Assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms DOI Creative Commons
Lavandan Jegatheeswaran, Shyam Gokani, Louis Luke

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 4, 2023

Purpose of review To provide a detailed overview the assessment COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, cognitive symptoms. Recent findings can have detrimental impact to quality life patients. Prior COVID-19 pandemic, taste disorders were common but under-rated, under-researched under-treated sensory loss. The pandemic has exacerbated current unmet need for accessing good healthcare patients living other symptoms secondary COVID-19. This thus explores associations that symptoms, framework rationale presenting dysfunction. Summary Acute infection long COVID is not solely disease respiratory vascular systems. These two conditions strong A systematic approach history taking examination particularly nasal endoscopy determine this on patient. Specific disorder questionnaires demonstrate life, while psychophysical testing objectively assess monitor olfaction over time. role cross-sectional imaging yet described Management options are limited conservative adjunctive measures, some medical therapies described.

Language: Английский

Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves DOI Creative Commons
Benjamin Kye Jyn Tan, Ruobing Han, Joseph J. Zhao

et al.

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e069503 - e069503

Published: July 27, 2022

To clarify in patients with covid-19 the recovery rate of smell and taste, proportion persistent dysfunction prognostic factors associated taste.

Language: Английский

Citations

182
Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms DOI Creative Commons
Rafał Butowt, Katarzyna Bilińska, Christopher S. von Bartheld

et al.

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 46(1), P. 75 - 90

Published: Nov. 16, 2022

Language: Английский

Citations

91
The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients DOI Creative Commons
Luigi Angelo Vaira, C. Gessa, Giovanna Deiana

et al.

Life, Journal Year: 2022, Volume and Issue: 12(2), P. 141 - 141

Published: Jan. 19, 2022

(1) Background: Persistent olfactory (POD) and gustatory (PGD) dysfunctions are one of the most frequent symptoms long-Coronavirus Disease 2019 but their effect on quality life (QoL) patients is still largely unexplored. (2) Methods: An online survey was administered to individuals who reported have had SARS-CoV-2 infection at least 6 months prior with persisting COVID-19 (using COVID symptom index), including ratings POD PGD, physical (PCS) mental (MCS) components were assessed using standardized short form 12 questionnaire (SF-12). (3) Results: Responses from 431 unique included in analyses. The persistent were: fatigue (185 cases, 42.9%), dysfunction (127 29.5%), (96 22.3%) muscle pain (83 19.3%). Respondents pain, joint fatigue, headache, gastrointestinal disturbances, dyspnea significantly worse PCS. Those experiencing also showed lower MCS. reporting or PGD QoL, only pertaining Multiple regressions predicted MCS based marginally ratings, not Age affected prediction PCS MCS, gender temporal distance diagnosis no effect. (4) Conclusions: long-COVID-19 syndrome reduce specifically health component. This evidence should stimulate establishment appropriate infrastructure support CD, while research effective therapies scales up.

Language: Английский

Citations

55
Sociodemographic Characteristics and Comorbidities of Patients With Long COVID and Persistent Olfactory Dysfunction DOI Creative Commons
Alna Carolina Mendes Paranhos, Ápio Ricardo Nazareth Dias, Livia Caroline Machado da Silva

et al.

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(9), P. e2230637 - e2230637

Published: Sept. 8, 2022

Determining the characteristics, type, and severity of olfactory dysfunction in patients with long COVID is important for prognosis potential treatment affected population.To describe sociodemographic clinical features who develop persistent dysfunction.This cross-sectional study, conducted at a rehabilitation center public university Amazon region Brazil between September 9, 2020, October 20, 2021, comprised 219 self-reported neurologic symptoms. Of these patients, 139 received diagnosis chronic dysfunction, as confirmed by Connecticut Chemosensory Clinical Research Center (CCCRC) test.Clinical COVID.Electronic case report forms were prepared collection data. Patients' sense smell was evaluated via CCCRC test, association aspects daily life recorded using questionnaire.Of included 164 (74.9%) women, 194 (88.6%) 18 59 years age (mean [SD] age, 43.2 [12.9] years), 206 (94.1%) had more than 9 education, 115 (52.5%) monthly income up to US $192.00. In study group, (63.5%) some degree whereas 80 (36.5%) normosmia. Patients significantly longer duration symptoms those normosmia group [SD], 242.7 [101.9] vs 221.0 [97.5] days; P = .01). Among anosmia, there significant activities, especially terms impairment hazard detection (21 31 [67.7%]), personal hygiene food intake [67.7%]). Univariable logistic regression analyses found that ageusia associated occurrence (odds ratio [OR], 11.14 [95% CI, 4.76-26.07]; < .001), headache (OR, 0.41 0.22-0.76]; .001) sleep disorders 0.48 0.26-0.92]; .02) showed an inverse dysfunction.Olfactory one most long-term COVID-19, highest prevalence seen among adults, outpatients. may experience severe hyposmia or anosmia 1 year from onset symptoms, suggesting possibility condition becoming permanent sequela.

Language: Английский

Citations

33
Neuroradiological Basis of COVID‐19 Olfactory Dysfunction: A Systematic Review and Meta‐Analysis DOI
Claire Jing‐Wen Tan, Benjamin Kye Jyn Tan,

Xin Yan Tan

et al.

