Current Clinical Landscape and Global Potential of Bacteriophage Therapy

Viruses, Journal Year: 2023, Volume and Issue: 15(4), P. 1020 - 1020

Published: April 21, 2023

In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known their potential clinical utility in lysing bacteria almost a century. Social pressures concomitant introduction antibiotics mid-1900s hindered widespread adoption these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as promising strategy combatting resistance. A unique mechanism action cost-effective production promotes phages ideal solution addressing antibiotic-resistant bacterial infections, particularly lower- middle-income countries. As number phage-related research labs worldwide continues grow, it will be increasingly important encourage expansion well-developed trials, standardization storage cocktails, advancement international collaboration. this review, we discuss history, benefits, limitations bacteriophage its current role setting resistance with specific focus on active trials case reports administration.

Language: Английский

---

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(5), P. 262 - 275

Published: Dec. 11, 2023

Language: Английский

---

Antimicrobial Drug Resistance in Poultry Production: Current Status and Innovative Strategies for Bacterial Control

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 953 - 953

Published: April 6, 2023

The world population’s significant increase has promoted a higher consumption of poultry products, which must meet the specified demand while maintaining their quality and safety. It is well known that conventional antimicrobials (antibiotics) have been used in livestock production, including poultry, as preventive measure against or for treatment infectious bacterial diseases. Unfortunately, use misuse these compounds led to development dissemination antimicrobial drug resistance, currently serious public health concern. Multidrug-resistant bacteria are on rise, being responsible infections humans animals; hence, goal this review discuss consequences resistance focusing current status agroeconomic sector. Novel control strategies under investigation application industry also described. These innovative approaches include peptides, bacteriophages, probiotics nanoparticles. Challenges related methods discussed.

Language: Английский

---

Antimicrobial Peptides as an Alternative for the Eradication of Bacterial Biofilms of Multi-Drug Resistant Bacteria

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 642 - 642

Published: March 15, 2022

Bacterial resistance is an emergency public health problem worldwide, compounded by the ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World Health Organization has published a list priority that should be studied and, turn, encouraged development new drugs. Herein, we explain importance studying molecules such as antimicrobial peptides (AMPs) with potential against multi-drug resistant (MDR) and extensively drug-resistant (XDR) focus on inhibition biofilm formation. This review describes main causes formation, well AMP applications these bacteria. Our results suggest biomacromolecules discovered this group dangerous highly infectious Alternative AMPs could contribute eradicating proliferation MDR/XDR bacteria; challenging undertaking promising prospects.

Language: Английский

---

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: June 29, 2023

The human–bacterial association is long-known and well-established in terms of both augmentations human health attenuation. However, the growing incidents nosocomial infections caused by ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus Klebsiella pneumoniae Acinetobacter baumannii Pseudomonas aeruginosa Enterobacter sp.) call for a much deeper understanding these organisms. Adopting holistic approach that includes science infection recent advancements preventing treating imperative designing novel intervention strategies against pathogens. In this regard, review captures ingenious commissioned master players, which are teamed up defenses team, equally, if not more, versatile potent through an analogy. We have taken basketball match as our analogy, dividing bacterial species into two teams playing with ball health. Through we make concept infectious biology more accessible.

Language: Английский

---

Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance

Annual Review of Virology, Journal Year: 2023, Volume and Issue: 10(1), P. 503 - 524

Published: June 2, 2023

The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy antibiotics urge consideration alternative antimicrobial strategies. Phage therapy is a classic approach where bacteriophages (bacteria-specific viruses) are used against infections, with many recent successes personalized medicine treatment intractable infections. However, perpetual challenge for developing generalized phage expectation that viruses will exert selection target bacteria to deploy defenses virus attack, causing evolution during patient treatment. Here we review two main complementary strategies mitigating therapy: minimizing ability populations evolve driving (steering) phage-resistant toward clinically favorable outcomes. We discuss future research directions might further address phage-resistance problem, foster widespread development deployment therapeutic outsmart evolved clinical settings.

