Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Piezoelectric nanogenerators for personalized healthcare

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3380 - 3435

Published: Jan. 1, 2022

Piezoelectric nanogenerators are becoming a compelling bioelectronics platform technology for human-associated energy harvesting, self-powered sensing, and therapeutics, which will largely contribute to the medical field in era of Internet things.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant Staphylococcus aureus-Infected Osteomyelitis

ACS Nano, Journal Year: 2021, Volume and Issue: 15(6), P. 10628 - 10639

Published: June 4, 2021

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited tissue, situ rapid treatments for osteomyelitis remain significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst consists of Au nanorod (NRs)-actuated single-atom-doped porphyrin metal–organic framework (HNTM-Pt@Au) red cell membrane (RBC), which efficiently treat methicillin-resistant Staphylococcus aureus (MRSA)-infected under US. Besides outstanding performance field photocatalysis, find single atoms (such Pt, Au, Cu) also improve sonocatalytic ability sonosensitizer. Due to strong electron-trapping oxygen adsorption capacity, Pt atom endows RBC-HNTM-Pt@Au with excellent activity. It shows antibacterial efficiency 99.9% toward MRSA 15 min US irradiation. Meanwhile, be propelled directionally thus dynamically neutralize secreted toxins. The MRSA-infected rat tibia was successfully treated, negligible loss, reduced inflammation response, great biocompatibility. This work presents efficient sonodynamic therapy treatment deep tissue infections via multifunctional catalyst.

Language: Английский

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Catalytically Active CoFe₂O₄ Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 11953 - 11969

Published: June 18, 2021

A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer development through complex cellular signaling networks, it is thus challenging to completely eradicate tumors via monotherapy. Here, PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities, serving as bioreactors responsive TME cues, were synthesized typical solvothermal method for augmented sonodynamic therapy (SDT) chemodynamic (CDT) elicitation of robust immune response. The CFP occupying multivalent elements (Co2+/3+, Fe2+/3+) exhibited strong Fenton-like catalase-like activity. In another aspect, itself brand-new sonosensitizer high-performance SDT based on ultrasound-triggered electron (e–)/hole (h+) pair separation from the energy band promptness high efficiency. With efficient enrichment tumorous tissue revealed by magnetic resonance imaging, CPF could generate •OH CDT relying reactions. Moreover, catalase-mimicking react endogenous H2O2 molecular oxygen, O2 level may promote production 1O2 SDT. What's more, reactive oxygen species obtained combined SDT/CDT efficiently trigger immunogenic cell death synergistic antitumor immunity aid an checkpoint blockade sake suppressing primary distant well lung metastasis. Taken together, this paradigm delivers useful insights developing in-coming nanocomposites cobalt ferrite theranostics.

Language: Английский

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Piezotronic Effect-Augmented Cu_2–xO–BaTiO₃ Sonosensitizers for Multifunctional Cancer Dynamic Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9304 - 9316

Published: June 14, 2022

Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron-hole pairs. Herein, Cu2-xO-BaTiO3 piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, improving reactive oxygen species (ROS) generation therapeutic outcome. Under US irradiation, heterojunction with piezotronic effect exhibits high-performance singlet (1O2) hydroxyl radical (•OH) enhance SDT. Moreover, it possesses Fenton-like reaction activity convert endogenous H2O2 into •OH (CDT). The integration SDT CDT substantially boosts ROS cellular mitochondria damage, in vitro vivo results demonstrate high cytotoxicity tumor inhibition murine refractory breast cancer. This work realizes improvement using heterostructures effects.

Language: Английский

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Piezoelectric Au-decorated ZnO nanorods: Ultrasound-triggered generation of ROS for piezocatalytic cancer therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 135039 - 135039

Published: Feb. 4, 2022

Language: Английский

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Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 6, 2023

Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that hydrogel with enhance cell migration induce stem cells secrete TGF-β1, promotes chondrogenesis. vivo, rabbits osteochondral critical-size defects receiving ultrasound-activated show increased subchondral bone formation, improved hyaline-cartilage structure, good mechanical properties, close healthy native cartilage. This is not useful for healing also potentially applicable other tissue regeneration, offering significant impact on field regenerative engineering.

Language: Английский

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Noble metal-based nanomaterials as antibacterial agents

Journal of Alloys and Compounds, Journal Year: 2022, Volume and Issue: 904, P. 164091 - 164091

Published: Feb. 4, 2022

Language: Английский

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