Fang

et al.

BMC Pulmonary Medicine, Journal Year: 2022, Volume and Issue: 22(1)

Published: Aug. 5, 2022

Abstract Background Reduced physical activity (PA) was the strongest predictor of all-cause mortality in patients with chronic obstructive pulmonary disease (COPD). This scoping review aimed to map evidence on current landscape activity, barriers and facilitators, assessment tools across COPD patients. Methods Arksey O’Malley’s methodology framework guided conduct this review. An electronic search conducted five English databases (PubMed, Cochrane Library, PsycINFO, CINAHL Web Science) three Chinese (CNKI, CQVIP WAN-FANG) January 2022. Two authors independently screened literature, extracted studies characteristics. Results The initial yielded 4389 results, which 1954 were duplicates. Of remaining 135 articles, 42 met inclusion criteria. Among reviewed there 14 (33.3%) cross-sectional study, 9 (21.4%) cohort 4 (9.5%) longitudinal 3 qualitative 12 (28.7%) randomized control trials. main identified older age, women, lung function, comorbidities, symptoms (fear breathlessness injury, severe fatigue, anxiety depression), GOLD stage, frequency exacerbation, oxygen use, lack motivation environment-related (e.g., season weather). Twelve have evaluated effects exercise walking training, rehabilitation (PR), pedometer, self-efficacy enhancing intervention behavioral modification intervention) PA showed significant positive prognosis However, real life it is difficult maintain people COPD. Conclusions Changing behavior requires multidisciplinary collaboration. Future need identify best instruments measure clinical practice. should focus different types, time intensity randomized, adequately-powered, controlled trials evaluate long-term effectiveness change interventions PA.

Language: Английский

Citations

40
Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment DOI Creative Commons
Binay Kumar Shah, Bivek Singh, Y Wang

et al.

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 15

Published: July 6, 2023

Most patients diagnosed with chronic obstructive pulmonary disease (COPD) present hallmark features of airway mucus hypersecretion, including cough and expectoration. Airway function as a native immune system the lung that severs to trap particulate matter pathogens allows them clear from via ciliary transport. Chronic hypersecretion (CMH) is main factor contributing increased risk morbidity mortality in specific subsets COPD patients. It is, therefore, primarily important develop medications suppress hypersecretions these Although there have been some advances treatment, more work remains be done better understand mechanism underlying seek effective treatments. This review article discusses structure significance lungs focusing on gel-forming mucins impacts CMH lungs. Furthermore, we summarize pharmacological nonpharmacological treatments well novel interventional procedures control

Language: Английский

Citations

21
Nanocarrier-Based Approaches to Combat Chronic Obstructive Pulmonary Disease DOI
Tarun Virmani, Girish Kumar, Reshu Virmani

et al.

Nanomedicine, Journal Year: 2022, Volume and Issue: 17(24), P. 1833 - 1854

Published: July 20, 2022

Abnormalities in airway mucus lead to chronic disorders the pulmonary system such as asthma, fibrosis and obstructive disease (COPD). Among these, COPD is more prominent worldwide. Various conventional approaches are available market for treatment of COPD, but delivery drugs target site remains a challenge with approaches. Nanocarrier-based considered best due their sustained release properties site, smaller size, high surface-to-volume ratio, patient compliance, overcoming defenses improved pharmacotherapy. This article provides updated information about along nanocarrier-based well potential gene therapy stem cell combat COPD.

Language: Английский

Citations

24
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis DOI Creative Commons
Yue Dong, Ying Dong, Chengyue Zhu

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 17, 2024

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms airflow limitation. The involvement C-C motif chemokine ligand 2 (CCL2) in COPD pathogenesis, particularly macrophage regulation activation, is poorly understood despite its recognized role chronic inflammation. Our study aims to elucidate the regulatory molecular mechanisms CCL2 pathogenesis COPD, providing new insights for therapeutic strategies.

