Nanoscale, Год журнала: 2024, Номер 16(16), С. 7892 - 7907
Опубликована: Янв. 1, 2024
Anaerobic bacteria deliver anisotropic magnetic nanocarriers to hard-to-reach hypoxic tumor cores. The enhanced heating effect at the cores of tumors acts as a smart therapeutic approach for improved hyperthermia-based cancer therapy.
Язык: Английский
Pharmacological Research, Год журнала: 2021, Номер 171, С. 105780 - 105780
Опубликована: Июль 21, 2021
Язык: Английский
Процитировано
448
Chemical Society Reviews, Год журнала: 2021, Номер 50(20), С. 11614 - 11667
Опубликована: Янв. 1, 2021
Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that has now accumulated more than 30 years experience. In ongoing MHT clinical trials brain and prostate tumors, iron oxide nanoparticles are employed as intra-tumoral agents under patient-safe 100 kHz alternating magnetic field (AMF) applicator. Although currently approved by FDA imaging purposes anemia, (MNPs) designed efficient must respond to specific physical-chemical properties in terms magneto-energy conversion, heat dose production, surface chemistry aggregation state. Accordingly, past few decades, these requirements have boosted development new generation MNPs specifically aimed MHT. this review, we present an overview on their assemblies produced via different synthetic routes, focusing which MNP features allowed unprecedented heating efficiency levels be achieved highlighting nanoplatforms prevent loss intracellular environment. Moreover, review advances MNP-based embrace concept multimodal therapy, aims combine with chemotherapy, radiotherapy, immunotherapy, photodynamic or phototherapy. Next, better control temperature at tumor, focus studies optimized maintain gold-standard performance also tackling aim quantitatively assess amount tumor site regulate conditions. To conclude, future perspectives guidance how advance therapy will provided.
Язык: Английский
Процитировано
324
Nano Select, Год журнала: 2021, Номер 2(6), С. 1146 - 1186
Опубликована: Янв. 21, 2021
Abstract Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions biological media largely rely on their crystal structures, sizes, and shapes, detailed studies synthesis mechanism medicinal aspects are crucial. Despite many review reports that have already been published MNPs, they mainly focused either perspective or characterization along with functionalization mechanisms as individual entities. For this reason, uncovers comprehensive insight into the ongoing improvement of fabrication processes, surface MNPs together. Besides, various magnetic nanocomposite (MNCs) smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, bio‐separation, some emerging imaging techniques using discussed. A analysis toxicity, challenges, progress clinical trials is sketched out to open numerous entryways advanced research applications.
Язык: Английский
Процитировано
212
Biomaterials Science, Год журнала: 2022, Номер 10(9), С. 2103 - 2121
Опубликована: Янв. 1, 2022
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted attention in the biomedical field thanks to their ability prompt hyperthermia response an alternated magnetic field. Hyperthermia is well known for inducing cell death, particular tumour cells, which seem a higher sensitivity temperature increases. For this reason, has been recommended as therapeutic tool against cancer. Despite potentialities of approach, little still about effects provoked by at molecular level, and death mechanisms that are activated. Nevertheless, in-depth knowledge aspect would allow improvement outcomes favour clinical translation. Moreover, last few decades, lot effort put into finding effective delivery strategy could improve SPION biodistribution localisation action site. The aim review provide general outline hyperthermia, focusing on interactions with fields, new strategies efficiently deliver them target site, recent vitro vivo studies proposing possible pathways activated treatment. We will also cover current status, discuss contributions omics understanding between biological environment.
Язык: Английский
Процитировано
117
Materials Advances, Год журнала: 2022, Номер 3(20), С. 7425 - 7444
Опубликована: Янв. 1, 2022
Magnetic nanoparticles (MNPs) show tremendous possibilities in the field of biomedicine, especially as therapeutic agents for use over a prolonged duration.
