Hemotoxic effects of polyethylene microplastics on mice DOI Creative Commons

Souzan Abdel‐Zaher,

Mahmoud S. Mohamed,

Alaa El‐Din H. Sayed

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: March 8, 2023

Micro- or nanoplastics, which are fragmented otherwise tiny plastic materials, have long been a source of environmental worry. Microplastics (MPs) well documented to alter the physiology and behavior marine invertebrates. The effects some these factors also seen in larger vertebrates, such as fish. More recently, mouse models used investigate potential impacts micro- nanoplastics on host cellular metabolic damages mammalian gut flora. impact erythrocytes, carry oxygen all cells, has not yet determined. Therefore, current study aims ascertain exposure various MP levels hematological alterations biochemical indicators liver kidney functions. In this study, C57BL/6 murine model was concentration-dependently exposed microplastics (6, 60, 600 μg/day) for 15 days, followed by days recovery. results demonstrated that μg/day MPs considerably impacted RBCs’ typical structure, resulting numerous aberrant shapes. Furthermore, concentration-dependent reductions markers were observed. Additional testing revealed renal functioning. Taken together, reveals severe blood parameters, erythrocyte deformation, consequently, anemic patterns blood.

Language: Английский

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events DOI
Raffaele Marfella, Francesco Prattichizzo, Celestino Sardu

et al.

New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 390(10), P. 900 - 910

Published: March 6, 2024

Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.

Language: Английский

Citations

395
The potential impacts of micro-and-nano plastics on various organ systems in humans DOI Creative Commons
Nurshad Ali,

Jenny Katsouli,

Emma L. Marczylo

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104901 - 104901

Published: Dec. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Language: Английский

Citations

134
Microplastics: Detection in human samples, cell line studies, and health impacts DOI Creative Commons
‪Damià Barceló, Yolanda Picó, Ahmed Alfarhan

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 101, P. 104204 - 104204

Published: June 28, 2023

Microplastics (MPs) are in all environmental compartments, including atmosphere, terrestrial, and aquatic environments as well marine organisms, foods, drinking water, indoor outdoor environments. MPs can enter the human body through food chain contaminated environment. Ingestion, inhalation, dermal contact routes of their entry into body. Recent studies reporting detection within have raised concern among scientific community knowledge about exposure is still very limited impact on health not well-understood yet. In this review article, we briefly cover reports evidencing MP body, e.g., stool, placenta, lungs, liver, sputum, breast milk, blood. A concise synopsis sample preparation analysis such matrices also provided. This article presents a summary effect cell lines health.

Language: Английский

Citations

116
Raman Microspectroscopy evidence of microplastics in human semen DOI Creative Commons
Luigi Montano, Elisabetta Giorgini, Valentina Notarstefano

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165922 - 165922

Published: July 31, 2023

The presence of microplastics (MPs) in human fluids and organs is a great concern, since, as highlighted by recent studies on animal models, they could cause alterations several physiological functions, including reproduction. In this study, semen samples collected from men living polluted area the Campania Region (Southern Italy), were analyzed to assess MPs. N. 16 pigmented microplastic fragments (ranging 2 6 μm size) with spheric or irregular shapes found six out ten samples. All detected MPs characterized terms morphology (size, colour, shape) chemical composition Raman Microspectroscopy. Chemical showed polypropylene (PP), polyethylene (PE), terephthalate (PET), polystyrene (PS), polyvinylchloride (PVC), polycarbonate (PC), polyoxymethylene (POM) acrylic, suggesting ingestion and/or inhalation route exposure environmental work, we propose for first time mechanism which pass into most likely through epididymis seminal vesicles, are susceptible inflammation.

Language: Английский

Citations

105
A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health DOI Creative Commons
Yudong Feng,

Chen Tu,

Ruijie Li

et al.

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

Citations

81
MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue DOI Creative Commons
Sara Massardo, Daniela Verzola, Stefano Alberti

et al.

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108444 - 108444

Published: Jan. 19, 2024

There is a growing concern within the medical community about potential burden of microplastics on human organs and tissues. In this study, we investigated by microRaman spectroscopy presence in kidneys urine. Moreover, an open-access software was developed validated for project, which enabled comparison between spectra self-created spectral database, thus enhancing ability to characterize polymers pigments biological matrices. Healthy portions ten obtained from nephrectomies, as well urine samples healthy donors were analyzed: 26 particles both kidney identified, with sizes ranging 3 13 μm 1 29 kidneys. The most frequently determined are polyethylene polystyrene, while common hematite Cu-phthalocyanine. This preclinical study proves renal tissues confirms their urine, providing first evidence deposition humans.

Language: Английский

Citations

64
Microplastics and additives in patients with preterm birth: The first evidence of their presence in both human amniotic fluid and placenta DOI Creative Commons
Jan Halfar, Kristína Čabanová, Karel Vávra

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 343, P. 140301 - 140301

Published: Sept. 26, 2023

Considering the well documented, almost ubiquitous nature of microplastics in different environments, exposure pregnant women to may pose risks unborn children. The study focused on investigating presence amniotic fluid and placenta, brings first evidence simultaneous additives both human placentas. In total, 20 samples placenta from 10 patients were analyzed for plastic by Fourier transform infrared spectroscopy - attenuated total reflectance (FTIR-ATR) after alkaline digestion with KOH. 9 out patients, or found fluid, both. Specifically, 44 particles polymer identified all samples. Chlorinated Polyethylene (CPE) Calcium zinc PVC Stabilizer particle sizes between 50 μm prevailed. Although involved this study, who provided samples, experienced physiological, singleton pregnancies complicated preterm prelabour rupture membranes (PPROM), it is too early draw any conclusions more research needed.

Language: Английский

Citations

51
Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks DOI
Penghui Li,

Jingfu Liu

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Language: Английский

Citations

42
Microplastics exposure: implications for human fertility, pregnancy and child health DOI Creative Commons

Rewa E. Zurub,

Yusmaris Cariaco, Michael G. Wade

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, the extent of exposure potential toxic effects these contaminants on numerous human organ systems clear. Microplastics (MPs), tiny plastic particles, appear to have many same biological as their precursors compounded effect accumulation different organs. Recently, microplastic was observed placenta, raising important questions related health pregnancies offspring. These concerns particularly heightened considering developmental origins disease (DOHaD) framework, which postulates that utero can programme lifelong The current review examines state knowledge this topic highlights avenues future investigation.

Language: Английский

Citations

38
Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dysfunction via the NF-κB/NLRP3/IL-1β/MCLK pathway DOI
Guodong Zeng,

Jingyi Li,

Yuanli Wang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123473 - 123473

Published: Jan. 30, 2024

Language: Английский

Citations

23