Abstract
Commencing
with
the
breakdown
of
diabetic
osteoimmune
microenvironment,
multiple
pathogenic
factors,
including
hyperglycemia,
inflammation,
hypoxia,
and
deleterious
cytokines,
are
conjointly
involved
in
progression
periodontal
bone
regeneration.
Based
on
challenge
regeneration
treatment
absence
real‐time
feedback
blood
oxygen
fluctuation
diabetes
mellitus,
a
novel
self‐adaptive
hyperthermia
supramolecular
cascade
nano‐reactor
ACFDG
is
constructed
via
one‐step
self‐assembly
strategy
to
address
factors
Hyperthermia
possesses
high
photothermal
conversion
efficiency
(32.1%),
it
can
effectively
inhibit
vicious
cycle
ROS‐inflammatory
through
catalytic
reactions,
up‐regulate
expression
heat
shock
proteins
(HSPs)
under
near‐infrared
(NIR)
irradiation,
which
promotes
Remarkably,
provide
non‐invasive
diagnosis
changes
during
photoacoustic
(PA)
imaging,
thus
timely
monitor
hypoxia
status.
In
conclusion,
this
multifunctional
combined
PA
imaging
for
efficacy
monitoring
provides
important
insights
into
biological
mechanisms
potential
clinical
theranostics.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(16)
Опубликована: Март 2, 2024
Hybrid
nanomaterials
have
found
use
in
many
biomedical
applications.
This
article
provides
a
comprehensive
review
of
the
principles,
techniques,
and
recent
advancements
design
fabrication
hybrid
for
biomedicine.
We
begin
with
an
introduction
to
general
concept
material
hybridization,
followed
by
discussion
how
this
approach
leads
materials
additional
functionality
enhanced
performance.
then
highlight
forms
nanostructures,
nanocomposites,
metal-organic
frameworks,
biohybrids,
including
their
methods.
also
showcase
advance
engineering
context
nanomedicine,
regenerative
medicine,
diagnostics,
theranostics,
biomanufacturing.
Finally,
we
offer
perspectives
on
challenges
opportunities.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Март 20, 2024
Diabetic
wounds
are
susceptible
to
bacterial
infections,
largely
linked
high
blood
glucose
levels
(hyperglycemia).
To
treat
such
wounds,
enzymes
like
oxidase
(GOx)
can
be
combined
with
nanozymes
(nanomaterials
mimic
enzymes)
use
effectively
for
purposes.
However,
there
is
still
room
improvement
in
these
systems,
particularly
terms
of
process
simplification,
enzyme
activity
regulation,
and
treatment
effects.
Herein,
the
approach
utilizes
GOx
directly
facilitate
biomineralized
growth
osmium
(Os)
nanozyme
(GOx-OsNCs),
leading
dual-active
centers
remarkable
triple
activities.
Initially,
GOx-OsNCs
vicinal
centers,
enabling
a
self-cascaded
mechanism
that
significantly
enhances
sensing
performance
compared
step-by-step
reactions,
surpassing
capabilities
other
metal
sources
as
gold
platinum.
In
addition,
integrated
into
glucose-sensing
gel,
instantaneous
visual
feedback.
infected
diabetic
exhibit
multifaceted
benefits
by
lowering
exhibiting
antibacterial
properties
through
generation
hydroxyl
free
radicals,
thereby
expediting
healing
fostering
favorable
microenvironment.
Furthermore,
catalase-like
aids
reducing
oxidative
stress,
inflammation,
hypoxia,
culminating
improved
outcomes.
Overall,
this
synergistic
enzyme-nanozyme
blend
user-friendly
holds
considerable
promise
diverse
applications.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 131277 - 131277
Опубликована: Март 31, 2024
Bacteria-infected
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
Wound
dressing
is
a
potential
strategy
for
repairing
infectious
wounds.
However,
the
development
of
with
appropriate
physiochemical,
antibacterial,
and
hemostatic
properties,
remains
challenging.