The Laryngoscope, Journal Year: 2022, Volume and Issue: 132(6), P. 1260 - 1274

Published: March 22, 2022

Objective Olfactory dysfunction (OD) is a common presenting symptom of COVID‐19 infection. Radiological imaging the olfactory structures in patients with and OD can potentially shed light on its pathogenesis, guide clinicians prognostication intervention. Methods PubMed, Embase, Cochrane, SCOPUS were searched from inception to August 1, 2021. Three reviewers selected observational studies, case series, reports reporting radiological changes structures, detected magnetic resonance imaging, computed tomography, or other modalities, aged ≥18 years infection OD, following preferred items for systematic reviews meta‐analyses guidelines PROSPERO‐registered protocol (CRD42021275211). We described proportion outcomes, used random‐effects pool prevalence cleft opacification, bulb signal abnormalities, mucosa abnormalities without COVID‐19‐associated OD. Results included 7 case–control studies ( N = 353), 11 series 154), 12 12). The pooled opacification (63%, 95% CI 0.38–0.82) was significantly higher than that controls (4%, 0.01–0.13). Conversely, similar proportions cases demonstrated (88% 94%) (2% 0%). Descriptive analysis found 55.6% 43.5% had morphological nerve, respectively, while 60.0% abnormal volumes. Conclusion Our findings implicate conductive mechanism localized cleft, approximately half affected patients. Laryngoscope , 132:1260–1274, 2022

Language: Английский

Citations

26
A Comprehensive Review of COVID-19-Related Olfactory Deficiency: Unraveling Associations with Neurocognitive Disorders and Magnetic Resonance Imaging Findings DOI Creative Commons
Ludovica Simonini, Francesca Frijia, Lamia Ait‐Ali

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(4), P. 359 - 359

Published: Feb. 7, 2024

Olfactory dysfunction (OD) is one of the most common symptoms in COVID-19 patients and can impact patients’ lives significantly. The aim this review was to investigate multifaceted on olfactory system provide an overview magnetic resonance (MRI) findings neurocognitive disorders with COVID-19-related OD. Extensive searches were conducted across PubMed, Scopus, Google Scholar until 5 December 2023. included articles 12 observational studies 1 case report that assess structural changes structures, highlighted through MRI, 10 correlating loss smell or mood patients. MRI consistently indicate volumetric abnormalities, altered signal intensity bulbs (OBs), anomalies cortex among persistent correlation between OD deficits reveals associations cognitive impairment, memory deficits, depressive symptoms. Treatment approaches, including training pharmacological interventions, are discussed, emphasizing need for sustained therapeutic interventions. This points out several limitations current literature while exploring intricate effects its connection disorders. lack objective measurements some potential validity issues self-reports emphasize cautious interpretation. Our research highlights critical extensive larger samples, proper controls, deepen our understanding COVID-19’s long-term neurological dysfunctions.

Language: Английский

Citations

5
Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service DOI Creative Commons
Alessandro Gambella, Antonella Barreca, Luigi Biancone

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(2), P. 298 - 298

Published: Feb. 12, 2022

The onset of coronavirus disease (COVID-19) as a pandemic infection, has led to increasing insights on its pathophysiology and clinical features being revealed, such noticeable kidney involvement. In this study, we describe the histopathological, immunofluorescence, ultrastructural biopsy-proven injury observed in series SARS-CoV-2 positive cases our institution from April 2020 November 2021. We retrieved retrospectively reviewed nine (two pediatric seven adults) that experienced nephrotic syndrome (six cases), acute clinically silent microhematuria leukocyturia. Kidney biopsies were investigated by means light microscopy, direct electron microscopy. primary diagnoses minimal change (four tubular necrosis collapsing glomerulopathy C3 (one case). None showed viral or viral-like particles analysis. Novel specific histologic biopsy related infection have been gradually disclosed reported, harboring relevant therapeutic implications. Recognizing properly diagnosing renal involvement patients experiencing COVID-19 could be challenging (due lack proof e.g., particles) requires proper integration pathological data.

Language: Английский

Citations

22
The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction DOI Creative Commons
Shunmei Chen,

Shufen Wang

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 17, 2023

During the first waves of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, olfactory dysfunction (OD) was reported as a frequent clinical sign. The nasal epithelium is one front-line protections against viral infections, and immune responses mucosa may be associated with OD. Two mechanisms underlying OD occurrence in COVID-19 have been proposed: infection sustentacular cells inflammatory reaction epithelium. former triggers latter likely prolongs These two alternative act parallel; more important for because are to entry point SARS-CoV-2 than neurons susceptible early injury. Furthermore, abundantly express transmembrane protease, serine (TMPRSS2) play major role has revealed crucial roles cells. This review aims elucidate how contribute COVID-19–related Understanding aid development improved medical treatments

Language: Английский

Citations

11
Risk of MS relapse and deterioration after COVID-19: A systematic review and meta-analysis DOI
Homa Seyedmirzaei, Dorsa Salabat,

Sara KamaliZonouzi

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105472 - 105472

Published: Jan. 25, 2024

Language: Английский

Citations

4
Long COVID-19–related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs DOI Creative Commons
Yifan Li,

Mengfan Liu,

Ruoqi Zhang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

To compare the magnetic resonance imaging (MRI) features of olfactory cleft (OC) and bulbs (OBs) in patients with long COVID-19-related (LCOD) non-COVID-19 postviral dysfunction (NCPVOD) to explore mechanisms underlying persistent dysfunction. This retrospective analysis included diagnosed LCOD or NCPVOD at China-Japan Friendship Hospital between February 2023 July 2024. All underwent psychophysical testing (Sniffin' Sticks), a visual analogue scale (VAS) for function, high-resolution MRI scans pathway. features, including OC opacity, OB morphology, volume, sulcus depth, were compared groups. Correlations findings test scores assessed. Seventy (35 LCOD, 35 NCPVOD). had significantly higher opacity than (p < 0.001). No significant differences found abnormal signals, volume reduction, distances OBs surrounding structures > 0.05). greater right depth = 0.026), negative correlation age (r -0.25, p 0.04). volumes positively correlated TDI VAS scores. exhibited patients, suggesting inflammation may contribute Treating could improve long-term outcomes. reduction was common both

Language: Английский

Citations

0