Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

Biomedicines, Год журнала: 2023, Номер 11(2), С. 292 - 292

Опубликована: Янв. 20, 2023

The eye is a metabolically active structure, constantly exposed to solar radiations making its structure vulnerable the high burden of reactive oxygen species (ROS), presenting many molecular interactions. biomolecular cascade modification caused especially in diseases ocular surface, cornea, conjunctiva, uvea, and lens. In fact, injury anterior segment takes origin from perturbation pro-oxidant/antioxidant balance leads increased oxidative damage, when first line antioxidant defence weakens with age. Furthermore, stress related mitochondrial dysfunction, DNA lipid peroxidation, protein modification, apoptosis, inflammation, which are involved disease progression such as dry eye, keratoconus, uveitis, cataract. different pathologies interconnected through various mechanisms diagnostics more relevant early stages. end point pathway release biomarkers offering potential predictive pathology. this review, we have analysed inflammatory processes front provide better understanding pathomechanism, importance for diagnosis diseases, recent treatment diseases.

Язык: Английский

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Self-reported symptoms of mask-associated dry eye: A survey study of 3,605 people

Contact Lens and Anterior Eye, Год журнала: 2021, Номер 45(2), С. 101408 - 101408

Опубликована: Янв. 20, 2021

Язык: Английский

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<p>A Review of Contact Lens Dropout</p>

Clinical Optometry, Год журнала: 2020, Номер Volume 12, С. 85 - 94

Опубликована: Июнь 1, 2020

Purpose: Contact lens (CL) dropout is likely a major factor contributing to the near stagnant growth in CL market. The purpose of this review summarize current state knowledge related frequency and factors associated with it. Methods: PubMed.gov was searched on or before March 22, 2020, terms "contact lens" "dropout" "cessation" "disruption" "discomfort". Pertinent articles were collected. references from these likewise identify additional relevant articles. Only manuscripts written English included. No study design date exclusions imposed review. Results: This literature found that frequent across developed countries, ranged between 12.0% 27.4% (pooled mean = 21.7%). top cited reason for established wearers discomfort, while vision neophyte wearers. If given chance, dropouts are often able successfully resume wear up 74% time. While mixed regard promoting dropout, meibomian gland dysfunction appears promote dropout. Conclusion: frequently encountered condition may be curtailed by early detection, patient education, alterative options, treatment underlying ocular surface diseases such as dysfunction. Keywords: contact cessation, dry eye,

Язык: Английский

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Characteristics and Risk Factors Associated With Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application

JAMA Ophthalmology, Год журнала: 2019, Номер 138(1), С. 58 - 58

Опубликована: Ноя. 27, 2019

The incidence of dry eye disease has increased; the potential for crowdsource data to help identify undiagnosed in symptomatic individuals remains unknown.To assess characteristics and risk factors associated with diagnosed using smartphone app DryEyeRhythm.A cross-sectional study crowdsourced was conducted including Japan who downloaded DryEyeRhythm completed entire questionnaire; duplicate users were excluded. released on November 2, 2016; from 2016, January 12, 2018.DryEyeRhythm collected demographics, medical history, lifestyle, subjective symptoms, disease-specific Ocular Surface Disease Index (100-point scale; scores 0-12 indicate normal, healthy eyes; 13-22, mild eye; 23-32, moderate 33-100, severe symptoms), Zung Self-Rating Depression Scale (total 20 items, total score ranging 20-80, ≥40 highly suggestive depression).Multivariate-adjusted logistic regression analysis used eye.A 21 394 records identified our database; 4454 users, included 899 participants (27.3%) 2395 (72.7%) eye, all questionnaires their analyzed. A 2972 (66.7%) women; mean (SD) age 27.9 (12.6) years. vs no younger (odds ratio [OR], 0.99; 95% CI, 0.987-0.999, P = .02), female sex (OR, 1.99; 1.61-2.46; < .001), pollinosis (termed hay fever questionnaire) 1.35; 1.18-1.55; depression 1.78; 1.18-2.69; .006), mental illnesses other than or schizophrenia 1.87; 1.24-2.82; .003), current contact lens use 1.27; 1.09-1.48; .002), extended screen exposure 1.55; 1.25-1.91; smoking 1.65; 1.37-1.98; .001). 0.96; 0.95-0.97; male 0.55; 0.42-0.72; as well absence collagen 0.23; 0.09-0.60; 0.50; 0.36-0.69; ophthalmic surgery cataract laser-assisted situ keratomileusis 0.41; 0.27-0.64; 0.64; 0.54-0.77; .001) past 0.45; 0.34-0.58; use.This study's findings suggest that research factors. These could play a role earlier prevention more effective interventions disease.

