Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: July 11, 2024
Cancer,
being
one
of
the
deadliest
diseases,
poses
significant
challenges
despite
existence
traditional
treatment
approaches.
This
has
led
to
a
growing
demand
for
innovative
pharmaceutical
agents
that
specifically
target
cancer
cells
effective
treatment.
In
recent
years,
use
metal
nanoparticles
(NPs)
as
promising
alternative
conventional
therapies
gained
prominence
in
research.
Metal
NPs
exhibit
unique
properties
hold
tremendous
potential
various
applications
Studies
have
demonstrated
certain
metals
possess
inherent
or
acquired
anticancer
capabilities
through
their
surfaces.
These
make
an
attractive
focus
therapeutic
development.
this
review,
we
will
investigate
applicability
several
distinct
classes
tumor
targeting
may
include
gold,
silver,
iron
oxide,
and
other
with
can
be
exploited
purposes.
Additionally,
provide
comprehensive
summary
risk
factors
associated
application
NPs.
Understanding
addressing
these
crucial
successful
clinical
translation
mitigate
any
failures
NP-based
therapies.
By
exploring
identifying
factors,
review
aims
contribute
advancement
strategies.
The
anticipated
outcome
is
valuable
insights
pave
way
targeted
utilizing
patients.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(3), P. 622 - 622
Published: Jan. 26, 2022
Several
drug-delivery
systems
have
been
reported
on
and
often
successfully
applied
in
cancer
therapy.
Cell-targeted
delivery
can
reduce
the
overall
toxicity
of
cytotoxic
drugs
increase
their
effectiveness
selectivity.
Besides
traditional
liposomal
micellar
formulations,
various
nanocarrier
recently
become
focus
developmental
interest.
This
review
discusses
preparation
targeting
techniques
as
well
properties
several
liposome-,
micelle-,
solid-lipid
nanoparticle-,
dendrimer-,
gold-,
magnetic-nanoparticle-based
systems.
Approaches
for
targeted
drug
release
under
a
range
stimuli
are
also
discussed.
Materials Advances,
Journal Year:
2022,
Volume and Issue:
3(20), P. 7425 - 7444
Published: Jan. 1, 2022
Magnetic
nanoparticles
(MNPs)
show
tremendous
possibilities
in
the
field
of
biomedicine,
especially
as
therapeutic
agents
for
use
over
a
prolonged
duration.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(22)
Published: March 25, 2023
Reactive
oxygen
species
(ROS)-mediated
tumor
catalytic
therapy
is
typically
hindered
by
gap
junction
proteins
that
form
cell-to-cell
channels
to
remove
cytotoxic
ROS,
thereby
protecting
cells
from
oxidative
damage.
In
this
work,
a
multifunctional
nanozyme,
FePGOGA,
designed
and
prepared
Fe(III)-mediated
polymerization
(FeP),
followed
glucose
oxidase
(GOx)
GAP19
peptides
co-loading
through
electrostatic
π-π
interactions.
The
FePGOGA
nanozyme
exhibits
excellent
cascade
peroxidase-
glutathione-oxidase-like
activities
efficiently
catalyze
hydrogen
peroxide
conversion
hydroxyl
radicals
convert
reduced
glutathione
oxidized
disulfide.
loaded
GOx
starves
the
tumors
aggravates
stress
decomposition,
while
block
hemichannels
inducing
degradation
of
Cx43,
thus
increasing
accumulation
intracellular
decreasing
transport
glucose.
Furthermore,
ROS
reacts
with
primary
amines
heat
shock
destroy
their
structure
function,
enabling
photothermal
at
widely
sought-after
mild
temperature
(mildPTT,
≤45
°C).
vivo
experiments
demonstrate
significant
antitumor
effectof
on
cal27
xenograft
under
near-infrared
light
irradiation.
This
study
demonstrates
successful
ablation
overcome
resistance
ROS-mediated
therapy,
providing
regulator
suppress
self-preservation
during
starvation,
mildPTT.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100633 - 100633
Published: April 12, 2023
With
the
development
of
nanotechnology,
nanoparticles
have
emerged
as
a
delivery
carrier
for
tumor
drug
therapy,
which
can
improve
therapeutic
effect
by
increasing
stability
and
solubility
prolonging
half-life
drugs.
However,
are
foreign
substances
humans,
easily
cleared
immune
system,
less
targeted
to
tumors,
may
even
be
toxic
body.
As
natural
biological
material,
cell
membranes
unique
properties,
such
good
biocompatibility,
strong
targeting
ability,
ability
evade
surveillance,
high
drug-carrying
capacity.
In
this
article,
we
review
membrane-coated
(CMNPs)
their
applications
therapy.
First,
briefly
describe
CMNP
characteristics
applications.
Second,
present
advantages
different
well
nanoparticles,
provide
brief
description
process
CMNPs,
discuss
current
status
application
summarize
shortcomings
use
in
cancer
propose
future
research
directions.
This
summarizes
progress
on
CMNPs
therapy
recent
years
assesses
remaining
problems,
providing
scholars
with
new
ideas
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 868 - 868
Published: March 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
