Journal of Tissue Engineering,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 1, 2025
Atopic
dermatitis
(AD)
is
a
chronic
relapsing
dermatosis
that
demands
new
therapies.
This
research
group
previously
developed
physically
extracted
adipose-derived
extracellular
matrix
named
adipose
collagen
fragments
(ACF),
which
was
determined
containing
massive
matrix-bound
adipokines
and
medicable
on
AD
through
intradermal
injection.
However,
problems
concerning
the
control
of
drug
release
inevitable
pain
caused
by
injection
hinder
application
ACF
in
clinics.
Microneedle
(MN)
rapid
developing
technique
for
precise
painless
transdermal
delivery.
Therefore,
dissolving
methacrylated
gelatin/hyaluronic
acid
MN
patch
loaded
with
this
study.
The
morphological
characteristics,
mechanical
properties,
penetration
ability,
as
well
biocompatibility
degradation
efficiency
ACF-MN
were
evaluated,
its
efficacy
ovalbumin-induced
mice
also
investigated.
exhibited
excellent
biocompatibility,
efficiency,
satisfying
murine
similar
fresh-made
ACF.
Furthermore,
RNA-Seq
combining
bioinformatics
performed
mechanism
exploration.
treatment
showed
comprehensive
via
restoring
inflammatory
dysregulation,
microbiota
imbalance,
skin
barrier
defects.
study
offered
novel
MN-based
ACF-bound
delivery
system
may
serve
promising
strategy
relieving
AD.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
62(10)
Published: Dec. 7, 2022
Protein
and
peptide
drugs
are
predominantly
administered
by
injection
to
achieve
high
bioavailability,
but
this
greatly
compromises
patient
compliance.
Oral
transdermal
drug
delivery
with
minimal
invasiveness
adherence
represent
attractive
alternatives
administration.
However,
oral
administration
of
bioactive
proteins
must
overcome
biological
barriers,
namely
the
gastrointestinal
skin
respectively.
The
rapid
development
new
materials
technologies
promises
address
these
physiological
obstacles.
This
review
provides
an
overview
latest
advances
in
protein
delivery,
including
chemical
strategies,
synthetic
nanoparticles,
medical
microdevices,
biomimetic
systems
for
administration,
as
well
enhancers,
physical
approaches,
microneedles
delivery.
We
also
discuss
challenges
future
perspectives
field
a
focus
on
innovation
translation.
Materials & Design,
Journal Year:
2022,
Volume and Issue:
224, P. 111363 - 111363
Published: Nov. 10, 2022
Psoriasis
is
a
chronic
scaly
skin
disease,
which
associated
with
abnormal
immune
system
function,
inflammatory
cell
infiltration.
The
disadvantages
of
traditional
treatment
psoriasis
are
poor
efficacy,
recurrence
the
condition,
long
time,
and
systemic
side
effects
due
to
lack
an
appropriate
drug
delivery
system.
A
liposome-in-Microneedles
(MNs)
based
transdermal
had
been
developed
provide
efficient
site-specific
delivery,
stable
release
enhanced
permeability.
Firstly,
liposomes
were
loaded
Ginsenoside
Rg3
(a
small
molecular
compound
anti-inflammatory
regulation
functions),
then
Rg3-liposomes
(Rg3-Lipo)
successfully
into
MNs.
Rg3-Liposome-MNs
(Rg3-MNs)
mechanical
property
0.59
N/needle,
could
easily
penetrate
epidermis
Rg3-lipo
regulate
response.
efficacy
Rg3-MNs
was
evaluated
by
IMQ-induced
psoriasis-like
dermatitis
in
mice.
significantly
(p
<
0.01)
decreased
epidermal
thickness,
dermal
papillary
edema,
possible
mechanism
markedly
reduce
levels
IL-17,
IL-23,
TNF-α.
In
addition,
we
found
that
might
improve
inhibiting
activation
STAT3/p-STAT3
signaling
pathway.
brief,
this
study
provides
ideal
immunoregulatory
treat
psoriasis.
Frontiers in Drug Delivery,
Journal Year:
2022,
Volume and Issue:
2
Published: Sept. 5, 2022
Recent
advances
in
topical
and
transdermal
drug
delivery
systems
have
enabled
targeted
of
therapeutics
to
the
site
action
by
enhancing
permeation
across
stratum
corneum
increased
bioavailability.
Despite
various
technological
advancements,
some
dermatoses
still
limited
treatment
options
due
potential
adverse
effects
challenges
formulation
development.
To
address
limitations
posed
conventional
dermatotherapy,
nano-based
technologies
been
developed
demonstrated
a
significant
improvement
dermatotherapy.
Their
distinct
physicochemical
properties
demonstrate
their
overall
superior
therapeutic
efficacy
providing
sustained
effective
release,
as
well
improved
solubility
hydrophobic
actives
with
optimized
formulations.
