Materials Science and Engineering C, Journal Year: 2019, Volume and Issue: 97, P. 978 - 993
Published: Jan. 2, 2019
Language: Английский
Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108
Published: Sept. 27, 2018
The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.
Language: Английский
Citations
2456
Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985
Published: April 11, 2019
Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.
Language: Английский
Citations
2022
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Language: Английский
Citations
588
Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 2891 - 2912
Published: Jan. 1, 2019
The emergence of novel two-dimensional (2D) monoelemental materials (Xenes) has shown remarkable potential for their applications in different fields technology, as well addressing new discoveries fundamental science. Xenes (e.g., borophene, silicene, germanene, stanene, phosphorene, arsenene, antimonene, bismuthene, and tellurene) are particular interest because they the most chemically tractable synthetic exploration. Owing to excellent physical, chemical, electronic optical properties, have been regarded promising agents biosensors, bioimaging, therapeutic delivery, theranostics, several other bio-applications. In this tutorial review, we summarize general properties including classification according bulk properties. modification methods also presented. Furthermore, representative Xene nanoplatforms various biomedical highlighted. Finally, research progress, challenges, perspectives future development biomedicines discussed.
Language: Английский
Citations
555
Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(13)
Published: Feb. 4, 2019
Abstract Black phosphorus (BP) has increasingly attracted scientific attention since its first applications in biomedicine due to unique properties and excellent biocompatibility. In particular, layer‐dependent bandgap, moderate carrier mobility, large surface‐area‐to‐volume ratio, biodegradability, intrinsic photoacoustic properties, biocompatibility make it an ideal candidate for use photothermal therapy, photodynamic drug delivery, 3D printing, bioimaging, biosensing, theranostics, which are reviewed here. addition, the article discusses strategies overcome challenges related surface instability chemical degradation, a major obstacle application. This review not only provides comprehensive summary on BP preparation biomedical but also summarizes recent research future possibilities.
Language: Английский
Citations
527
Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742
Published: Jan. 1, 2021
Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.
Language: Английский
Citations
364
Advanced Optical Materials, Journal Year: 2019, Volume and Issue: 8(1)
Published: Sept. 24, 2019
Abstract Self‐powered photodetectors are considered as a new type of enabling self‐powered photodetection without external power. The excellent photoresponsivity, fast photoresponse rate, low dark current, and large light on/off ratio these have attracted wide interest among scholars. 2D materials widely used in due to their optical electrical properties, unique structures, capabilities exhibit performance. According the self‐driving mechanism material‐based photodetectors, they divided into three categories: p–n junction Schottky photoelectrochemical photodetectors. From perspectives, research progress is summarized detail here. Research reports indicate that behavior, good characteristics, wideband spectral response ranges. performance facilitates potential applications field optoelectronic devices. In particular, great novel emerging self‐driven Finally, directions for further development anticipated.
Language: Английский
Citations
337
Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574
Published: Feb. 28, 2022
Language: Английский
Citations
316
Nano-Micro Letters, Journal Year: 2019, Volume and Issue: 11(1)
Published: Nov. 16, 2019
Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell properties, and active area ongoing research readily applicable nanoscale biomedicine. Nanoparticles (NPs) coated with membranes offer opportunity unite natural properties those artificial inner core material. The NPs not only increase their biocompatibility but also achieve effective extended circulation in vivo, allowing for execution targeted functions. Although membrane-coated clear advantages, much work remains before they can be applied clinical practice. In this review, we first provide a comprehensive overview theory technology, followed by summary existing preparation characterization techniques. Next, focus on functions applications various types. addition, collate model drugs used review patent related from past 10 years. Finally, survey future challenges trends pertaining effort development technology.
Language: Английский
Citations
309
Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)
Published: June 8, 2020
The use of photothermal agents (PTAs) in cancer therapy (PTT) has shown promising results clinical studies. rapid degradation PTAs may address safety concerns but usually limits the stability required for efficacious treatment. Conversely, with high degrade slowly. solutions that balance between and are rare. Here, we report inherent Cu2+-capturing ability black phosphorus (BP) can accelerate BP, while also enhancing stability. incorporation Cu2+ into BP@Cu nanostructures further enables chemodynamic (CDT)-enhanced PTT. Moreover, by employing 64Cu2+, positron emission tomography (PET) imaging be achieved vivo real-time quantitative tracking. Therefore, our study not only introduces an "ideal" PTA bypasses limitations PTAs, provides proof-of-concept application BP-based materials PET-guided, CDT-enhanced combination therapy.
Language: Английский
Citations
296