Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus

Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(9), P. 101727 - 101727

Published: Aug. 2, 2023

In the past, curcumin was go-to medication for diabetes, but recent studies have shown that tetrahydrocurcumin is more effective. The problem it's not very soluble in water or bioavailable. So, our research aims to increase bioavailability and anti-diabetic efficacy of streptozotocin-induced diabetic rats by synthesizing tetrahydrocurcumin-loaded solid lipid nanoparticles. Box Behnken Design employed optimization nanoparticles (THC-SLNs). optimal formulation determined doing an ANOVA examine relationship between independent variables (drug-to-lipid ratio, surfactant concentration, co-surfactant concentration) dependent (particle size, percent entrapment efficiency, PDI). Particle PDI, efficiency all showed statistical significance based on F-values p-values. optimized batch prepared using a drug-to-lipid ratio (1:4.16), 1.21% concentration surfactant, 0.4775% (observed with particle size 147.1 nm, 83.58 ± 0.838 % 0.265 values were found close predicted ones. As THC peak vanishes from DSC thermogram improved formulation, this indicates drug has been transformed its crystalline form into amorphous state. TEM analysis demonstrated mono-dispersed particles average 145 nm which are closely related zetasizer's results. In-vitro release study burst followed sustained up 71.04% throughout 24 hrs. Increased adjusted THC-SLN vivo pharmacokinetics 9.47 folds higher AUC(0-t) compared plain THC-suspension. Additionally, pharmacodynamic experiments marked decrease blood glucose level 63.7% increased body weight 195.8 7.223 231.2 7.653 28th day better effect than suspension. Results stability revealed can be stored longer periods at room temperature. Tetrahydrocurcumin effectively administered SLN treatment diabetes.

Language: Английский

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Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2698 - 2698

Published: Sept. 9, 2023

This research presents a straightforward, effective, and eco-friendly method for the production of silver nanoparticles (AgNPs) copper oxide (CuONPs) using dried fruit Amomum subulatum as reducing, stabilizing, capping agent. The formation AgNPs CuONPs is supported by presence surface plasmon resonance band (SPR) at 440 nm 245 CuONPs. Additionally, identification specific biomolecules responsible synthesis was confirmed through FTIR spectra analysis. Transmission electron microscope (TEM) images demonstrated that had spherical shapes, with mean particle diameters 20.6 24.7 nm, respectively. X-ray diffraction selected area (SAED) analyses provided evidence crystalline nature synthesized elements observed energy-dispersive spectroscopy (EDS) Furthermore, antibacterial activity found to be superior against human pathogens such Escherichia coli, Staphylococcus aureus, Bacillus subtilis. cytotoxic biosynthesized (NPs) evaluated in vitro cervical cells (HeLa) breast (MCF-7). In MCF-7 cells, IC50 value estimated 39.79 µg/mL, while 83.89 µg/mL. HeLa 45.5 CuONPs, it 97.07 For first time, an from extract has been discussed along their comparative evaluation study. These results highlight promising applications effective agents microbial infections potential candidates cancer therapy.

Language: Английский

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Mitochondrial signaling pathways and their role in cancer drug resistance

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329

Published: Aug. 5, 2024

Language: Английский

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Cisplatin Resistance in Cancer Therapy: Causes and Overcoming Strategies

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(25)

Published: June 26, 2024

Abstract Dr. S. Shruthi, Prof. K. Bhasker Shenoy. Cisplatin (CDDP) is the first metal‐based drug and has been a popular in treatment of various types cancer for decades. Cancer cell death promoted by this platinum‐based generating DNA adducts activating apoptotic signaling pathways. The development resistance foremost clinical concern that compromises its efficacy. mechanism CDDP encompasses changes influx efflux, accumulation reduction, enhanced detoxification, repair which may affect therapeutic value. Researchers have paid significant attention to overcoming resistance, provides an opportunity enhance outcomes. Combinational therapy, use analogs, phytochemicals, nanoparticle‐mediated delivery, gene targeting regulation induced epigenetic are specific regimens overcome burden. In review, we summarize mechanisms involved strategies considered these hurdles concerning preclinical studies. This provide insights into further novel approaches uproot ascertain safer more effective therapy.

Language: Английский

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Transforming cancer treatment: The potential of nanonutraceuticals

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124919 - 124919

Published: Nov. 7, 2024

Language: Английский

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Unravelling the rheological and multifunctionality of Justicia adhatoda-impregnated carboxymethyl cellulose hydrogels for drug delivery systems

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141419 - 141419

Published: Feb. 1, 2025

Language: Английский

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Insights on the Role of Polyphenols in Combating Cancer Drug Resistance

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1709 - 1709

Published: June 14, 2023

Chemotherapy resistance is still a serious problem in the treatment of most cancers. Many cellular and molecular mechanisms contribute to both inherent acquired drug resistance. They include use unaffected growth-signaling pathways, changes tumor microenvironment, active transport medicines out cell. The antioxidant capacity polyphenols their potential inhibit activation procarcinogens, cancer cell proliferation, metastasis, angiogenesis, as well promote inhibition or downregulation efflux transporters, have been linked reduced risk epidemiological studies. Polyphenols also ability alter immunological responses inflammatory cascades, trigger apoptosis cells. discovery relationship between abnormal growth signaling metabolic dysfunction cells highlights importance further investigating effects dietary polyphenols, including boost efficacy chemotherapy avoid multidrug (MDR). Here, it summarized what known regarding effectiveness natural polyphenolic compounds counteracting that might develop drugs result variety different mechanisms.

Language: Английский

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Last Fifteen Years of Nanotechnology Application with Our Contribute

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 265 - 265

Published: Feb. 10, 2025

Currently, nanotechnology is the most promising science, engineering, and technology conducted at nanoscale (nm), which used in several sectors. Collectively, causing a new industrial revolution, nano-based products are becoming increasingly important for global market economy. The interest nanomaterials has been strongly augmented during last two decades, this fact can be easily evaluated by considering number of studies present literature. In November 2024, they accounted 764,279 experimental developed years 2009–2024. During such period, our group contributed to field applicative with review articles, we hope could have relevantly enhanced knowledge scientific community. publication, an exhaustive overview regarding main types nanomaterials, characterization techniques, their applications discussed. Particular attention paid employed enhancement bioavailability delivery bioactive molecules those ameliorating traditional food packaging. Then, briefly reviewed on development nanoparticles (NPs), dendrimers, micelles, liposomes biomedical collecting inherent details reader-friendly table. A brief excursus about reviews topic also provided, followed stinging question nanotoxicology. Indeed, although application translates into great improvement properties non-nanosized pristine materials, there may still not totally predictable risk humans, animals, environment associated extensive NPs. Nanotoxicology science rapid expansion, but sneaky risks yet fully disclosed. So, final part study discusses pending issue related possible toxic effects NPs impact customers’ acceptance scenario limited knowledge.

Language: Английский

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Nanotherapeutics in malaria

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 495 - 522

Published: Jan. 1, 2025

Language: Английский

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Nanotherapeutics in tuberculosis: Pulmonary and extrapulmonary applications

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 239 - 268

Published: Jan. 1, 2025

Language: Английский

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