Pregestational Prediabetes Induces Maternal Hypothalamic–Pituitary–Adrenal (HPA) Axis Dysregulation and Results in Adverse Foetal Outcomes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5431 - 5431

Published: May 16, 2024

Maternal type 2 diabetes mellitus (T2DM) has been shown to result in foetal programming of the hypothalamic-pituitary-adrenal (HPA) axis, leading adverse outcomes. T2DM is preceded by prediabetes and shares similar pathophysiological complications. However, no studies have investigated effects maternal on HPA axis function postnatal offspring development. Hence, this study pregestational Pre-diabetic (PD) non-pre-diabetic (NPD) female Sprague Dawley rats were mated with non-prediabetic males. After gestation, male pups born from PD NPD groups collected. Markers function, adrenocorticotropin hormone (ACTH) corticosterone, measured all dams pups. Glucose tolerance, insulin gene expressions mineralocorticoid (MR) glucocorticoid (GR) receptors further at birth their developmental milestones. The results demonstrated increased basal concentrations ACTH corticosterone group comparison NPD. Furthermore, show an increase concentrations, disturbed MR GR expression, glucose intolerance resistance assessed via Homeostasis Model Assessment (HOMA) indices compared These observations reveal that associated dysregulation impacting development along impaired handling.

Language: Английский

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Increased risk of congenital malformations in offspring born to women with systemic lupus erythematosus in South Korea: a nationwide population-based study

RMD Open, Journal Year: 2023, Volume and Issue: 9(2), P. e002916 - e002916

Published: June 1, 2023

Objectives The aim of this study was to determine the risk congenital malformations in offspring born women with systemic lupus erythematosus (SLE). Methods This nationwide population-based included Korean who had a singleton pregnancy. SLE compared those without SLE. Multivariable analyses were performed estimate OR malformations. In sensitivity analysis, malformation between and propensity-matched Results Of total 3 279 204 pregnant women, 0.1% their higher frequency (17.13% vs 11.99%, p<0.0001). After adjustment for age, parity, hypertension, diabetes, fetal sex, group found be associated an increased nervous system (adjusted (aOR, 1.90; 95% CI, 1.20 3.03), eye, ear, face, neck 1.37; 1.09 1.71), circulatory 1.91; 1.67 2.20), musculoskeletal 1.26; 1.05 1.52). Even after propensity matching, some tendencies maintained. Conclusions South Korea indicates that general population, neonates mothers have slightly affecting system, head neck, cardiovascular system. When woman becomes pregnant, careful ultrasound newborn screening can helpful identifying potential

Language: Английский

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Transgenerational and intergenerational effects of early childhood famine exposure in the cohort of offspring of Leningrad Siege survivors

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 11, 2023

Famine exposure during early life development can affect disease risk in late-life period, yet, transmission of phenotypic features from famine-exposed individuals to the next generations has not been well characterized. The purpose our case-control study was investigate association parental starvation perinatal period and childhood with observed two descendants Leningrad siege survivors. We examined 54 children 30 grandchildren 58 besieged residents who suffered prenatal age Second World War. Controls population-based national epidemiological ESSE-RF (n = 175) were matched on sex, body mass index (BMI). Phenotypes controls (both generations, separately) compared, taking into account multiple testing. Comparison corresponding control groups revealed significantly higher creatinine lower glomerular filtration rate (GFR), both meta-analysis independent analyses. mean values GFR for all within normal range (GFR less than 60 mL/min/1.73 m2 recorded 2 no one DLSS). Additionally, level, differences eating pattern detected: insufficient fish excessive red meat consumption more frequent survivors compared controls. Blood pressure, blood lipids glucose did differ between groups. Parental famine may contribute a decrease kidney capacity altered offspring individuals.

Language: Английский

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Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1916 - 1916

Published: Oct. 26, 2023

Particulate matter 2.5 (PM

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Prenatal maternal alcohol exposure: diagnosis and prevention of fetal alcohol syndrome

Obstetrics & Gynecology Science, Journal Year: 2022, Volume and Issue: 65(5), P. 385 - 394

Published: July 31, 2022

Fetal alcohol syndrome (FAS) is a developmental and congenital disorder characterized by neurocognitive impairment, structural defects, growth restriction due to prenatal exposure. The estimated global prevalence of use during pregnancy 9.8%, the FAS in general population 14.6 per 10,000 people. In Korea, 16%, 18-51 women, which higher than prevalence. Women’s consumption rates have increased, especially women childbearing age. This could increase incidence FAS, leading medical expenses burden on society. Alcohol single most important teratogen that causes there no safe trimester drink known amount pregnancy. Thus, physicians should assess women’s drinking patterns detail provide education understanding its pathophysiology. Moreover, prevention requires long-term care with multidisciplinary approach.