Language: Английский

---

Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(6), P. 1054 - 1070.e9

Published: May 18, 2023

Language: Английский

---

Methicillin Resistant Staphylococcus aureus: Molecular Mechanisms Underlying Drug Resistance Development and Novel Strategies to Combat

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 7641 - 7662

Published: Dec. 1, 2023

Antimicrobial resistance (AMR) represents a major threat to global health. Infection caused by Methicillin-resistant Staphylococcus aureus (MRSA) is one of the well-recognized public health problem globally. In some regions, as many 90% S. infections are reported be MRSA, which cannot treated with standard antibiotics. WHO reports indicated that MRSA circulating in every province worldwide, significantly increasing risk death 64% compared drug-sensitive forms infection attributed its antibiotic resistance. The emergence and spread antibiotic-resistant strains have contributed increased prevalence both healthcare community settings. methicillin due expression penicillin-binding protein 2a (PBP2a), renders it impervious action β-lactam antibiotics including methicillin. other through production beta-lactamases. Although treatment options for limited, there promising alternatives combat infections. Innovative therapeutic strategies wide range activity modes yet explored. review highlights challenges posed elucidates mechanisms underlying development, explores mitigation strategies. Furthermore, focuses on alternative therapies such bacteriophages, immunotherapy, nanobiotics, antimicrobial peptides, emphasizing their synergistic effects efficacy against MRSA. By examining these approaches, this provides insights into potential tackling combatting escalating AMR. Ultimately, multifaceted approach encompassing conventional novel interventions imperative mitigate impact ensure sustainable future healthcare.

Language: Английский

---

Bacteriophage–Host Interactions and the Therapeutic Potential of Bacteriophages

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 478 - 478

Published: March 20, 2024

Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide solution treatment bacterial infections given their specificity. Enzymes such as endolysins, exolysins, endopeptidases, endosialidases, and depolymerases produced by phages interact surfaces, cell wall components, exopolysaccharides, even destroy biofilms. Enzymatic cleavage host envelope components exposes specific receptors required for phage adhesion. Gram-positive bacteria are susceptible infiltration through peptidoglycan, teichoic acid (WTA), lipoteichoic acids (LTAs), flagella. In Gram-negative bacteria, lipopolysaccharides (LPSs), pili, capsules serve targets. Defense mechanisms used differ include physical barriers (e.g., capsules) or endogenous clustered regularly interspaced palindromic repeat (CRISPR)-associated protein (Cas) systems. Phage proteins stimulate immune responses against pathogens improve antibiotic susceptibility. This review discusses attachment cells, penetration use in infections, limitations therapy. The therapeutic potential phage-derived impact that genomically engineered have summarized.

Language: Английский

---

Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 26, 2024

Inflammatory periodontal diseases associated with the accumulation of dental biofilm, such as gingivitis and periodontitis, are very common pose clinical problems for clinicians patients. Gingivitis is a mild form gum disease when treated quickly properly completely reversible. Periodontitis an advanced irreversible periodontium periods exacerbations, progressions remission. chronic inflammatory condition that damages tissues supporting tooth in its socket, i.e., gums, ligaments, root cementum bone. Periodontal inflammation most commonly triggered by bacteria present excessive accumulations plaque (biofilm) on surfaces. This driven disproportionate host immune responses induced imbalance composition oral changes their metabolic activities. microbial dysbiosis favors establishment conditions ultimately results destruction tooth-supporting tissues. Apart shift response, environmental factors genetics also important etiology In addition to destruction, can result significant systemic complications. Conventional methods treatment (improving hygiene, biofilm control, mechanical removal, using local or antimicrobial agents) not fully effective. All this prompts search new therapy. Advanced periodontitis multiple abscesses often antibiotics, amoxicillin, tetracycline, doxycycline, minocycline, clindamycin, combined therapy amoxicillin metronidazole. However, due growing problem antibiotic resistance, does always achieve desired therapeutic effect. review summarizes pathogenesis, current approaches treatment, limitations state research possibility application bacteriophages predatory combat responsible periodontitis. We landscape potential applications alternative therapies based phages bacteria, highlight gaps existing knowledge need be addressed before trials utilizing these strategies seriously considered.

Language: Английский

---