Hence,
there
motivation
to
develop
new
synthetic
dressings
improve
bacteria-infected
healing.
Here,
we
fabricate
biocompatible
sponge
through
covalent
crosslinking
collagen
(Col),
quaternized
chitosan
(QCS),
graphene
oxide
(GO).
The
resulting
Col-QCS-GO
shows
an
elastic
modulus
1.93-fold
higher
than
Col
due
enhanced
degree
by
GO
incorporation.
Moreover,
fabricated
favorable
porosity
(84.30
±
3.12
%),
water
absorption/retention
(2658.0
113.4
%/1114.0
65.7
hemostasis
capacities
(blood
loss
<50.0
mg).
Furthermore,
antibacterial
property
under
near-infrared
(NIR)
irradiation
significantly
(the
inhibition
rates
are
99.9
%
S.
aureus
E.
coli)
inherent
properties
QCS
photothermal
capabilities
GO.
Finally,
Col-QCS-GO+NIR
exhibits
lowest
percentage
area
(9.05
1.42
%)
at
day
14
compared
control
group
(31.61
1.76
%).
This
study
provides
insights
developing
innovative
sponges
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Май 27, 2024
Abstract
Biofilm‐associated
infections
pose
complex
challenges
that
require
addressing
the
multifaceted
requirements
of
biofilm
disruption,
bacterial
killing,
and
immunomodulation.
In
this
study,
microenvironment‐adaptive
metallo‐polymeric
nanodecoys
(MPNs)
are
synthesized
through
one‐pot
subcomponent
coordination
in
aqueous
solution,
effectively
eradicating
biofilms
modulating
immune
response.
Within
acidic
microenvironment
biofilms,
positively
charged
MPNs
demonstrated
ability
to
interact
with
eliminate
bacteria
while
facilitating
a
Fenton‐like
reaction
for
efficient
eradication
biofilms.
As
local
shifted
from
neutral
basic
state
during
subsequent
tissue
healing
processes,
adaptively
harness
multiple
properties
bind
pathogen‐associated
molecular
patterns,
scavenge
reactive
oxygen
species,
thereby
response,
alleviating
inflammation,
promoting
healing.
This
study
presents
an
strategy
preparing
enzyme‐mimicking
materials
closely
resemble
natural
metalloenzymes,
offer
alternative
current
antibiotic
treatments
biofilm‐associated
infections.
ACS Nano,
Год журнала:
2024,
Номер
18(18), С. 11988 - 12009
Опубликована: Апрель 23, 2024
Periodontitis,
a
chronic
oral
disease
instigated
by
bacteria,
severely
compromises
human
health.
The
prevailing
clinical
treatment
for
periodontitis
involves
mechanical
scraping
in
conjunction
with
antibiotics.
Phototherapy
is
employed
to
rapidly
remove
the
bacteria
and
achieve
treatment,
effectively
circumventing
adverse
effects
associated
traditional
therapies.
Constructing
2D/2D
van
der
Waals
(VDW)
heterojunctions
key
strategy
obtaining
excellent
photocatalytic
activity.
Herein,
violet
phosphorus
(VP)/Ti
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(3), С. 3215 - 3231
Опубликована: Янв. 11, 2024
Biofilm-associated
infections
(BAIs)
have
been
considered
a
major
threat
to
public
health,
which
induce
persistent
and
serious
complications.
The
poor
penetration
of
antibacterial
agents
in
biofilm
significantly
limits
the
efficiency
combating
BAIs.
Magnetic
urchin-like
core–shell
nanospheres
Fe3O4@Bi2S3
were
developed
for
physically
destructing
inducing
bacterial
eradication
via
reactive
oxygen
species
(ROS)
generation
innate
immunity
regulation.
magnetic
with
sharp
edges
exhibited
propeller-like
rotation
destroy
under
rotating
field
(RMF).
mild
hyperthermia
improved
ROS
enhanced
eradication.
