Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 15471 - 15483

Published: Aug. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Language: Английский

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H₂S‐Activated Ion‐Interference Therapy: A Novel Tumor Targeted Therapy Based on Copper‐Overload‐Mediated Cuproptosis and Pyroptosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(38)

Published: June 6, 2023

Abstract Copper overload is a novel way to achieve copper‐ion‐interference therapy by disrupting copper homeostasis and treating diseases through multiple cell death pathways. However, it difficult reach since excess intracellular ions will be pumped out. Herein, achieved both raising cellular uptake reducing the efflux of using hydrogen sulfide (H 2 S)‐responsive hydroxyphosphate nanoparticles (Cu (PO 4 )(OH) NPs). After immersion in an H S‐enriched colon cancer microenvironment, Cu NPs can transform into with reduced size for higher entering, resulting improved Fenton activity as well ion dissociation. Reactive oxygen species generated reaction not only activate inflammasomes Caspase‐1 proteins, cause cleavage gasdermin D induce pyroptosis, but also affect mitochondrial function down‐regulate exporter ATP7A further reduce excretion. The combination endocytosis lower exportation leads maximized overload. Together efficient release, tricarboxylic acid cycle disrupted iron‐sulfur cluster proteins are downregulated, ultimately triggering cuproptosis. As pyroptosis cuproptosis ways death, this study provides realize effective tumor‐targeted based on S‐activated simple NPs.

Language: Английский

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Recent progress of MOF-functionalized nanocomposites: From structure to properties

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 323, P. 103050 - 103050

Published: Nov. 10, 2023

Language: Английский

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Self‐Reinforced MOF‐Based Nanogel Alleviates Osteoarthritis by Long‐Acting Drug Release

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Abstract Intra‐articular injection of drugs is an effective strategy for osteoarthritis (OA) treatment. However, the complex microenvironment and limited joint space result in rapid clearance drugs. Herein, a nanogel‐based proposed prolonged drug delivery remodeling. Nanogel constructed through functionalization hyaluronic acid (HA) by amide reaction on surface Kartogenin (KGN)‐loaded zeolitic imidazolate framework‐8 (denoted as KZIF@HA). Leveraging inherent hydrophilicity HA, KZIF@HA spontaneously forms nanogels, ensuring extended release OA microenvironment. exhibits sustained over one month, with low leakage risk from cavity compared to KZIF, enhanced cartilage penetration, reparative effects chondrocytes. Notably, KGN released serves promote extracellular matrix (ECM) secretion hyaline regeneration. Zn 2+ reverses progression promoting M2 macrophage polarization establish anti‐inflammatory Ultimately, facilitates regeneration alleviation within three months. Transcriptome sequencing validates that stimulates macrophages secretes IL‐10 inhibit JNK ERK pathways, chondrocytes recovery enhancing ECM This pioneering nanogel system offers new therapeutic opportunities release, presenting significant stride treatment strategies.

Language: Английский

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Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca²⁺/Cu²⁺ Dual-Ions Nano Trap for Breast Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6975 - 6989

Published: Feb. 20, 2024

Regarded as one of the hallmarks tumorigenesis and tumor progression, evasion apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid apoptosis by synchronously inducing paraptosis together with was successfully designed fabricated breast treatment. brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were via gas diffusion method. Further on, Cu2+-tannic acid metal phenolic network embedded onto NPs surface self-assembling, followed mDSPE-PEG/lipid capping form DSF-loaded dual-ions trap". The as-prepared nanotrap undergo acid-triggered biodegradation upon being endocytosed cells within lysosome Ca2+, Cu2+, DSF releasing simultaneously. released Ca2+ could cause mitochondrial overload lead hydrogen peroxide (H2O2) overexpression. Meanwhile, Ca2+/reactive oxygen species-associated dysfunction death. Most importantly, be further induced strengthened toxic dithiocarbamate (DTC)–copper complexes formed Cu2+ combined DTC, metabolic products DSF. Additionally, will reduced intracellular glutathione generate Cu+, which can catalyze H2O2 produce hydroxyl radical Cu+-mediated Fenton-like reaction apoptosis. Both in vitro cellular assays vivo antitumor evaluations confirmed therapeutic efficiency dual ion nano trap. This study broaden cognition scope dual-ion-mediated multifunctional nanoplatform.

Language: Английский

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Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 21911 - 21924

Published: Aug. 5, 2024

Mass transfer of bulky molecules,

Language: Английский

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Biomimetic ZIF-8 Nanoparticles: A Novel Approach for Biomimetic Drug Delivery Systems

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5523 - 5544

Published: June 1, 2024

Metal-organic frameworks (MOFs) are porous materials resulting from the coordination of metal clusters or ions with organic ligands, merging macromolecular and chemistry features. Among these, zeolitic imidazolate framework-8 (ZIF-8) stands out as a widely utilized MOF known for its robust stability in aqueous environments owing to interaction between constituent zinc (Zn

Language: Английский

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Nanomaterials via ZIF-8: Preparations, catalytic and drug delivery applications

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160663 - 160663

Published: Feb. 1, 2025

Language: Английский

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Biometallic ions and derivatives: a new direction for cancer immunotherapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

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Graphene-Based Nanomaterials for Photothermal Therapy in Cancer Treatment

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2286 - 2286

Published: Sept. 6, 2023

Graphene-based nanomaterials (GBNMs), specifically graphene oxide (GO) and reduced (rGO), have shown great potential in cancer therapy owing to their physicochemical properties. As GO rGO strongly absorb light the near-infrared (NIR) region, they are useful photothermal (PTT) for treatment. However, despite structural similarities of rGO, exhibit different influences on anticancer treatment due capacities. In this review, various characterization techniques used compare features first outlined. Then, a comprehensive summary discussion applicability GBNMs context PTT diverse types presented. This includes integration with secondary therapeutic strategies, particular focus capacity achieved through irradiation parameters modifications implemented. Furthermore, dedicated section is devoted studies hybrid magnetic-GBNMs. Finally, challenges prospects associated utilization GBNM PTT, primary emphasis clinical translation, addressed.

Language: Английский

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