Language: Английский

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Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 24, 2022

The predominance of vaginal Lactobacillus species, specifically L. crispatus, is important for pregnancy maintenance, but varies by race. composition the microbiome can affect susceptibility to adverse outcomes. We performed 16S rRNA gene amplicon sequencing on swabs taken from Korean pregnant women. Here, we report transition spp. in samples full-term birth (FTB) collected longitudinally second and third trimesters a cohort study (n = 23) their association with abundance preterm (PTB) case-control 200). which was dominant FTB including those that received interventions trimester, did not change until 37 weeks gestation. However, crispatus replaced other species after weeks. PTB risk showed closer than community state type determined species. associated less 90% an increase Ureplasma parvum trimester. Thus, may preparation childbirth response multiple intrinsic factors Monitoring help improve reliability microbial biomarkers.

Language: Английский

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The Risk of Hypertension and Diabetes Mellitus According to Offspring’s Birthweight in Women With Normal Body Mass Index: A Nationwide Population-Based Study

Journal of Korean Medical Science, Journal Year: 2024, Volume and Issue: 39(5)

Published: Jan. 1, 2024

Maladaptation to vascular, metabolic, and physiological changes during pregnancy can lead fetal growth disorders. Moreover, adverse outcomes further increase the risk of cardiovascular metabolic diseases in mothers. Delivering a large-for-gestational-age (LGA) baby may indicate pre-existing dysfunction, whereas delivering small-for-gestational-age (SGA) vascular dysfunction. This study aims assess hypertension (HTN) diabetes mellitus (DM) women with normal body mass index (BMI) scores who did not experience gestational DM or hypertensive disorders based on offspring's birthweight. retrospective nationwide included BMI delivered singleton after 37 weeks. Women history HTN before those disorders, were excluded from study. We compared future maternal (HTN DM) according Multivariate analyses performed estimate hazard ratio (HR) for DM. A total 64,037 analysis. Of these, very LGA babies (birthweight > 97th percentile) at higher developing than appropriate-for-gestational-age (AGA) (adjusted HR = 1.358 [1.068-1.727]), SGA < 3rd AGA 1.431 [1.181-1.734]), even adjusting age, parity, age delivery, sex, score, smoking. These findings provide novel support use birthweight as predictor such

Language: Английский

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Pregestational Prediabetes Induces Maternal Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation and Results in Adverse Fetal Outcomes: Influences on HPA Axis and Development

Published: March 29, 2024

Maternal type 2 diabetes mellitus (T2DM) has been shown to result in fetal programming of the hypothalamus-pituitary-adrenal (HPA) axis, leading adverse outcomes. T2DM is preceded by prediabetes and shares similar pathophysiological complications. However, no studies have investigated effects maternal on HPA axis function postnatal offspring development, hence this study. Pre-diabetic (PD) non-pre-diabetic (NPD) female Sprague Dawley rats were mated with non-prediabetic males. After gestation, male pups born from PD NPD groups collected. Markers function, adrenocorticotropin hormone (ACTH) corticosterone measured all dams pups. Glucose tolerance expression mineralocorticoid (MR) glucocorticoid (GR) receptors further at birth their developmental milestones. The results demonstrated increased basal concentrations ACTH group comparison NPD. Furthermore, show an increase concentrations, impaired glucose dysregulated MR GR These observations reveal that pregestational associated dysregulation impacting development along handling.

Language: Английский

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A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)‐ Associated Hypothalamic‐Pituitary‐Adrenal (HPA) Axis Dysregulation: Exploring Links to Pregestational Prediabetes

Published: April 16, 2024

A growing body of research has identified fetal risk factors associated with adult diseases that form the basis for Developmental Origins Health and Disease (DOHaD) hypothesis. This theory proposes a critical developmental period during which fetus is highly susceptible to specific environmental influences significantly impact health from short long term. Maternal stress T2DM pregnancy are among these influences, likely leading overexposure glucocorticoids suggesting shared pathway between maternal dysregulated HPA axis insults. Studies demonstrate prenatal glucocorticoid exposure alters function, affecting brain tissue availability, growth in utero. These programmed changes, such as altered function reduced growth, contribute metabolic disorders persisting into adulthood. preceded by prediabetic state, often asymptomatic, shares similar pathophysiological complications T2DM, including dysregulation observed animals. Therefore, investigating prediabetes alongside its effects on outcomes crucial, areas remain understudied. review aims synthesize existing literature pre-existing pregnancy, links programming via possible pregestational prediabetes.

Language: Английский

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The role of the family environment and parental nutritional knowledge in the prevention of behavioral feeding disorders in toddlers and preschool children – a narrative review

Journal of Health Inequalities, Journal Year: 2024, Volume and Issue: 10(1), P. 56 - 63

Published: Jan. 1, 2024

AMA Kawecka P, Kostecka M. The role of the family environment and parental nutritional knowledge in prevention behavioral feeding disorders toddlers preschool children – a narrative review. Journal Health Inequalities. 2024;10(1):56-63. doi:10.5114/jhi.2024.140767. APA Kawecka, P., & Kostecka, (2024). Inequalities, 10(1), 56-63. https://doi.org/10.5114/jhi.2024.140767 Chicago Paulina, Małgorzata Kostecka. 2024. "The review". Inequalities 10 (1): Harvard pp.56-63. MLA Paulina et al. review." vol. 10, no. 1, 2024, pp. Vancouver

Language: Английский

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