Язык: Английский

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Tear Metabolomics in Dry Eye Disease: A Review

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(15), С. 3755 - 3755

Опубликована: Авг. 1, 2019

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of precorneal tear film. It considered one most common ocular conditions leading patients to seek care. The current method for diagnostic evaluations and follow-up examinations DED combination clinical signs symptoms determined tests questionnaires, respectively. application powerful omics technologies has opened new avenues toward analysis subjects health disease. Metabolomics emerging complementary research discipline all modern comprehensive biological systems. identification distinct metabolites integrated metabolic profiles potentially inform clinicians at an early stage during monitoring progression, enhancing diagnosis, prognosis, choice therapy. In ophthalmology, metabolomics gained considerable attention over past decade but very limited such studies have been reported on DED. This paper aims review

Язык: Английский

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Prevalence of Dry Eye Symptoms and Associated Risk Factors among University Students in Poland

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(2), С. 1313 - 1313

Опубликована: Янв. 11, 2023

Aim: The aim of the study was to demonstrate prevalence and risk factors dry eye symptoms (DES) among university students in Poland. Material methods: A cross-sectional survey conducted 312 Polish students. questionnaire consisted Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ-5) questions regarding medical history factors. Results: According OSDI, more than half respondents (57.1%) have ocular surface disease. Time spent using electronic devices is correlated with scores gathered both OSDI DEQ-5 (p < 0.001). There a statistically significant dependence between psychotropics = 0.002), glucocorticosteroids usage 0.026), presence depression 0.001), diabetes 0.01) or allergy 0.008) proved questionnaires. Respondents refractive errors those living metropolitan areas higher symptom intensity(p 0.022). Stress felt by associated DES risk. No correlation smoking habits observed. SARS-CoV-2 infection severity 0.036). Conclusion: Pathogenesis multifactorial its depends on several factors, genetic environmental. Its young population underestimated. Determining will enable implementation appropriate prophylaxis early diagnosis.

Язык: Английский

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Intense pulsed light treatment in meibomian gland dysfunction: A concise review

The Ocular Surface, Год журнала: 2020, Номер 18(4), С. 583 - 594

Опубликована: Июль 4, 2020

To review the published literature related to application of intense pulsed light (IPL) for treating meibomian gland dysfunction (MGD). The search included PubMed database and used keywords "Intense Pulsed Light Meibomian Gland Dysfunction". IPL is a new instrumental treatment modality MGD. This was originally developed use in dermatology later adopted ophthalmology therapy MGD can improve tear film stability, functionality, as well subjective feeling ocular dryness. However, reviewed literature, there great variability patient selection, evaluation criteria, protocols durations. Numerous studies report that effective safe procedure. There potential further improvements procedure, large comparative employing different modalities are lacking.

Язык: Английский

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BCLA CLEAR - Evidence-based contact lens practice

Contact Lens and Anterior Eye, Год журнала: 2021, Номер 44(2), С. 368 - 397

Опубликована: Март 25, 2021

Язык: Английский

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The Role of Oxidative Stress in the Aging Eye

Life, Год журнала: 2023, Номер 13(3), С. 837 - 837

Опубликована: Март 20, 2023

Given the expanding elderly population in United States and world, it is important to understand processes underlying both natural pathological age-related changes eye. Both anterior posterior segment of eye undergo biological, chemical, physical properties driven by oxidative stress. With advancing age, include dermatochalasis, blepharoptosis, thickening sclera, loss corneal endothelial cells, stiffening lens. Changes lowered viscoelasticity vitreous body, photoreceptor cell loss, drusen deposition at macula fovea. Age-related ocular pathologies including glaucoma, cataracts, macular degeneration are largely mediated The prevalence these diseases expected increase coming years, highlighting need develop new therapies that address stress slow progression pathologies.

Язык: Английский

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Unveiling senescence-associated ocular pathogenesis via lacrimal gland organoid magnetic bioassembly platform and HMGB1-Box A gene therapy

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 18, 2024

Язык: Английский

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