Significantly,
nanostructure
generated
could
stimulate
macrophage
polarization
toward
M1
phenotype,
eradicate
bacteria
metabolic
inactivity
state
through
phagocytosis,
thereby
promoting
recovery
implant
infection
inhibiting
recurrence.
Thus,
design
magnetic-driven
sharp-shaped
nanostructures
provided
enormous
potential
infections.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(14)
Опубликована: Фев. 14, 2024
Oral
wound
treatment
faces
challenges
due
to
the
complex
oral
environment,
thus,
sealing
quickly
becomes
necessary.
Although
some
materials
have
achieved
adhesion
and
sterilization,
how
effectively
solve
contradiction
between
strong
on-demand
removal
remains
a
challenge.
Herein,
reversibly
adhesive
hydrogel
is
designed
by
free
radical
copolymerization
of
cationic
monomer
[2-(acryloyloxy)
ethyl]
trimethylammonium
chloride
(ATAC),
hydrophobic
ethylene
glycol
phenyl
ether
acrylate
(PEA)
N-isopropylacrylamide
(NIPAAm).
The
quaternary
ammonium
salts
provide
electrostatic
interactions,
groups
PNIPAAm
chain
segments
hydrogen
bonding,
leading
adhesion.
Therefore,
obtains
an
strength
18.67
KPa
mucosa
can
seal
wounds
fast
within
10
s.
Furthermore,
unlike
pure
PNIPAAm,
has
lower
critical
solution
temperature
40.3
°C
contribution
ATAC
PEA,
enabling
rapid
with
40
water
after
treatment.
In
addition,
realizes
excellent
anti-swelling
ratio
(≈80%)
antibacterial
efficiency
(over
90%).
Animal
experiments
prove
that
reduces
inflammation
infiltration,
promotes
collagen
deposition
vascular
regeneration.
Thus,
as
multi-functional
dressing
great
application
prospects
in
management.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(16)
Опубликована: Март 2, 2024
Abstract
Hybrid
nanomaterials
have
found
use
in
many
biomedical
applications.
This
article
provides
a
comprehensive
review
of
the
principles,
techniques,
and
recent
advancements
design
fabrication
hybrid
for
biomedicine.
We
begin
with
an
introduction
to
general
concept
material
hybridization,
followed
by
discussion
how
this
approach
leads
materials
additional
functionality
enhanced
performance.
then
highlight
forms
nanostructures,
nanocomposites,
metal–organic
frameworks,
biohybrids,
including
their
methods.
also
showcase
advance
engineering
context
nanomedicine,
regenerative
medicine,
diagnostics,
theranostics,
biomanufacturing.
Finally,
we
offer
perspectives
on
challenges
opportunities.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(6), С. 3673 - 3692
Опубликована: Май 8, 2024
Copper
(Cu)
and
Cu-based
nanomaterials
have
received
tremendous
attention
in
recent
years
because
of
their
unique
physicochemical
properties
good
biocompatibility
the
treatment
various
diseases,
especially
cancer.
To
date,
researchers
designed
fabricated
a
variety
integrated
nanocomplexes
with
distinctive
nanostructures
applied
them
cancer
therapy,
mainly
including
chemotherapy,
radiotherapy
(RT),
photothermal
therapy
(PTT),
chemodynamic
(CDT),
photodynamic
(PDT),
cuproptosis-mediated
etc.
Due
to
limited
effect
single
method,
development
composite
diagnostic
nanosystems
that
integrate
PTT,
CDT,
PDT,
other
treatments
is
great
significance
offers
potential
for
next
generation
anticancer
nanomedicines.
In
view
rapid
field
this
review
focuses
on
current
state
research
nanomaterials,
followed
by
discussion
combined
therapy.
Moreover,
challenges
future
prospects
clinical
translation
are
proposed
provide
some
insights
into
design
nanotherapeutic
platforms.
