Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

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Approach to the diagnosis and management of dysbiosis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 19, 2024

All microorganisms like bacteria, viruses and fungi that reside within a host environment are considered microbiome. The number of bacteria almost equal human cells, however, the genome these may be 100 times larger than genome. Every aspect physiology health can influenced by microbiome living in various parts our body. Any imbalance composition or function is seen as dysbiosis. Different types dysbiosis corresponding symptoms depend on site microbial imbalance. contribution intestinal extra-intestinal microbiota to influence systemic activities through interplay between different axes. Whole body complex process involving gut non-gut related It still at stage infancy has not yet been fully understood. Dysbiosis genetic factors, lifestyle habits, diet including ultra-processed foods food additives, well medications. associated with many diseases cannot diagnosed standard blood tests investigations. Microbiota derived metabolites analyzed useful management addressed altering proper modulation. effect interventions humans depends beneficial alteration mostly based animal studies evolving evidence from studies. There tremendous potential for diagnosis, treatment, prognosis diseases, as, monitoring disease humans. system-based approach diagnosis better pure taxonomic approach. could new therapeutic target conditions.

Language: Английский

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Butyrate as a potential therapeutic agent for neurodegenerative disorders

Neurochemistry International, Journal Year: 2024, Volume and Issue: 176, P. 105745 - 105745

Published: April 18, 2024

Language: Английский

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Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review)

Oncology Letters, Journal Year: 2024, Volume and Issue: 27(2)

Published: Jan. 5, 2024

Immune checkpoint inhibitors (ICIs) are commonly utilized in tumor treatment. However, they still have limitations, including insufficient effectiveness and unavoidable adverse events. It has been demonstrated that gut microbiota can influence the of ICIs, although precise mechanism remains unclear. Gut plays a crucial role formation development immune system. their associated metabolites play regulatory balance. Tumor occurrence linked to ability evade recognition destruction by The purpose ICIs treatment is reinitiate system's elimination cells. Thus, system acts as communication bridge between ICIs. Varied composition characteristics result diverse outcomes Certain microbiota‑related also therapeutic efficacy some extent. administration antibiotics before or during diminish effectiveness. utilization probiotics fecal transplantation partially alter outcome present review synthesized previous studies examine association elucidated its factors treatment, offered direction for future research.

Language: Английский

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Intestinal Dysbiosis: Microbial Imbalance Impacts on Colorectal Cancer Initiation, Progression and Disease Mitigation

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 740 - 740

Published: March 26, 2024

The human gastrointestinal tract houses a diverse range of microbial species that play an integral part in many biological functions. Several preclinical studies using germ-free mice models have demonstrated the gut microbiome profoundly influences carcinogenesis and progression. Colorectal cancer appears to be associated with dysbiosis involving certain bacterial species, including F. nucleatum, pks+ E. coli, B. fragilis, virome commensals also disrupted patients. A toward these pro-carcinogenic increases significantly CRC patients, reduced numbers preventative Clostridium butyicum, Roseburia, Bifidobacterium evident. There is correlation between infection CRC. particular, strongly where it therapeutic resistance poor outcomes carcinogenic mode action pathogenic bacteria result genotoxicity, epigenetic alterations, ROS generation, pro-inflammatory activity. aim this review discuss their impact on colorectal terms disease initiation, progression, metastasis. potential anticancer peptides as agents or adjuvants discussed, novel treatment options are required combat high levels current pharmaceutical options.

Language: Английский

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Cancer, deuterium, and gut microbes: A novel perspective

Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: unknown, P. 100215 - 100215

Published: Jan. 1, 2025

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Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940

Published: March 10, 2025

Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.

Language: Английский

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The role of short-chain fatty acids in cancer prevention and cancer treatment

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110172 - 110172

Published: Oct. 4, 2024

Language: Английский

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Role of Gut Microbial Metabolites in the Pathogenesis of Primary Liver Cancers

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2372 - 2372

Published: July 22, 2024

Hepatobiliary malignancies, which include hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are the sixth most common cancers third leading cause of cancer-related death worldwide. Hepatic carcinogenesis is highly stimulated by chronic inflammation, defined as fibrosis deposition, an aberrant imbalance between liver necrosis nodular regeneration. In this context, gut-liver axis gut microbiota have demonstrated a critical role in pathogenesis HCC, dysbiosis altered intestinal permeability promote bacterial translocation, to inflammation tumorigenesis through several pathways. A few data exist on or bacteria resident biliary tract CCA, some microbial metabolites, such choline bile acids, seem show association. review, we analyze impact its metabolites HCC CCA development biomarker hepatobiliary cancer risk response during anti-tumor therapy. We also discuss future application management.

Language: Английский

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Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 396 - 396

Published: Jan. 30, 2024

Cancer etiology involves complex interactions between genetic and non-genetic factors, with epigenetic mechanisms serving as key regulators at multiple stages of pathogenesis. Poor dietary habits contribute to cancer predisposition by impacting DNA methylation patterns, non-coding RNA expression, histone landscapes. Histone post-translational modifications (PTMs), including acyl marks, act a molecular code play crucial role in translating changes cellular metabolism into enduring patterns gene expression. As cells undergo metabolic reprogramming support rapid growth proliferation, nuanced roles have emerged for dietary- metabolism-derived acylation progression. Specific types acylation, beyond the standard acetylation shed light on how metabolites reshape gut microbiome, influencing dynamics repertoires. Given reversible nature PTMs, corresponding readers, writers, erasers are discussed this review context prevention treatment. The evolving ‘acyl code’ provides improved biomarker assessment clinical validation diagnosis prognosis.

Language: Английский

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