Engineering precision nanoparticles for drug delivery

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 20(2), P. 101 - 124

Published: Dec. 4, 2020

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Targeted drug delivery strategies for precision medicines

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(4), P. 351 - 370

Published: Feb. 2, 2021

Language: Английский

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Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(52)

Published: Nov. 7, 2019

Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient to achieve satisfactory immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, specific ability is reported effectively inducing focused mitochondrial oxidative stress of cells, which serve as much superior inducer popularly used ones, including chlorin e6 (Ce6), pheophorbide A, oxaliplatin. Furthermore, more effective in vivo immunogenicity TPE-DPA-TCyP than Ce6 also demonstrated using prophylactic tumor vaccination model. The underlying mechanism effectiveness robustness antitumor immunity immune-memory effect verified immune analyses. This study thus reveals that highly strategy evoke abundant large-scale ICD.

Language: Английский

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A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Nov. 4, 2019

The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, it is hard to cure completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2 MoS4 (CMS) loaded with glucose oxidase (GOx) constructed for synergetic therapy by chemo-dynamic (CDT)/starvation therapy/phototherapy/immunotherapy. CMS harboring multivalent elements (Cu1+/2+ , Mo4+/6+ ) exhibit Fenton-like, glutathione (GSH) peroxidase-like catalase-like activity. Once internalized into the tumor, could generate ·OH CDT Fenton-like reaction deplete overexpressed GSH in TME alleviate antioxidant capability of tumors. Moreover, under hypoxia TME, react endogenous H2 O2 activating catalyzed oxidation GOx starvation accompanied regeneration . regenerated can devote realizing GOx-catalysis-enhanced CDT. Meanwhile, 1064 nm laser irradiation shows remarkable tumor-killing ability phototherapy due its excellent photothermal conversion efficiency (η = 63.3%) cytotoxic superoxide anion (·O2- generation performance. More importantly, PEGylated CMS@GOx-based synergistic combined checkpoint blockade elicit robust immune responses both effectively ablating primary tumors inhibiting metastasis.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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Supramolecular Photothermal Nanomedicine Mediated Distant Tumor Inhibition via PD-1 and TIM-3 Blockage

Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 8

Published: Feb. 14, 2020

Supramolecular nanoparticles for photothermal therapy (PTT) have shown promising therapeutic efficacy in the primary tumor and great potential turning whole-body immune microenvironment from "cold" to "hot," which allows simultaneous treatment of metastatic site. In this work, we develop a liposome-based PTT nanoparticle through self-assembly FDA-approved intravenous injectable lipids agent, indocyanine green (ICG). The obtained ICG-liposome shows long-term storage stability, high ICG encapsulation efficiency (>95%), enhanced near-infrared (NIR) light-triggered reaction both

Language: Английский

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CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 30, 2023

In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This consists of genetically engineered immune cells expressing surface receptor, called CAR, that specifically targets antigens expressed on tumor cells. hematological malignancies like leukemias, myeloma, and non-Hodgkin B-cell lymphomas, adoptive CAR-T shown efficacy in treating chemotherapy refractory patients. However, value this remains inconclusive context solid tumors is restrained by several obstacles including limited trafficking infiltration, presence an immunosuppressive microenvironment, well adverse events associated with such therapy. Recently, CAR-Natural Killer (CAR-NK) CAR-macrophages (CAR-M) were introduced complement/alternative for tumors. CAR-NK could be favorable substitute since they do not require HLA compatibility have toxicity. Additionally, might generated large scale from sources which would suggest them off-the-shelf product. CAR-M immunotherapy its capabilities phagocytosis, tumor-antigen presentation, broad currently being investigated. Here, we discuss emerging role CAR-T, CAR-NK, We also highlight advantages drawbacks compared Finally, prospective solutions potential combination therapies enhance CAR-cells immunotherapy.

Language: Английский

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Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(13), P. 5365 - 5451

Published: Jan. 1, 2022

The present review details a chronological description of the events that took place during development mesoporous materials, their different synthetic routes and use as drug delivery systems. outstanding textural properties these materials quickly inspired translation to nanoscale dimension leading silica nanoparticles (MSNs). aspects introducing pharmaceutical agents into pores nanocarriers, together with possible biodistribution clearance routes, would be described here. smart nanocarriers are able release high local concentration therapeutic cargo on-demand after application certain stimuli reviewed here, ability deliver precise locations in body. huge progress design MSNs for biomedical applications, including potential treatment diseases, last 20 years will collated required work still needs done achieve clinical materials. This was conceived stand out from past reports since it aims tell story systems by some makers, who could considered among pioneers this area.

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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