ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(13), С. 15446 - 15458
Опубликована: Июнь 26, 2024
In
recent
years,
the
application
of
hollow
mesoporous
silicon
nanoparticles
in
biomedical
field
has
attracted
much
attention
because
their
excellent
features.
this
study,
sonosensitizer
curcumin
(Cur),
chemotherapy
drug
doxorubicin
(Dox),
and
perfluoropropane
(C3F8)
gas
were
loaded
into
a
multifunctional
silica
nanoparticle
(MHMSN).
The
surface
MHMSN
was
modified
with
biotin
molecule
acid-sensitive
groups
(cis-aconitic
anhydride-polyethylene
glycol,
CDM-PEG).
as-prepared
(CDF-MHMSN)
demonstrates
improved
therapeutic
efficacy
enhanced
tumor
contrast
ultrasound
performance.
Surface-modified
CDM-PEG
can
improve
blood
circulation
ability
peel
off
acidic
microenvironment,
which
enhance
endocytosis
cancer
cells.
As
sonosensitizer,
Cur
could
generate
reactive
oxygen
species
(ROS)
under
stimulation
to
kill
cells
reduce
multidrug
resistance
Dox
by
inhibiting
expression
P-glycoprotein.
Overall,
CDF-MHMSN
exhibits
good
biocompatibility,
imaging
capability,
effective
antitumor
ability,
may
contribute
improving
treatment
strategy
for
hepatocellular
carcinoma.
Immunogenic
cell
death
(ICD,
also
known
as
immunogenic
apoptosis)
of
malignant
cells
is
confirmed
to
activate
the
host
immune
system
prevent,
control,
and
eliminate
tumors.
Recently,
a
range
chemotherapeutic
drugs
have
been
repurposed
ICD
inducers
applied
for
tumor
immunotherapy.
However,
several
hurdles
widespread
application
remain,
namely
poor
water
solubility,
short
blood
circulation,
non-specific
tissue
distribution,
severe
toxicity.
Recent
advances
in
nanotechnology
pharmaceutical
formulation
foster
development
nano
drug
delivery
systems
tackle
aforementioned
expedite
safe,
effective,
specific
delivery.
This
review
will
describe
barriers
chemical
highlight
recent
nanoformulations
these
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
654, С. 123976 - 123976
Опубликована: Март 6, 2024
As
cancer
being
the
most
difficult
disease
to
treat,
different
kinds
of
medications
and
therapeutic
approaches
have
been
prominently
developed
by
scientists.
For
certain
families
drugs,
such
as
immuno-therapeutics
or
antibody-drug
conjugates,
efficient
delivery
systems
are
required
during
administration
protect
drugs
from
chemical
degradation
biological
inactivation.
Delivery
with
ability
carry
therapeutics
diagnostic
agents
both,
hold
promising
potential
tackle
abnormalities
behind
cancer.
In
this
context,
review
provides
updated
insights
on
how
cyclodextrin-based
polymeric
nanosystems
become
an
effective
treatment
approach
against
Cyclodextrins
(CDs)
natural
oligosaccharides
that
famously
exploited
in
pharmaceutical
research
due
their
exceptional
quality
entrapping
water-insoluble
molecules
inside
hydrophobic
core
providing
enhanced
solubility
help
hydrophilic
exterior.
Combining
properties
CDs
nanoparticles
(PNPs)
brings
out
excellent
versatile
tunable
profiles,
thanks
submicron-sized
PNPs.
By
introducing
significance
CD
a
system,
collective
discussion
binding
release
mechanisms
CD-drug
complexation,
followed
characterization
studies
has
done
review.
Further,
light
recent
studies,
article
majorly
focuses
conveying
promoting
nanoscale
elevates
multifunctional
advantages
can
be
successfully
applied
combination
therapy
theranostics.
Moreover,
CD-based
including
CALAA-01,
CRLX101,
CRLX301,
demonstrated
improved
tumor
targeting,
reduced
side
effects,
prolonged
drug
preclinical
clinical
trials.
Current Medical Research and Opinion,
Год журнала:
2024,
Номер
40(11), С. 1943 - 1961
Опубликована: Окт. 16, 2024
The
development
of
therapies
followed
a
generalized
approach
for
long
time,
assuming
that
single
treatment
could
effectively
address
various
patient
populations.
However,
recent
breakthroughs
have
revealed
the
limitations
this
one-size-fits-all
paradigm.
More
recently,
field
therapeutics
has
witnessed
shift
toward
other
modules,
including
cell
therapies,
high
molecular
weight
remedies,
personalized
medicines,
and
gene
therapies.