These
nanocarriers
are
commonly
classified
polymeric,
lipid-based,
metallic,
vesicular
nanocarriers,
including
nanoemulsions,
nanofibers,
microneedles.
This
mini-review
aims
recent
technologies,
brief
insight
on
current
prospective
approaches
aimed
at
improving
delivery.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2165 - 2165
Published: Aug. 21, 2023
Skin
diseases
are
among
the
most
prevalent
non-fatal
conditions
worldwide.
The
transdermal
drug
delivery
system
(TDDS)
has
emerged
as
a
promising
approach
for
treating
skin
diseases,
owing
to
its
numerous
advantages
such
high
bioavailability,
low
systemic
toxicity,
and
improved
patient
compliance.
However,
effectiveness
of
TDDS
is
hindered
by
several
factors,
including
barrier
properties
stratum
corneum,
nature
carrier,
conditions.
In
this
paper,
we
provide
an
overview
development
from
first-generation
fourth-generation
systems,
highlighting
characteristics
each
carrier
in
terms
mechanism
composition,
penetration
method,
action,
recent
preclinical
studies.
We
further
investigated
significant
challenges
encountered
crucial
significance
clinical
trials.
Burns & Trauma,
Journal Year:
2023,
Volume and Issue:
11
Published: Jan. 1, 2023
The
prevention
and
treatment
of
pathological
scars
remain
challenging.
Corticosteroids
are
the
mainstay
drugs
in
clinical
scar
as
they
effectively
induce
regression
improve
pruritus
pain.
Currently,
intralesional
injections
corticosteroids
widely
used
practice.
These
require
professional
medical
manipulation;
however,
significant
accompanying
injection
pain,
repetition
adverse
effects,
such
skin
atrophy,
pigmentation
telangiectasia,
make
this
modality
an
unpleasant
experience
for
patients.
Transdermal
administration
is,
therefore,
a
promising
non-invasive
easy-to-use
method
corticosteroid
treatment.
In
review,
we
first
summarize
mechanisms
action
treatment;
then,
discuss
current
developments
progress
transdermal
delivery
systems
corticosteroids,
well
their
corresponding
advantages
disadvantages.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115316 - 115316
Published: Aug. 10, 2023
Melanoma
is
a
highly
aggressive
form
of
skin
cancer
with
limited
therapeutic
options.
Chemo-photothermal
combination
therapy
has
demonstrated
potential
for
effectively
treating
melanoma,
and
transdermal
administration
considered
the
optimal
route
diseases
due
to
its
ability
bypass
first-pass
metabolism
enhance
drug
concentration.
However,
stratum
corneum
presents
formidable
challenge
as
significant
barrier
penetration
in
delivery.
Lipid-nanocarriers,
particularly
cubosomes,
have
been
possess
augmenting
permeation
across
corneum.
Herein,
cubosomes
co-loaded
doxorubicin
(DOX,
chemotherapeutic
drug)
indocyanine
green
(ICG,
photothermal
agent)
(DOX-ICG-cubo)
delivery
system
was
developed
efficiency
melanoma
by
improving
permeation.
The
DOX-ICG-cubo
showed
high
encapsulation
both
DOX
ICG,
exhibited
good
stability
under
physiological
conditions.
In
addition,
unique
cubic
structure
confirmed
through
transmission
electron
microscopy
(TEM)
images,
polarizing
microscopy,
small
angle
X-ray
scattering
(SAXS).
presented
conversion
efficiency,
well
pH
thermo-responsive
release.
Notably,
enhanced
biocompatibility,
improved
vivo
anti-melanoma
efficacy
synergistic
effects
chemo-photothermal
therapy.
conclusion,
promising
strategy
treatment.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(16), P. 3807 - 3839
Published: Jan. 1, 2024
This
review
article
explores
the
innovative
field
of
eco-friendly
cyclodextrin-based
coordination
polymers
and
metal-organic
frameworks
(MOFs)
for
transdermal
drug
delivery
in
case
skin
cancer
therapy.
We
critically
examine
significant
advancements
developing
these
nanocarriers,
with
a
focus
on
their
unique
properties
such
as
biocompatibility,
targeted
release,
enhanced
permeability.
These
attributes
are
instrumental
addressing
limitations
inherent
traditional
treatments
represent
paradigm
shift
towards
more
effective
patient-friendly
therapeutic
approaches.
Furthermore,
we
discuss
challenges
faced
optimizing
synthesis
process
large-scale
production
while
ensuring
environmental
sustainability.
The
also
emphasizes
immense
potential
clinical
applications
nanocarriers
therapy,
highlighting
role
facilitating
targeted,
controlled
release
which
minimizes
systemic
side
effects.
Future
could
see
being
customized
to
individual
patient
profiles,
potentially
revolutionizing
personalized
medicine
oncology.
With
further
research
trials,
hold
promise
transforming
landscape
treatment.
this
study,
aim
provide
comprehensive
overview
current
state
outline
future
directions
advancing
development
application
nanocarriers.
