Oxidative stress‐A direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease DOI
Mai M. Anwar

Cell Biochemistry and Function, Journal Year: 2021, Volume and Issue: 40(1), P. 17 - 27

Published: Oct. 30, 2021

Neurologists have highly observed a frequent increasing number of elderly patients with Alzheimer's disease (AD) without any relevant evidence genetic or known AD‐linked predisposing factors in the past few years. Those are characterized by continuous and irreversible neuron cells loss along declined cognitive functions. Numerous studies suggested that exaggerated release reactive oxygen species (ROS) within brain may develop late‐onset neurodegenerative disorders, especially AD‐neuroinflammatory type. However, central nervous system is vitally linked whole‐brain chemical integrity its related healthy state, cascade which ROS result AD's development has not been justified even maintained. It widely consumes vast amount being rich lipid polyunsaturated fatty acids content, explaining why it prone region to oxidative stress (OS) damage. The formed OS‐AD cytoskeletal protein aggregates can be considered main factor for amyloid‐beta (Aβ) hallmarks precipitation. Herein, this review aims provide detailed information on how play pathogenic role activating damage‐associated molecular patterns (DAMPs)–related toll‐like receptor‐4 inflammatory (TLR‐4) cascades resulting deposition Aβ tissues ending dysfunction. also explains microglia activated via ROS, significantly several pro‐inflammatory general atrophy. Furthermore, different types antioxidant therapies will discussed combat AD‐related pathological disorders hallmarks.

Language: Английский

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs DOI
Giuseppe Cirino, Csaba Szabó, Andreas Papapetropoulos

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 31 - 276

Published: April 18, 2022

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous regulator of a broad range physiological functions. H2S belongs to class molecules known gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Three enzymes are recognized sources in various cells tissues: cystathionine γ-lyase (CSE), β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST). The present article reviews regulation these well pathways their enzymatic nonenzymatic degradation elimination. multiple interactions with other labile (e.g., NO) reactive oxygen species also outlined. Next, biological targets signaling outlined, special reference or oxidative posttranscriptional modification (persulfidation sulfhydration) proteins effect on channels intracellular second messenger pathways, gene transcription translation, cellular bioenergetics metabolism. pharmacological molecular tools currently available study physiology reviewed, including utility limitations. In subsequent sections, role functions is membrane potential, endo- exocytosis, cell organelles (endoplasmic reticulum, Golgi, mitochondria), movement, cycle, differentiation, aspects regulated death. roles types organ systems overviewed, red blood cells, immune central peripheral nervous (with focus neuronal transmission, learning, memory formation), vascular function (including angiogenesis its specialized cerebrovascular, renal, pulmonary beds) senses, vision, hearing, taste smell, pain-sensing. Finally, (lung, heart, liver, kidney, urogenital organs, reproductive system, bone cartilage, skeletal muscle, endocrine organs) presented, aging) but extending some common pathophysiological conditions. From data, wide array significant all emerges characteristic bell-shaped biphasic effects highlighted. addition, key aspects, debated areas, future research translational areas identified.

Language: Английский

Citations

289
Hydrogen Sulfide Biology and Its Role in Cancer DOI Creative Commons
Saadullah Khattak, Mohd Ahmar Rauf, Nazeer Hussain Khan

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3389 - 3389

Published: May 25, 2022

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role many pathophysiological processes the body. can be endogenously through enzymes analogous to cysteine family, while exogenous source may involve inorganic salts. H2S has recently been well investigated with regard onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. considered oncogenic gas, potential therapeutic target for treating diagnosing cancers, due its mediating development tumorigenesis. Here this review, in-detail up-to-date explanation different malignancies reported. The study summarizes synthesis H2S, roles, signaling routes, expressions, release malignancies. Considering importance biological molecule, we believe review esteemed journal will highlight scientific community.

Language: Английский

Citations

82
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species DOI Creative Commons

Jun Uchiyama,

Masahiro Akiyama, Koji Hase

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 38(10), P. 110479 - 110479

Published: March 1, 2022

Gut microbiota act beyond the gastrointestinal tract to regulate physiology of host. However, their contribution antioxidant capacity host remains largely understudied. In this study, we observe that gut bacteria increase steady-state plasma levels high-antioxidant molecules, reactive sulfur species (RSS), such as hydrogen sulfide and cysteine persulfide (CysSSH), in Moreover, utilize cystine a substrate enzymatically produce CysSSH. Administration mice increases RSS suppresses concanavalin-A-induced oxidative stress liver damage gut-microbiota-dependent manner. We find belonging Lachnospiraceae Ruminococcaceae families have high RSS, requiring pyridoxal 5′-phosphate for enzymatic reactions. Collectively, our data demonstrate enhance through generation RSS.