Such
advancements
in
therapeutic
modules
potential
to
revolutionize
healthcare
pave
way
medicines
are
more
efficient
with
minimal
side
effects.
Cell
gained
considerable
attention
regenerative
medicine.
Stem
cell-based
instance,
hold
promise
tissue
repair
regeneration,
ongoing
research
focusing
on
enhancing
their
efficacy
safety.
High
drugs
like
peptides
proteins
emerged
as
promising
because
specificity
diverse
biological
functions.
Engineered
developed
targeted
drug
delivery,
immunotherapy,
disease-modulation.
In
medicine,
tailored
treatments
individuals
based
specific
genetic
profiling,
lifestyle,
biomarkers,
disease
characteristics
all
implemented.
Clinicians
optimize
outcomes
minimize
adverse
effects,
using
mutations,
yielding
remarkable
results.
Gene
revolutionized
disorders
by
directly
targeting
underlying
abnormalities.
Innovative
techniques,
such
CRISPR-Cas9
allowed
precise
editing,
opening
up
possibilities
curing
previously
incurable
conditions.
conclusion,
Bioactive Materials,
Год журнала:
2024,
Номер
37, С. 30 - 50
Опубликована: Март 14, 2024
As
an
endogenous
signaling
molecule,
carbon
monoxide
(CO)
has
emerged
as
increasingly
promising
option
regarding
gas
therapy
due
to
its
positive
pharmacological
effects
in
various
diseases.
Owing
the
gaseous
nature
and
potential
toxicity,
it
is
particularly
important
modulate
CO
release
dosages
targeted
locations
elucidate
biological
mechanisms
of
facilitate
clinical
applications.
Based
on
these,
diverse
CO-releasing
molecules
(CORMs)
have
been
developed
for
controlled
systems.
However,
practical
applications
these
CORMs
are
limited
by
several
disadvantages
including
low
stability,
poor
solubility,
weak
releasing
controllability,
random
diffusion,
toxicity.
In
light
rapid
developments
advantages
nanomedicine,
abundant
nanomaterials
ways
therapeutic
purposes
across
Due
their
nanoscale
sizes,
diversified
compositions
modified
surfaces,
vast
(CORNMs)
constructed
exhibited
specific
under
stimuli
with
better
pharmacokinetics
pharmacodynamics.
this
review,
we
present
recent
progress
CORNMs
according
compositions.
Following
a
concise
introduction
therapy,
CORNMs,
representative
research
from
organic
nanostructures,
hybrid
nanomaterials,
inorganic
nanocomposites
elaborated.
The
basic
properties
such
active
components,
mechanisms,
detection
methods,
applications,
discussed
detail
listed
table.
Finally,
explore
discuss
prospects
challenges
associated
utilizing
release.
Nanoscale,
Год журнала:
2023,
Номер
15(36), С. 14698 - 14716
Опубликована: Янв. 1, 2023
Pancreatic
cancer
is
a
devastating
disease
with
low
survival
rate
and
limited
treatment
options
in
this
context,
multifunctional
graphene
quantum
dot-based
receptor
targeting,
drug
delivery,
bioimaging
possess
immense
potential
to
cure
pancreatic
cancer.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
157, С. 113998 - 113998
Опубликована: Ноя. 16, 2022
Cancer
immunotherapy
is
a
therapeutic
strategy
to
inhibit
tumor
growth
and
metastasis
by
intervening
in
the
immune
response
process.
Strategies
applied
cancer
mainly
include
blocking
checkpoints,
adoptive
transfer
of
engineered
cells,
cytokine
therapy,
vaccines,
oncolytic
virus
infection.
However,
many
factors,
such
as
off-target
side
effects,
immunosuppressive
cell
infiltration
and/or
upregulation
checkpoint
expression,
heterogeneity,
lack
antigen
presentation,
affect
effect
on
cancer.
To
improve
efficacy
targeted
reduce
over
past
two
decades,
nanoparticle
delivery
platforms
have
been
increasingly
used
immunotherapy.
nanoparticles
are
still
subject
biological
barriers
biodistribution
challenges,
which
limit
their
overall
clinical
potential.
This
has
prompted
series
overcome
specific
obstacles
accumulation
payloads
tumor-infiltrating
cells.
In
recent
years,
new
techniques
chemical
methods
employed
modify
or
functionalize
surfaces
nanoparticles.
review
discusses
progress
surface-engineered
inducing
responses
immunotherapy,
well
future
directions
for
development
next-generation
nanomedicines.