Language: Английский

Citations

5
Therapeutic effect of phycocyanin on chronic obstructive pulmonary disease in mice DOI Creative Commons
Wenjun Li, Yuanyuan Li, Qi Wang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 66, P. 285 - 301

Published: Jan. 10, 2024

The prevention and treatment of chronic obstructive pulmonary disease (COPD) is closely tied to anti-oxidation anti-inflammation. Phycocyanin (PC) have numerous pharmacological effects such as anti-oxidation, anti-inflammation, so on. But it remains unclear whether PC can play a therapeutic role in COPD. As inflammation oxidative stress aggravate the COPD, this study explore effect on COPD mice its mechanisms. model was established by exposing lipopolysaccharide (LPS) cigarette smoke (CS), administrated concentration 50 mg/kg for 30 days. On last day, lung function measured, bronchoalveolar lavage fluid (BALF) obtained classified cell. Lung tissues pathological change analyzed organ indices statistics were measured. Based molecular docking mechanism explored with Western blotting, immunohistochemical immunofluorescence vivo vitro. significantly ameliorated reduced (p<0.05), Hematoxylin eosin (H&E) showed depressed inflammatory cell accumulation emphysema. Periodic acid Schiff (PAS) Masson staining revealed that retarded goblet cells metaplasia collagen deposition (p<0.05). In addition, regulated Heme oxygenase 1 (HO-1) (p<0.05) NAD(P)H dehydrogenase quinone (NQO1) level (p<0.01) lung, well NOX2 macrophages. Molecular results indicate phycocyanobilin (PCB) had good binding site Keap1 proteins, phycocyanobilin-bound phycocyanin peptide (PCB-PC-peptide) further studies. vitro PCB-PC-peptide could depress phospho-NF-E2-related factor 2 (p-Nrf2) NQO1 protein expression RAW264.7 induced extract (CSE) exerts beneficial via anti-inflammatory anti-oxidative stress, which may be achieved through PCB.

Language: Английский

Citations

4
Mucus production and chronic obstructive pulmonary disease, a possible treatment target: zooming in on N-acetylcysteine DOI Creative Commons
Federico Baraldi, Tommaso Bigoni, Maria Pia Foschino Barbaro

et al.

Monaldi Archives for Chest Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Mucus hypersecretion is a trait of chronic obstructive pulmonary disease (COPD) associated with poorer outcomes. As it may be present before airway obstruction, its early treatment have preventive role. This narrative review the literature presents role mucus dysfunction in COPD, pathophysiology, and rationale for use N-acetylcysteine (NAC). NAC can modify rheology, improving clearance reducing damage induced MUC5AC expression. It exerts direct indirect (glutathione replenishment) antioxidant mechanism; interferes inflammatory molecular pathways, including inhibition nuclear factor-kB activation epithelial cells reduction expression cytokine tumor necrosis factor α, interleukin (IL)-6, IL-10. Some clinical experiences suggest that adjunctive reduce symptoms improve outcomes patients COPD. In conclusion, candidate drug subjects at risk COPD development.

Language: Английский

Citations

0
Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development DOI Creative Commons
Evalyne M. Jansen, Luke van der Koog,

Robin A.B. Elferink

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with a significant impact on low‐ and middle‐income countries, making it critical challenge for global health equity sustainable development goals. Extracellular vesicles (EVs) are emerging as promising treatment COPD, but conventional storage at −80 °C limits their accessibility. This study explores alternative methods to enhance EV stability accessibility, particularly in low‐resource settings. EVs from lung fibroblasts subjected freezing, freeze drying, spray drying inulin or mannitol. The biophysical properties evaluated by capacity support organoid formation. Inulin proves effective stabilizing EVs, maintaining functionality after freezing −20 12 weeks. Freeze preserves 20 43% relative humidity. In contrast, mannitol exhibit aggregation reduce bio‐functionality. Additionally, leucine produces dry powder suitable inhalation, demonstrates efficient deposition using Cyclops inhaler. These findings suggest stabilizer eliminating need ultra‐low temperature improving practicality EV‐based inhalable therapies.

Language: Английский

Citations

0