Язык: Английский
Процитировано
70
Nanomaterials, Год журнала: 2020, Номер 10(8), С. 1548 - 1548
Опубликована: Авг. 7, 2020
The photothermal use of iron oxide magnetic nanoparticles (NPs) is becoming more and popular documented. Herein, we compared the (PT) therapy potential versus hyperthermia (MHT) modality nanospheres, largely used in biomedical field multicore nanoflowers known among best nanoheaters. NPs were imaged using transmission electron microscopy their optical properties characterized by UV-Vis-NIR-I-II before oxidation (magnetite) after to maghemite. efficiency all MHT PT preferred second near-infrared (NIR-II) biological window was carried out water cancer cells. We show that, water, magnetite are most efficient nanoheaters for both modalities. Moreover, appears much than at low NP dose, whatever NP. In cellular environment, PT, totally conserved, with as performers MHT, which lost. Finally, cell uptake significantly increased nanospheres. antitumor investigated same dose delivered cells reasonable laser power density (0.3 W/cm2), showed almost total death nanoflowers.
Язык: Английский
Процитировано
81
Frontiers in Molecular Biosciences, Год журнала: 2021, Номер 7
Опубликована: Янв. 11, 2021
Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such chemotherapy, radiotherapy, surgical intervention. Notably, the advantage of is mainly attributable their accumulation targeting ability toward cells, multiple drug-carrying abilities, combined therapies, approaches. To date, numerous nanoparticle formulations developed for therapy among them, metallic reportedly demonstrate promising therapeutic diagnostic efficiencies owing dense surface functionalization ability, uniform size distribution, shape-dependent optical responses, easy cost-effective synthesis procedure, anti-cancer effects. Metallic can remodel tumor microenvironment by changing unfavorable conditions into therapeutically accessible ones with help different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, reactive oxygen species. The combination both external internal stimuli be used trigger on-demand release molecules, augmenting efficacies photothermal therapy, photodynamic hyperthermia, sonodynamic chemodynamic immunotherapy. In this review, we summarized role well combinational effects enhanced therapy.
Язык: Английский
Процитировано
66
Nanoscale, Год журнала: 2021, Номер 13(39), С. 16405 - 16426
Опубликована: Янв. 1, 2021
The present review article provides the insight of an overall survey on recent advancements manganese nanomaterials for biomedical nanotechnology and other fields.
Язык: Английский
Процитировано
62
Small, Год журнала: 2022, Номер 18(13)
Опубликована: Фев. 8, 2022
Abstract Extracellular vesicles (e.g., exosomes) carrying various biomolecules proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, heterogeneity in surfaces sizes, the high complexity of cargo biomolecules, inefficient uptake by recipient cells remain critical barriers theranostic To address these issues, multifunctional nanomaterials, such magnetic with tunable physical, chemical, biological properties, may play crucial roles next‐generation extracellular (EV)‐based disease diagnosis, drug delivery, tissue engineering, regenerative medicine. As such, one aims to provide cutting‐edge knowledge pertaining nanomaterials‐facilitated isolation, detection, delivery associated biomolecules. By engaging fields it is envisioned that properties can be effectively combined optimal outcomes
Язык: Английский
Процитировано
57
Advanced Functional Materials, Год журнала: 2023, Номер 33(13)
Опубликована: Янв. 17, 2023
Abstract Developing radiosensitizers based on the characteristics of tumor microenvironment can improve effectiveness and overcome bottleneck cervical cancer radiotherapy. Herein, an in situ synthesis strategy is demonstrated by using a highly bioactive zeolitic imidazolate framework to cap Mn 3 O 4 folic acid as targeting molecules (FA‐Mn @ZIF‐8) achieve enhanced radiosensitization against cancer. As expected, ZIF‐8 surface responds more effectively X‐rays. Meanwhile, facilitating presence oxygen vacancies valence transition manganese , increase catalytic capacity for hydrogen peroxide (H 2 ) glutathione well produce singlet under X‐ray, alleviate hypoxia within microenvironment, reactive species production. Moreover, FA‐Mn @ZIF‐8 shows excellent radiotherapy‐sensitizing properties vitro vivo promoting DNA damage apoptosis. Collectively, this study suggests that designing construction X‐ray responsive nanoradiosensitizers could be good way future clinical radiotherapy malignant
Язык: Английский
Процитировано
34