Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(35), P. 14789 - 14804

Published: Aug. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Language: Английский

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Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(13), P. 5359 - 5368

Published: March 13, 2019

Planar donor and acceptor (D–A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order restrict intramolecular motions aggregates (nanoparticles). However, other channels of extra nonradiative decay may blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion aggregates. Molecular rotors bulky alkyl chains grafted central D–A core lower intermolecular interaction. The enhanced favors formation a dark twisted charge transfer state, whose enhances properties. Result shows that small-molecule NIRb14 with long branched at second carbon exhibits properties compared NIRb6, short chains, much higher than NIR6, linear commercial gold nanorods. Both vitro vivo experiments demonstrate nanoparticles can used as nanoagents photoacoustic imaging-guided therapy. Moreover, reversal poly(β-amino ester) makes specifically accumulate tumor sites. This study thus provides excited approach toward phototheranostic agents.

Language: Английский

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Optical nano-agents in the second near-infrared window for biomedical applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 22 - 37

Published: Nov. 16, 2018

This review summarizes the recent advances of optical nano-agents for various biomedical applications in NIR-II window.

Language: Английский

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Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery

Nano Letters, Journal Year: 2018, Volume and Issue: 19(1), P. 318 - 330

Published: Dec. 17, 2018

Afterglow imaging through the collection of persistent luminescence after stopping light excitation holds enormous promise for advanced biomedical uses. However, efficient near-infrared (NIR)-emitting afterglow luminescent materials and probes (particularly organic polymeric ones) are still very limited, their in-depth applications such as precise image-guided cancer surgery rarely reported. Here, we design synthesize a NIR nanoparticle with aggregation-induced emission (AIE) characteristics (named AGL AIE dots). It is demonstrated that dots emit rather-high persisting over 10 days single series processes occurring in dots, including singlet oxygen production by luminogens (AIEgens), Schaap's dioxetane formation, chemiexcitation decomposition, energy transfer to NIR-emitting AIEgens. The animal studies reveal have innate property fast signal quenching normal tissues, liver, spleen, kidney. After intravenous injection into peritoneal carcinomatosis bearing mice, tumor-to-liver ratio nearly 100-fold larger than fluorescence imaging. ultrahigh ratio, together low background noise, enables give excellent performance surgery.

Language: Английский

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Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(29), P. 11717 - 11731

Published: March 5, 2020

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence biological tissue between 650-900 nm, conventional optical often has poor signal-to-background ratio shallow penetration depth, which limits its ability deep-tissue vivo imaging. Second near-infrared fluorescence, chemiluminescence, photoacoustic modalities mitigate these issues by their respective advantages of minimized scattering, eliminated external excitation, ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the change second or signals response biomarker have been developed. This Minireview summarizes design strategies, sensing mechanisms, applications AMPs. The potential challenges perspectives AMPs are also discussed.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 20, 2020

Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion for photoacoustic (PA) imaging-guided second near-infrared ferrotherapy. HSN comprises an amphiphilic polymer as converter, PA emitter and iron-chelating catalyst. Upon photoirradiation, generates heat not only induce cytotoxicity but also enhance reaction. The increased ·OH generation promotes both ferroptosis apoptosis, oxidizes (42 nm) transforms it into tiny segments (1.7 elevated intratumoral permeability. non-invasive seamless synergism leads amplified effects including deep ablation depth (9 mm), reduced expression of metastasis-related proteins inhibition metastasis from primary distant organs. Thereby, our study provides generalized strategy compensate phototherapeutics complete regression.

Language: Английский

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