Language: Английский

Citations

71
Hydrogen sulfide (H2S) metabolism: Unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine DOI
Tejasvi Pandey, Vivek Pandey

Nitric Oxide, Journal Year: 2024, Volume and Issue: 144, P. 20 - 28

Published: Jan. 17, 2024

Language: Английский

Citations

23
Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease DOI Creative Commons

Ruibing Li,

Sam Toan, Hao Zhou

et al.

Aging, Journal Year: 2020, Volume and Issue: 12(7), P. 6467 - 6485

Published: March 26, 2020

Nutrient oversupply and mitochondrial dysfunction play central roles in nonalcoholic fatty liver disease (NAFLD).The mitochondria are the major sites of β-oxidation, a catabolic process by which acids broken down.The quality control (MQC) system includes fission, fusion, mitophagy redox regulation, is essential for maintenance functionality structural integrity mitochondria.Excessive uncontrolled production reactive oxygen species (ROS) damages components, including membranes, proteins DNA (mtDNA), triggers pathway apoptosis.The some damaged can be restored fusion with normally functioning mitochondria, but when severely damaged, segregated from remaining functional network through fission eventually degraded via autophagy, also called as mitophagy.In this review, we describe functions mechanisms oxidative stress development progression NAFLD.

Language: Английский

Citations

72
ROS-Induced mtDNA Release: The Emerging Messenger for Communication between Neurons and Innate Immune Cells during Neurodegenerative Disorder Progression DOI Creative Commons
Yuanxin Zhao,

Buhan Liu,

Long Xu

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(12), P. 1917 - 1917

Published: Nov. 29, 2021

One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis, is microglia-mediated astrocyte-mediated neuroinflammation. Although inhibitions both harmful proteins aggregation are major treatments for whether phenomenon non-normal protein or peptide causally related to neuronal loss synaptic damage still controversial. Currently, excessive production reactive oxygen species (ROS), which induces mitochondrial dysfunction in neurons that may play a key role regulation immune cells, proposed as regulator neurological disorders. In this review, we propose DNA (mtDNA) release due ROS act on microglia astrocytes adjacent induce inflammation through activation innate responses (such cGAS/STING). Elucidating relationship between mtDNA formation pro-inflammatory microenvironment could contribute better understanding mechanism crosstalk peripheral cells lead development novel therapeutic approaches diseases.

Language: Английский

Citations

65
Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways DOI

Tian Jin,

Yong Zhang, Benson O. A. Botchway

et al.

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 164, P. 113091 - 113091

Published: May 6, 2022

Language: Английский

Citations

65
Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities DOI Open Access
Emmanuel Ayodeji Ayeni, Ahmad M. Aldossary, Daniel A. Ayejoto

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(19), P. 12495 - 12495

Published: Sept. 30, 2022

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative (NDDs) increases with age. Neuronal hormones neurotransmitters determinant factors regulating brain structure functions. The implications of environmental climatic changes emerged recently as influence on numerous diseases. However, the complex interaction neuronal their depletion under influences NDDs not well established in literature. In this review, we aim explore connection between highlight available potential therapeutic interventions that could use improve quality life reduce susceptibility NDDs.

Language: Английский

Citations

57
Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects DOI

Chuanqi Chu,

Leilei Yu, Guoyuan Qi

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104556 - 104556

Published: Feb. 3, 2022

Language: Английский

Citations

55
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease DOI Creative Commons
Swetha Pavani Rao, Prakashkumar Dobariya,

Harshini Bellamkonda

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 603 - 603

Published: March 1, 2023

3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well cytoplasm. 3-MST mediates reaction with dihydrolipoic acid and thioredoxin produce Hydrogen sulfide also produced through cystathionine beta-synthase gamma-lyase, along 3-MST, known alleviate a variety illnesses such cancer, heart disease, neurological conditions. The importance gamma-lyase biogenesis well-described, but documentation pathway limited. This account compiles current state knowledge about physiology pathology. Attempts at targeting for therapeutic benefit are discussed, highlighting potential target.

Language: Английский

Citations

27